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This paper addresses the flow control design of a connection-oriented communication network from the robust control theory perspective. Network is modelled as a nth order discrete system whose first order model is obtained using the two-time scale property associated with the process. The proposed scheme is characterised by an equivalent control based discrete sliding mode design for the first order model which is applied to nth order systems through aggregation. Besides its design simplicity, the proposed method exhibits finite time convergence property for the states while applied to the full order system emulating the characteristics of terminal sliding mode in a certain way. Simulation results via Matlab and ns-2 validate the efficacy of the proposed algorithm as an effective flow controller for connection-oriented networks.  相似文献   
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Pretreatment of an ethanolic extract of leaf ofPiper betle linn at a dose of 200mg/kg body weight, orally administered to rats for ten consecutive days, was found to possess a significant protective action against gastric lesions induced by indomethacin. The extract pretreatment resulted in significant increase in superoxide dismutase (SOD) and catalase (CAT) activity, increase in mucus, hexosamine and total thiol group content, but marked reduction in oxidatively damaged protein and peroxidised lipid levels as compared to untreated ulcerated control. The extract was also found to possess both superoxide and hydroxyl free radical scavenging action. The present observations establish the efficacy of the extract in prevention of experimentally induced peptic ulcer by indomethacin and antioxidant property appears to be predominantly responsible for such cytoprotective activity in the experimental model.  相似文献   
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Hyper-ferrous state is the result of multiple transfusions, whereby the iron excess in such conditions may be toxic to the organism. Patients suffering from thalassemia receive multiple transfusions. In the eastern part of India, both β0-thalassemia and heterozygous Eβ-thalassemia occur. This paper expresses the hyper-ferrous state, leading to iron overload in these two conditions and also reports the increased generation of free radicals, consequent to the iron overload.  相似文献   
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The Mach number, angle of attack and altitude of operation for an interceptor vary widely during the course of its trajectory. As a result, the interceptor Center of Pressure (CP) locations move significantly around a given Center of Gravity (CG) location at these operating conditions. This results in an inevitable variation in aerodynamic static stability leading to stable and unstable operating regions. In order to ensure good speed of response during the interceptor homing phase, lesser static stability is desirable. Hence the requirement to handle aerodynamic instability at some other operating conditions in the interceptor envelope become inevitable. Since flexibility has a strong bearing on autopilot design, it becomes necessary to control unstable operating points in the presence of flexibility modes. Despite the static stability variation, aerodynamic design can control the level of maximum instability of the configuration. Hence the maximum static instability the autopilot can handle has to be specified for aerodynamic configuration design. This paper brings out the limitations of autopilot design in controlling an unstable interceptor with low bending mode frequencies in terms of maximum instability the autopilot design can handle, which serves as an important input for aerodynamic design.  相似文献   
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In this paper, sliding mode control for discrete time systems with stochastic noise in their input channel has been discussed. The idea of process control using control charts has influenced this new approach towards dealing with systems with stochastic noise. The new approach approximates the stochastic noise as a bounded uncertainty, similar to having bounds in the control charts for stochastic process control data. For discrete time systems, this results in a bounded stability in probability of the quasi sliding mode, which is referred to as the N-sigma bounded stability. The probability associated with the stability notions is not fixed and the control engineer may desire lower or higher degrees of stability in terms of this probability. Thus one has design flexibility while implementing the theory in practice, where one might have to adjust the desired degree of stability due to hardware limitations.  相似文献   
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Cancer cells generally exhibit increased glycolysis for ATP generation (the Warburg effect). Compounds that inhibit glycolysis have potential applications in cancer treatment. dl-glyceraldehyde (DLG) and 2-Deoxyglucose (2-DG) have been proven effective in the inhibition of glucose metabolism. Ehrlich ascites carcinoma (EAC) cells were injected intraperitoneally (i.p) in 10–12 weeks old Swiss albino mice, weighing between 20 and 30 g. The anticancer activity of DLG and 2-DG were determined by tumor volume, tumor weight, viable and nonviable tumor cell count, average survival time, percentage increase in life span and tumor inhibition ratio. The blood samples were obtained for biochemical analysis after 9 days of treatment to study the effect on liver, kidney and haematological parameters. Histopathological examination of liver and kidney was also performed. One-way ANOVA test and Dunnett’s test were used for comparisons of parameters in study groups. Both DLG and 2-DG individually decreased the tumor weight, tumor volume, viable tumor cell count and significantly increased the life span of treated mice, however the combination was found to be better. The biochemical parameters of liver and kidney functions and haematological parameters were restored close to control group as compared with the EAC bearing mice. Histopathological examination of liver and kidney in EAC control group showed large areas of necrosis, congestion and mononuclear cell infiltration but such changes were not observed in liver and kidney sections observed after i.p injection of DLG and 2-DG for 9 days. Improvement was much better in the group where combination of these two drugs were used.  相似文献   
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Fasting samples of 1396 apparently healthy, middle class Bengali population of Kolkata, West Bengal were tested for total cholesterol, triglycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol and very low density lipoprotein cholesterol, over a period of three years. The values obtained were (in mg/dl) 190±33, 132±42, 53±10, 116±30 and 21±7 respectively. When these subjects were grouped according to the age and sex, no appreciable difference were observed between most of the groups. Triglyceride was found to be low and HDL cholesterol was high in women below 30 years when compared with men of similar age. Beyond 60 years, cholesterol level as well as low density lipoprotein cholesterol was found to be gradually increased in case of women. Besides these changes, other minor differences were not statistically significant. It is suggested that the lipid values of the present study should be taken as a base parameters and the clinical evaluation be made on the basis of these finding.  相似文献   
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Ocimum sanctum Linn. (also known as Tulsi) is a sacred Indian plant, the beneficial role of which, in obesity and diabetes is described traditionally. This is a randomized, parallel group, open label pilot study to investigate the effect of O. sanctum on metabolic and biochemical parameters in thirty overweight/obese subjects, divided into two groups A and B. Group A (n = 16) received one 250 mg capsule of Tulsi (O. sanctum) extract twice daily in empty stomach for 8 weeks and group B (n = 14) received no intervention. Statistically significant improvements in the values of serum triglycerides (p = 0.019); low density lipoprotein (p = 0.001); high density lipoprotein (p = 0.001); very low density lipoprotein (p = 0.019); Body Mass Index, BMI (p = 0.005); plasma insulin (p = 0.021) and insulin resistance (p = 0.049) were observed after 8 weeks in the O. sanctum intervention group. The improvement in HDL-C in the intervention group when compared to the control group was also statistically significant (p = 0.037). There was no significant alteration of the liver enzymes SGOT and SGPT in both the intervention (p = 0.141; p = 0.074) and control arms (p = 0.102; p = 0.055) respectively. These observations clearly indicate the beneficial effects of O. sanctum on various biochemical parameters in young overweight/obese subjects.  相似文献   
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