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A Methylome‐Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder 下载免费PDF全文
Edward D. Barker Esther Walton Charlotte A.M. Cecil Richard Rowe Sara R. Jaffee Barbara Maughan Thomas G. O'Connor Argyris Stringaris Alan J. Meehan Wendy McArdle Caroline L. Relton Tom R. Gaunt 《Child development》2018,89(5):1839-1855
In 671 mother–child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7–13) of oppositional defiant disorder (ODD), and the ODD subdimensions of irritable and headstrong; (b) common biological pathways, indexed by DNA methylation, between ODD trajectories and attention deficit hyperactivity disorder (ADHD); (c) genetic influence on DNA methylation; and (d) prenatal risk exposure associations. Methylome‐wide significant associations were identified for the ODD and headstrong, but not for irritable. Overlap analysis indicated biological correlates between ODD, headstrong, and ADHD. DNA methylation in ODD and headstrong was (to a degree) genetically influenced. DNA methylation associated with prenatal risk exposures of maternal anxiety (headstrong) and cigarette smoking (ODD and headstrong). 相似文献
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Previous studies have distinguished cognitive, occupational status and network mechanisms in the relation between education and ethnocentrism. Hypotheses on these mediating mechanisms are derived from socialization theory, realistic group threat and contact theory. In the current study we use structural equation modeling to investigate the explanatory power of these three mechanisms simultaneously. The analysis is based on a representative population survey from the Netherlands (NELLS 2009, n = 1910). The results show that more than half of the initial association between education and ethnocentrism can be attributed to cognitive ability and occupational status mechanisms. The remaining part of the overall association, however, still has to be modeled as a direct relationship between education and ethnocentrism. This direct association can be attributed either to social desirability or to a direct liberalizing effect of education on social and political attitudes. Our analysis tentatively suggests that the rise of average education levels in Western societies might lead to less ethnocentric attitudes via the cognitive sophistication mechanism. 相似文献
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Bias in content validity on the Boehm Test of Basic Concepts for White and Mexican-American children
Wayne C. Piersel Barbara Sterrett Plake Cecil R. Reynolds Richard Harding 《Contemporary educational psychology》1982,7(2):181-189
Item bias on Forms A and B of the Boehm Test of Basic Concepts was examined for a sample of White and Mexican-American kindergarten children. The method employed to detect biased items, as defined by an items-by-group interaction, was a two-way analysis of variance with followup being conducted with a Bonferroni-type procedure. Bias-in-item difficulty occurred for both groups, which does not conform to the current popular press view that bias is against ethnic minorities and not against the White majority. The finding that on some items the Mexican-American group out-performed the White group indicates the need to examine carefully the question of bias and to reconsider popular conceptualizations of the many issues of bias in educational and psychological testing. 相似文献
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Cecil Meeusen 《The Journal of environmental education》2013,44(2):77-90
This article reports on the intergenerational transmission of environmental concern and the explanatory power of communication patterns within the family. Using representative data from the Parent-Child Socialization Study in Belgium (PCSS, 2012), this article focuses on the relative influence of the mother and the father, and gender-specific patterns in the transmission of environmental attitudes. The results clearly confirm the transmission hypothesis: both the mother and the father have a significant influence on the environmental concern of their offspring. No gender-specific transmission mechanisms were found. In families that communicate regularly about the environment, transmission was more effective. Nevertheless, the transmission effects were only moderate, indicating that environmental concern may not be a core attitude within Belgian families. 相似文献
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