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Zoltán L?csei István Szabolcs Károly Rácz Gábor L. Kovács Dóra Horváth Erzsébet Toldy 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2012,22(3):365-370
High concentration of thyroglobulin antibodies (TgAb) is a major limiting factor of thyroglobulin measurements in patients with differentiated thyroid cancer. We investigated whether thyroglobulin antibody added to serum samples could interfere with the thyroglobulin assay. Thyroglobulin levels in serum samples with different concentrations of thyroglobulin were measured by electrochemiluminescence immunoassay before and after the addition of increasing concentrations of thyroglobulin antibody using the secondary calibrator solution of the thyroglobulin assay kit containing sheep thyroglobulin antibody to reach thyroglobulin antibody levels within or near to the reference range. Thyroglobulin and thyroglobulin antibody concentrations were also measured in 134 serum samples from 27 patients after thyroid ablation. There was a strong negative association (slope = −1.179) between thyroglobulin antibody and thyroglobulin concentrations in samples with added thyroglobulin antibody (beta = −0.86; P < 0.001). Changes in thyroglobulin concentrations were described mathematically as loss of thyroglobulin% = −0.2408 × Ln(thyroglobulin antibody IU/ml) + 0.1944. Thyroglobulin concentrations were significantly lower than those calculated from experiments with added thyroglobulin antibody in 26/134 samples from patients after thyroid ablation. We conclude that if the same TgAb interference exists in the presence of naturally occurring human TgAb, our observation may prove to be useful during follow-up of patients with differentiated thyroid cancer. However, further studies are needed to explore the clinical relevance of thyroglobulin antibody levels within or near to the reference range in monitoring these patients. 相似文献
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As an indicator of nations' prosperity and economic competitiveness, research impacts the mounting roles and requirements placed upon academic researchers. Internationally, researchers are expected to effectively operate in the fast-changing and demanding research environment. Such effectiveness corresponds mainly to their ability to establish international and interdisciplinary collaborations, secure internal and external grants, and most importantly deliver tangible research outputs. As such, this desired research excellence impacts researchers' academic appointments, recognitions and promotions. Driven by research productivity and pursuit of academic excellence, researchers' individual autonomy may become restricted. This work is based on (a) an international study exploring research productivity within higher education institutions across 15 countries and (b) a relevant international literature review. The voices of 32 participants portray competencies required from and requirements placed upon academic researchers at their respective universities. Findings show that the role of academic researchers is changing and the requirements pose challenges to researchers' autonomy. The research productivity quest along with opportunity-driven decisions may not only restrict researchers' autonomy but also compromise their academic integrity. 相似文献
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Abstract The dissemination of ideas and use of education technology needed a breakthrough, and this paper looks at how this is being achieved. 相似文献
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Inmaculada López María Luz Puertas Carmelo Rodríguez Manuel Gámez Zoltán Varga 《Journal of The Franklin Institute》2019,356(4):2240-2257
Monitoring problem in population ecology can be formalized as observer design for the population system in question: Supposing that we observe only certain species considered indicators, we want to recover or estimate the whole state process of the population system, where the state vector is usually composed from the biomasses of the single populations. In the present paper, for stably coexisting population systems, a new approach to the design of the corresponding observer system is proposed which, from the knowledge of the observed indicator(s), estimates the state process with exponential convergence. In the usual observer design, an auxiliary matrix, the so-called gain matrix must be found that guarantees the mentioned exponential convergence. The novelty is in that due to the required sign-stability (or qualitative stability) of the interaction pattern, the designed observer system (i.e. the gain matrix) is robust against quantitative changes in the inter- and intra-specific interactions. (Here the interaction pattern is described by a matrix having the signs as entries, indicating the quality of the interactions within and between the considered species.) In other words, under sign-stability conditions, in the observer design the same gain matrix can be used even if, due to environmental changes, the intensities of certain interactions suffer a quantitative change in the meanwhile. The requirement of sign-stability of the interaction pattern can be considered rather natural, since in a stably coexisting population system, it means for example that a predator–prey relation does not change into a prey–predator interaction, and interactions neither appear nor disappear within the system. Our approach to robust observer design is illustrated on model population systems, such as trophic chains of type resource-producer-primary consumer-secondary consumer and Lotka–Volterra system with vertical structure. For the latter system a Lyapunov function is also constructed that guarantees the global asymptotic stability of the positive equilibrium of the considered model. 相似文献
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where she directs the Department of Didactics. Main research interests: the teaching and learning process; curriculum theory; educational evaluation. 相似文献
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