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ABSTRACT

We performed a randomized, controlled trial to analyse the effects of resistance training (RT) on cognitive and physical function among older adults. Fifty participants (mean age 67 years, ~60% woman) were randomly assigned to an RT program or a control group. Participants allocated to RT performed three sets of 10-15RM in nine exercises, three times per week, for 12-weeks. Control group did not perform any exercise. Variables included cognitive (global and executive function) and physical function (gait, mobility and strength) outcomes. At completion of the intervention, RT was shown to have significantly mitigated the drop in selective attention and conflict resolution performance (Stroop test: -494.6; 95%CI: -883.1; ?106.1) and promoted a significant improvement in working memory (digit span forward: -0.6; 95%CI: ?1.0; ?0.1 and forward minus backward: -0.9; 95% CI: ?1.6; ?0.2) and verbal fluency (animal naming: +1.4, 95%CI 0.3, 2.5). No significant between-group differences were observed for other cognitive outcomes. Regarding physical function, at completion of the intervention, the RT group demonstrated improved fast-pace gait performance (?0.3; 95% CI: ?0.6; ?0.0) and 1-RM (+21.4 kg; 95%CI: 16.6; 26.2). No significant between-group differences were observed for other mobility-related outcomes. In conclusion, RT improves cognitive and physical function of older adults.  相似文献   
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Many self-propelled microorganisms are attracted to surfaces. This makes their dynamics in restricted geometries very different from that observed in the bulk. Swimming along walls is beneficial for directing and sorting cells, but may be detrimental if homogeneous populations are desired, such as in counting microchambers. In this work, we characterize the motion of human sperm cells ∼60 μm long, strongly confined to ∼25 μm shallow chambers. We investigate the nature of the cell trajectories between the confining surfaces and their accumulation near the borders. Observed cell trajectories are composed of a succession of quasi-circular and quasi-linear segments. This suggests that the cells follow a path of intermittent trappings near the top and bottom surfaces separated by stretches of quasi-free motion in between the two surfaces, as confirmed by depth resolved confocal microscopy studies. We show that the introduction of artificial petal-shaped corrugation in the lateral boundaries removes the tendency of cells to accumulate near the borders, an effect which we hypothesize may be valuable for microfluidic applications in biomedicine.  相似文献   
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It is acknowledged that knowledge and knowledge bases are an important part of coach and athlete learning and that the coach – athlete relationship is crucial to knowledge created, shared and used. This said knowledge about nutrition as constructed by elite gymnasts would seem particularly important in a culture long associated with weight control practices and disordered eating. This paper provides an insight into the ways that 10 Brazilian Olympic gymnasts construct ideas pertaining to nutritional knowledge across generational periods (between 1980 and 2004) where significant organisational change in Women’s Artistic Gymnastics in Brazil occurred and included the introduction of dieticians. Drawing upon different knowledge types and paying attention to the coaching context, the life histories of 10 Olympic gymnasts were used to open a window on knowledge construction pertaining to nutrition by three generations of gymnasts. The findings draw attention to two main illustrative themes. Firstly, coaches’ personal knowledge, whilst perceived as incomplete by gymnasts, reinforced a narrative of weight loss for gymnasts regardless of generation. Secondly, the younger generations of gymnasts perceived that the introduction of dieticians into structured provision enabled them to use better structured knowledge, and with it a sense of increased autonomy and corporeal learning via the construction of tacit embodied knowledge leading to healthier practices. Reflections are given to the role of the coach, dieticians and pedagogical actions, and the continued reshaping of knowledge in elite gymnastics.  相似文献   
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