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1.
Wojciech Szczęsny Magdalena Kuligowska-Prusińska Stanisław Dąbrowiecki Jakub Szmytkowski Adrian Reśliński Maciej Słupski 《Journal of Zhejiang University. Science. B》2018,19(1):65-70
Purpose
Metalloproteinases are a key component of the pathogenesis of abdominal hernias. Obesity is considered a risk factor in herniogenesis and hernia recurrence. The aim of this study was to evaluate the serum concentrations of metalloproteinase-2 (MMP-2), MMP-9, MMP-13, and adiponectin in morbidly obese and nonoverweight controls.Materials and methods
The participants were recruited from among patients undergoing bariatric and non-bariatric surgery and divided into two groups: I (body mass index (BMI)≥35 kg/m2, n=40) and II (BMI<25 kg/m2, n=30). Serum concentrations of MMP-2, MMP-9, MMP-13, and adiponectin were measured using enzyme-linked immunosorbent assay (ELISA).Results
A statistically significant difference between groups was observed for MMP-2 concentration. The median MMP-9 concentration was higher in the obese group, but the difference was not statistically significant. Median MMP-13 concentrations did not differ between groups. Serum adiponectin concentration was insignificantly higher in the non-obese group.Conclusions
The elevated serum MMP-2 and MMP-9 concentrations in obese individuals may be related to the higher incidence of incisional hernias in this population.2.
Danuta Ro?? Przemys?aw Adamczyk Joanna Boinska Robert Szafkowski Irena Ponikowska Katarzyna Stankowska Barbara Góralczyk Barbara Ruszkowska-Ciastek 《Journal of Zhejiang University. Science. B》2015,16(5):404-411
Objective
The aim of this study was to evaluate the concentrations of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and the degree of homeostasis model assessment-insulin resistance (HOMA-IR) in patients with morbid obesity exposed to a three-week low-calorie diet and balneotherapy.Methods
The study included 33 patients (25 females and 8 males; mean age 46 years) with body mass index (BMI) values of >40 kg/m2. Evaluations of CRP, IL-6, TNF-α, lipid profile, HOMA-IR, and fasting glucose were carried out before (baseline data) and three weeks after the treatment. The control group consisted of 20 healthy volunteers (15 females and 5 males) with a mean age of 39 years and BMI values of ≤24.9 kg/m2.Results
In the blood of patients with morbid obesity we found significantly elevated levels of CRP, TNF-α, triglycerides, HOMA-IR and fasting glucose, but a decreased level of high density lipoprotein (HDL)-cholesterol, compared with the healthy individuals. The treatment resulted in about a 9.4% reduction in body weight from 122.5 to 111.0 kg and a significant decrease in the concentration of CRP, but no change in TNF-α or IL-6. HOMA-IR was significantly reduced.Conclusion
The decrease in CRP level without changes in TNF-α or IL-6 concentrations after the low-calorie diet and balneological treatment, suggests that an essential amount of adipose tissue must be removed before proper adipocyte function is restored. The decrease in HOMA-IR indicates an improvement in insulin sensitivity, which is beneficial in obese patients.3.
A seven channel polystyrene (PS) microchip has been constructed using a micromilling machine and a high-temperature assembling. Protein A (PA) has been immobilized by a passive sorption on the microchannel walls. Two bioaffinity assays with human immunoglobulin G (hIgG) as a ligand have been carried out. (i) PA as the receptor and fluorescently labeled hIgG (FITC-hIgG) as the ligand, (ii) PA as the receptor with hIgG as the quantified ligand and fluorescently labeled goat anti-human IgG (FITC-gIgG) as the secondary ligand. One incubation step of the assays took only 5 min instead of hours typical for enzyme-linked immunosorbent assay applications. Calibration curves of the dependence of a fluorescence signal on the hIgG concentration in a sample have been obtained in one step due to a parallel arrangement of microchannels. A mathematical model of the PA-FITC-hIgG complex formation in the chip has been developed. The values of the kinetic constant of the PA-FITC-hIgG binding (kon=5.5 m3 mol−1 s−1) and the equilibrium dissociation constant of the formed complex (Kd≤3×10−6 mol m−3) have been obtained by fitting to experimental data. The proposed microchip enables fast evaluation of kinetic and equilibrium constants of ligand-receptor bioaffinity pairs and the ligand quantification. As the use of microfluidic chips for immunoassays is often limited by price, we used procedures and chemicals that allow for an inexpensive construction and operation of the microdevice, e.g., temperature assembling as a fabrication technique, detection via an ordinary digital camera, nonspecific polystyrene as a substrate, passive sorption of biomolecules as an immobilization technique, etc. 相似文献
4.
The question is whether or not we or any student are allowed to define a measure of variability in some other way that is not written in textbooks and officially approved. We compare the sum of squares of all deviations against the usual sum of squares of deviations from the mean. 相似文献
5.
On knowledge-poor methods for person name matching and lemmatization for highly inflectional languages 总被引：1，自引：1，他引：0
Web person search is one of the most common activities of Internet users. Recently, a vast amount of work on applying various
NLP techniques for person name disambiguation in large web document collections has been reported, where the main focus was
on English and few other major languages. This article reports on knowledge-poor methods for tackling person name matching
and lemmatization in Polish, a highly inflectional language with complex person name declension paradigm. These methods apply
mainly well-established string distance metrics, some new variants thereof, automatically acquired simple suffix-based lemmatization
patterns and some combinations of the aforementioned techniques. Furthermore, we also carried out some initial experiments
on deploying techniques that utilize the context, in which person names appear. Results of numerous experiments are presented.
The evaluation carried out on a data set extracted from a corpus of on-line news articles revealed that achieving lemmatization
accuracy figures greater than 90% seems to be difficult, whereas combining string distance metrics with suffix-based patterns
results in 97.6–99% accuracy for the name matching task. Interestingly, no significant additional gain could be achieved through
integrating some basic techniques, which try to exploit the local context the names appear in. Although our explorations were
focused on Polish, we believe that the work presented in this article constitutes practical guidelines for tackling the same
problem for other highly inflectional languages with similar phenomena.
相似文献
| Marcin SydowEmail: |
6.
Sasho J. Mackenzie Scott M. Foley Andrew P. Adamczyk 《Journal of sports sciences》2013,31(12):1243-1251
Abstract The purpose was to evaluate the traditional method, of visually focusing on the ball, in comparison to focusing on the hole, during the putting stroke. The study design consisted of a pretest, a 4-week practice period, and a posttest. Participants (n = 31, handicap: 18.7 ± 10.4) practised using only one of the two gaze techniques. Testing consisted of having all participants putt using both gaze techniques from both a 1.22 m and a 4 m distance. Five putts were executed for each gaze technique/putt length combination for a total of 20 putts in each testing session per participant. The kinematics of every putting stroke executed during testing (1240 strokes) were captured using a TOMI® system. There was a significant improvement in putting success for both groups following practice (P = 0.001). Practising while visually focusing on the hole, resulted in a statistically significant reduction in putter speed variability in comparison to practising while visually focusing on the ball (P = 0.017). Visually focusing on the hole did not meaningfully (nor statistically) affect the quality of impact as assessed by the variability in face angle, stroke path, and impact spot at the precise moment the putter head contacted the ball. 相似文献
7.
This article shows how the probability of enrolment in tertiary schools has evolved for different social groups in Poland during the period of the educational boom. It also analyses how the socio-economic status influences the choices between full-time and part-time studies (the latter being of relatively low quality), and the probability of admission to subsidised, free programmes versus programmes with tuition fees. Between 1994 and 2008, Poland improved the participation of students with a low socio-economic status in university education. However, if we look at the change in the ratios of enrolment probabilities for different layers of the social strata, we find that the improvement refers to those with a low family educational background who live in small cities, but not to those from low income families. Further investigation shows that the policy makers should focus not only on ensuring equal access to tertiary education for all social strata, but on allowing the unprivileged groups access to education of acceptable quality. 相似文献
8.
The purpose was to evaluate the traditional method, of visually focusing on the ball, in comparison to focusing on the hole, during the putting stroke. The study design consisted of a pretest, a 4-week practice period, and a posttest. Participants (n = 31, handicap: 18.7 ± 10.4) practised using only one of the two gaze techniques. Testing consisted of having all participants putt using both gaze techniques from both a 1.22 m and a 4 m distance. Five putts were executed for each gaze technique/putt length combination for a total of 20 putts in each testing session per participant. The kinematics of every putting stroke executed during testing (1240 strokes) were captured using a TOMI? system. There was a significant improvement in putting success for both groups following practice (P = 0.001). Practising while visually focusing on the hole, resulted in a statistically significant reduction in putter speed variability in comparison to practising while visually focusing on the ball (P = 0.017). Visually focusing on the hole did not meaningfully (nor statistically) affect the quality of impact as assessed by the variability in face angle, stroke path, and impact spot at the precise moment the putter head contacted the ball. 相似文献
9.
Science & Education - In this paper, we explored the scientific literacy of a general sample of the Slovak adult population and examined factors that might help or inhibit scientific reasoning,... 相似文献
10.
Jakub Hladik 《Multicultural Perspectives》2016,18(1):42-47
In this article, I focus on assessing multicultural competence of helping-profession students. The Multicultural Competence Scale of Helping-Profession Students was used for data collection. The aim of the research was to find out the level of students' multicultural competence due to the current lack of this information in Central Europe. Generally, students assess their multicultural competence on the higher level. There is a significant relationship between the students' study degree and the level of their multicultural competence. Multicultural activity was shown as an important predictor of multicultural knowledge. Also, multicultural knowledge was identified as a significant predictor of multicultural communication skills. 相似文献