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1.
T. Malati G. Rajani Kumari P. V. L. N. Murthy Ch. Ram Reddy B. Surya Prakash 《Indian journal of clinical biochemistry : IJCB》2006,21(1):34-40
Prostate Specific Antigen (PSA) has emerged as the most applicable and important tumor marker for carcinoma prostate. In the
present study PSA was determined in serum of healthy subjects, patients of benign prostate hypertrophy (BPH) and Carcinoma
Prostate (Ca−P) to evaluate its diagnostic efficiency in day to day management of prostate cancer patients and in differentiating
patients of early prostate cancer from those with BPH. Receiver operating characteristic curve (ROC) revealed 2 ng/ml and
10 ng/ml cut off serum PSA level for BPH and untreated carcinoma prostate patients (Ca−P). An extremely significant increase
(P<0.0001) was observed in mean PSA concentration in BPH patients and adenocarcinoma prostate patients when compared to healthy
males. Clinical relevance of PSA was highlighted by a case study of cancer patient prior to any therapy till death. 相似文献
2.
R. Dhananjayan T. Malati Y. Rupasree Vijay Kumar Kutala 《Indian journal of clinical biochemistry : IJCB》2015,30(3):263-270
The present work was aimed to study the association of one carbon genetic variants, hyperhomocysteinemia and oxidative stress markers, i.e., serum nitrite, plasma malondialdehyde (MDA) and glutathione (GSH) on intimal medial thickening (IMT) in patients with type 2 diabetes mellitus (T2D). A total number of 76 subjects from ACS Medical College and Hospital, Chennai, India were included in the study, i.e., Group I (n = 42) of T2D and Group II (n = 34) of age- and sex matched healthy controls. The glycated haemoglobin was measured by ion-exchange resin method; plasma homocysteine by Enzyme Linked Immunosorbant Assay method; serum nitrite (nitric oxide, NO), plasma MDA and GSH by spectrophotometric methods; the IMT by high frequency ultrasound. The polymorphisms of one carbon genetic variants were genotyped using polymerase chain reaction-restriction fragment length polymorphism and amplified fragment length polymorphism methods. Results indicate that methyltetrahydrofolate homocysteine methyl transferase (MTR) A2756G allele was found to be protective in T2D and the other variants were not significantly associated with T2D. Glutamate carboxypeptidase II (GCP II) C1561T (r = 0.34; p = 0.05) and methylene tetrahydrofolate reductase (MTHFR) C677T (r = 0.35; 0.04) showed positive correlation with plasma homocysteine in T2D cases. In this study, MTR A2756G allele was found to be protective in T2D; GCP II C1561T and MTHFR C677T showed positive association with plasma homocysteine in T2D cases. Among all the genetic variants, MTR A2756G was found influence IMT. RFC 1 G80A and TYMS 5′-UTR 2R3R showed synergistically interact with MTR A2756G in influencing increase in IMT. 相似文献
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T. Malati G. Rajani Kumari I. Dinakar 《Indian journal of clinical biochemistry : IJCB》1995,10(2):72-76
Humoral immune response against PPD derived A60 antigen was evaluated by quantification of serum A60 antibodies in thrity healthy adults not exposed to tuberculosis (Group 1), in twenty seven healthy adults exposed to tuberculosis patients i.e. staff working in wards of tuberculosis hospital for one to thirty years (group 2), in twenty five pulmonary tuberculosis patients admitted to the Institute for Chest Diseases, Hyderabad (Group 3) and in sixty neurotuberculosis patients admitted to Neurosurgery department of our institute (Group 4). Highly significant elevation of A60 antibodies was observed in pulmonary tuberculosis patients (p<0.01) compared to healthy adult groups. A significant elevation in serum was also observed in case of neurotuberculosis group compared to both healthy groups (p<0.01). A test on A60 antibodies in serum gavv a sensitivity of 100%, specificity of 96.6%, positive predictive value of 81% and negative predictive value of 100% for pulmonary tuberculosis, whereas a sensitivity of 58%, positive predictive value of 79% and negative predictive value of 75% were noted for neurotuberculosis patients. Results of A60 antibodies in ten cerebrospinal fluids (CSF) obtained from non tuberculosis patients and thirty two CSF from patients of neurotuberculosis did not show significant elevation of antibodies. However the ninetyfive percentile value of CSF A60 antibodies was higher in neurotuberculosis (7.4 U/ml) group compared to nontuberculous group (3.8 U/ml) and the test showed a good positive predictive value (83%), very low negative predictive value (25%) and low sensitivity (63%). Serum A60 antibody assay appears to be a good serological marker available today for pulmonary tuberculosis and a supportive marker for neurotuberculosis. 相似文献
6.
T. Malati G. Rajani Kumari B. Yadagiri 《Indian journal of clinical biochemistry : IJCB》2001,16(2):224-233
Ovarian cancer is the fifth leading cause of death in women. The incidence of this malignancy increases in women over the
age of 40. The overall five years survival is less than 30%, as most women present with advanced stage disease. Until recently,
detection of early stage ovarian cancer has been difficult since it is usually nonpalpable and asymptomatic. The definitive
diagnosis of an ovarian mass is a common problem in gynecologic patients with adnexal mass. The routine standard evaluation
for adnexal masses includes patient's history, physical examination, ultrasound and histopathological examination. These parameters
individually or in combination have little predictive value. The accuracy of diagnostic tools are of immense value and great
concern to practicsing Gynecologists and Oncologists. The clinical application of serum concentration of CA 125, AFP and hCG
is of great help not only as diagnostic aid but also in monitoring efficacy of any treatment modality like chemotherapy, radiotherapy
or surgical resection. Additionally, evaluation of tumor marker concentration helps in predicting early biochemical recurrence
and in prognostication in different types of ovarian malignancies. The ability to differentiate a malignant mass from a benign
pelvic mass pretherapeutically could be enhanced optimally by additional use of tumor markers such as cancer antigen CA-125,
alphafetoprotein and human chorionic gonadotrophin in pre-and postmenopausal women. 相似文献
7.
Tangirala Malati D. Murali Mohan Krishna V. R. Srinivasan V. Shantharam 《Indian journal of clinical biochemistry : IJCB》1992,7(2):138-142
Glycosylated Hemoglobin (GHb) was estimated using cation exchange resin binding method in 50 non diabetic healthy controls and 500 maturity onset diabetics. Percentage of glycosylated hemoglobin levels in controls was 7.27±0.456 (range 6.0–8.04) and 9.47±0.98 (range 8.2–13.63) in diabetic group. Glycosylated hemoglobin levels remain unaffected inspite of transient rise of serum glucose levels during an oral glucose tolerance test. Significantly elevated GHb A1. Furthermore significant elevation of GHb A1 was noticed in diabetics with all secondary complications suggesting poor glycemic control in these patients. The diabetics having retinopathy, nephropathy or diabetic foot had relatively higher GHb levels compared to patients having coronary artery disease or hypertension. 相似文献
8.
T. Malati 《Indian journal of clinical biochemistry : IJCB》2001,16(1):1-8
The neoplastic proliferation of single clones of plasma cells causes synthesis of very large amount of monoclonal immunoglobulins
consisting of only one type of heavy either the gamma, alpha, mu, delta or epsilon chain or only kappa or lambda light chains.
Each monoclonal immunolobulin differs idiotypically from each other. These monoclonal immunoglobulins are also called paraproteins
and are frequently associated with a broad heterogeneous group of plasma cell dyscrasias. Occasionally their presence is observed
in a few benign conditions and in old age. In the present review a detailed account of different types of monoclonal gammapathies
are described. 相似文献
9.
The serum PSA is universally accepted as the useful and clinically relevant tumor marker for monitoring therapy and identifying
early recurrence in patients of carcinoma prostate throughout the world. However, application of serum PSA is limited to screening
for early adenocarcinoma prostate among males above fifty years of age.
Serum PSA concentration varies from one population to another in different parts of the world. Many groups of workers have
selected 4 ng/ml of serum PSA as upper limit of normal range without giving due consideration for age specific increase in
serum PSA. There is no single report available on normal decade wise age specific reference intervals for serum PSA in Indian
males.
The present study is undertaken to establish age specific reference intervals in healthy Indian males from 20–89 years belonging
to subpopulation of Andhra Pradesh from South India. Our results revealed lowest concentration of 95 percentile serum PSA
in Indian males compared to other populations globally. Contrary to this, healthy Afro Americans were found to have highest
concentration of serum PSA compared to all other populations. 相似文献
10.
T. Malati G. Rajani Kumari B. Yadagiri V. Shanta Ram K. S. Ratnakar 《Indian journal of clinical biochemistry : IJCB》1996,11(1):77-80
A 67 years old male patient presented with skeletal metastasis and an unidentified primary neoplasm was referred to department of Biochemistry, NIMS for estimation of tumor markers. High values of CA-19-9, CEA and repeated biopsy reviews identified primary malignancy in gall bladder. 相似文献