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P-selectin, a cell adhesion molecule is elevated in many inflammatory conditions including preeclampsia which is characterized
by generalized endothelial dysfunction and vasoconstriction presumably due to free radicals or mediators released by defective
placentation. Vitamin E has been documented to protect cell membranes from oxidative damage and also decrease platelet aggregation.
The role of vitamin E in pre-eclampsia is contradictory and hence the study was undertaken. Soluble P-selectin was measured
by ELISA and Vitamin-E levels in plasma was estimated spectrofluorometrically. In our study the effect of supplementation
of 400 IU/day of Vitamin E (a-tocopheryl acetate) to patients of pre-eclampsia showed significant decreased levels of soluble
P-selectin by 2nd week as compared to patients given placebo (P = 0.005). In this short period of study no direct correlations were observed between Vitamin E or P-selectin levels with
blood pressure as well as with proteinuria. Future studies may focus on the effect of a-tocopheryl acetate or the phosphate
form of Vitamin-E, recently proposed to be the more active form on other inflammatory markers like IL-6, an important stimuli
of P-selectin release in pre-eclampsia. 相似文献
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The dropout rate among Spanish university students is very high compared to the European mean, creating a pressing need for the introduction of policies and programmes aimed at increasing rates of persistence. In this article, we study this problem by combining students’ perceived learning outcomes with their dropout intentions, and we propose a research model that considers subjective factors that might impact this decision. The model is estimated for two degree courses: Business Administration and Nursing. The estimation method uses structural equations based on the partial least squares algorithm. This allows the construction of indices for the variables of interest, enabling us to make comparisons between courses and over time. To reduce dropout intentions, efforts need to be focused on obtaining better cognitive outcomes, as well as on achieving a higher level of student satisfaction with their university experience. 相似文献
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Adam Bartsch Edward Benzel Vincent Miele Douglas Morr Vikas Prakash 《Sports Engineering》2012,15(2):93-109
An in vivo head impact dosimeter, termed the ??intelligent mouthguard??, is under development at the Cleveland Clinic. The intelligent mouthguard facilitates correlation of acute and accumulative impact dosage with injury risk. As part of intelligent mouthguard dosimetry development for boxing and mixed martial arts participants, head and neck impact dosage was quantified in the laboratory for seven (7) punch types. Impact dosage data for punches were collected, which generated unique ??fingerprints?? for use with the intelligent mouthguard computational algorithm. Additional calculations were made on parameters based on each punch ??fingerprint?? and injury risk. Each of the punches had a unique ??fingerprint??. The hook imparted the most severe impact dosage, with the cross and oblique hook inducing the next most severe impact dosages, respectively. The impact dosage ??fingerprints?? determined here will be used to identify punch types during intelligent mouthguard human trials in 2012. Intelligent mouthguard dosimetry will be available soon for other contact sports (American Football, Ice Hockey, Lacrosse) to monitor head?Cneck impact dosage for correlation to acute or accumulative injury risk. 相似文献
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