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An in vivo head impact dosimeter, termed the ??intelligent mouthguard??, is under development at the Cleveland Clinic. The intelligent mouthguard facilitates correlation of acute and accumulative impact dosage with injury risk. As part of intelligent mouthguard dosimetry development for boxing and mixed martial arts participants, head and neck impact dosage was quantified in the laboratory for seven (7) punch types. Impact dosage data for punches were collected, which generated unique ??fingerprints?? for use with the intelligent mouthguard computational algorithm. Additional calculations were made on parameters based on each punch ??fingerprint?? and injury risk. Each of the punches had a unique ??fingerprint??. The hook imparted the most severe impact dosage, with the cross and oblique hook inducing the next most severe impact dosages, respectively. The impact dosage ??fingerprints?? determined here will be used to identify punch types during intelligent mouthguard human trials in 2012. Intelligent mouthguard dosimetry will be available soon for other contact sports (American Football, Ice Hockey, Lacrosse) to monitor head?Cneck impact dosage for correlation to acute or accumulative injury risk.  相似文献   
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Background: NHS Library Services are utilised by NHS staff and junior trainees to locate scientific papers that provide them with the evidence base required for modern medical practice. The cost of accessing articles can be considerable particularly for junior trainees. Objectives: This survey looks at variations in cost of journal article loans and investigates access to particular orthopaedic journals across the country. Methods: A national survey of UK Health Libraries was performed. Access to and costs of journals and interlibrary loan services were assessed. Availability of five wide‐reaching orthopaedic journals was investigated. Results: Seven hundred and ten libraries were identified. One hundred and ten libraries completed the questionnaire (16.7%). Of these, 96.2% reported free access to scientific journals for users. 99.1% of libraries used interlibrary loan services with 38.2% passing costs on to the user at an average of £2.99 per article. 72.7% of libraries supported orthopaedic services. Journal of Bone and Joint Surgery (British) had greatest onsite availability. Conclusions: The study demonstrates fluctuations in cost of access to interlibrary loan services and variation in access to important orthopaedic journals. It provides a reflection of current policy of charging for the acquisition of medical evidence by libraries in the UK.  相似文献   
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Coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a global health problem, India being the second most affected country. The kinetics of antibody response to SARS-CoV-2 in Indian population is not studied yet. To understand serological response in relation to age, gender, time period and severity of disease, Roche Elecsys anti-SARS-CoV-2 test was used which analysed both IgM and IgG. One hundred and three COVID-19 patients were enrolled. Seropositivity was seen in 64% of patients, with 33% at ≤ 7 days, 62% between 8 and 15 days and 81% at ≥ 16 days from the time of admission. Men (65%) showed higher antibody response than women (59%), whereas no difference was observed in seropositivity with respect to age of the patients. Dynamics of antibody responses revealed individual variations. Patients in ICU had higher antibody reactivity with 67% positivity as compared to 60% positivity in non-ICU patients. Kinetics of antibody response during COVID-19 disease varied in relation to gender, age, time period and severity and these factors might play an important role in treatment and control of COVID-19.  相似文献   
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With ever increasing information being available to the end users, search engines have become the most powerful tools for obtaining useful information scattered on the Web. However, it is very common that even most renowned search engines return result sets with not so useful pages to the user. Research on semantic search aims to improve traditional information search and retrieval methods where the basic relevance criteria rely primarily on the presence of query keywords within the returned pages. This work is an attempt to explore different relevancy ranking approaches based on semantics which are considered appropriate for the retrieval of relevant information. In this paper, various pilot projects and their corresponding outcomes have been investigated based on methodologies adopted and their most distinctive characteristics towards ranking. An overview of selected approaches and their comparison by means of the classification criteria has been presented. With the help of this comparison, some common concepts and outstanding features have been identified.  相似文献   
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Ovulation induction has been an important mode of treatment of infertility. Ovarian stimulation may result in a supraphysiologic response leading to an iatrogenic complication known as the ovarian hyperstimulation syndrome (OHSS). This syndrome is potentially a lethal condition, the pathophysiologic hallmark of which is the accumulation of massive extravascular exudate combined with profound intravascular volume depletion and hemoconcentration. We report a case of severe OHSS with very large ovaries in a 35 year old case of embryo transfer. The patient presented to the emergency department with abdominal pain, massive ascites, respiratory distress and amenorrhea. The patient was managed symptomatically with no complications. Although ovarian hyperstimulation is a rare entity, it is important that the physician recognizes this condition. Prompt diagnosis and successful management is likely to avoid serious and rapid development of complications.  相似文献   
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Ceruloplasmin levels were estimated in sera of, 40 patients with head and neck cancers. The levels were found to be significantly higher in patients as compared to the controls. The rise was nearly same in all the patients studied irrespective of the site, character or histopathology of lesion but was directly proportional to the stage of cancer. A reduction in serum ceruloplasmin was observed after radiotherapy.  相似文献   
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