基于二模复杂网络的隐性知识发现方法研究——以潜在药物靶点挖掘为例     

李东巧  陈芳  韩涛  杨艳萍  王学昭  王燕鹏  Cynthia Liu  Yingzhu Li 《图书情报工作》2020,64(21):120-129

[目的/意义] 通过构建二模复杂网络模型，揭示隐藏在海量文献中的隐性知识。[方法/过程] 通过NetworkX复杂网络工具包，依据任意两个节点的共现关系构建二模复杂网络模型；对网络模型中节点的共现关系进行加权，计算网络的拓扑信息并进行AP聚类，提取节点间的直接关系；采用AUC方法对AA、JC、加权改进的wAA和wJC等4种链路预测算法进行评价，遴选出最合适的预测算法，并对复杂网络的隐性关系进行预测分析。[结果/结论] 以潜在药物靶点挖掘为例进行的实证研究结果表明，wAA链路预测算法为最优的链路预测算法；二模复杂网络模型、指标和方法体系在美国化学文摘社数据库中的药物靶点挖掘中具有一定的有效性。下一步计划在其他数据库中或其他研究领域中进行尝试，以进一步验证该模型的通用性和有效性。  相似文献   

Effects of Manipulative Instruction on Solving Area and Perimeter Problems by Students with Learning Disabilities     

Mike Cass  Dennis Cates  Michelle Smith  Cynthia Jackson 《Learning disabilities research & practice》2003,18(2):112-120

Abstract. A multiple baseline design was employed to test the effect of manipulative instruction on the perimeter and area problem‐solving performance of middle and high school students who had been diagnosed with LD in the area of mathematics. Modeling, prompting/guided practice, and independent practice in conjunction with manipulative training were employed to teach both perimeter and area problem‐solving skills. Analysis of data revealed that the students rapidly acquired the problem‐solving‐skills, maintained these skills over a two‐month period, and transferred these skills to a paper and pencil problem‐solving format. This research extends previous findings by revealing that use of concrete manipulatives promotes the long‐term maintenance of skills.  相似文献   

Good High Schools for Students with Disabilities     

Catherine Cobb Morocco  Cynthia Mata Aguilar  Karen Clay  Nancy Brigham  Naomi Zigmond 《Learning disabilities research & practice》2006,21(3):135-145

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The Future of English     

Chris Davies 《English in Education》1991,25(3):28-31

The unity of "unitary" English, subsuming "language" and "literature", has always been a central tenet of NATE thinking and a basic assumption of most progressive practice, and is now enshrined in the National Curriculum¹. In this article, however, Chris Davies makes the scandalous proposal that the time has come when "language" and "literature", radically transformed, would be better separated.  相似文献   

Non-finite loss and challenges to communication between parents and professionals     

Elizabeth Bruce  & Cynthia Schultz 《British Journal of Special Education》2002,29(1):9-13

Elizabeth Bruce PhD, a psychologist in private practice, and Cynthia Schultz PhD, honorary associate at LaTrobe University, both live and work in Australia. Their work on supporting parents who have children with special needs, however, has been published around the world. In this article Bruce and Schultz explore the notion of 'non-finite loss', defined as the ongoing sense of grief experienced by parents caring for children with severe disabilities. The authors discuss the issues that professionals need to consider when working with parents in these circumstances. The article closes with a set of recommendations for promoting more effective partnerships between parents and professionals.  相似文献   

年代统计学:超越人口统计学的市场营销战略     

Chris Penttila  王丽娜 《深圳特区科技》2005,(8):72-73

长期以来，企业通常利用年龄、收入、性别与受教育程度等基本的人口统计信息来进行市场定位并制定营销战略。  相似文献   

Do physical activity beliefs differ by age and gender?   总被引：1，自引：0，他引：1  

Rhodes RE  Blanchard CM  Blacklock RE 《运动与训练心理学杂志》2008,30(3):412-423

Age and gender are consistently related to physical activity (PA), yet theoretical explanation for these associations is scant. The present study compared the mean values and correlations of a population sample, divided by gender and age group, with respect to theory of planned behavior beliefs (behavioral, normative, and control) and PA. Participants were a sample (N=6,739) of adults (M age=49.65, SD=16.04) who completed measures of social and health demographics, theory of planned behavior beliefs, and self-reported PA. Mean analyses identified greater perceived control over PA for seniors than for young and middle-aged adults (N>.025). Belief-behavior correlations, however, were not different across age and gender in 24 of 26 tests (q<.19). Thus, PA beliefs are invariant across age and gender with the exception of mean levels of perceived control, which are lower among younger adults than older adults. Factors such as early parenthood and career demands were considered the likely reasons for differences. Overall, the evidence suggests that adapting theoretical models for specific age groups or based on gender may not be necessary.  相似文献   

Biodiversity for Beginners     

Chris Du Feu 《Teaching Statistics》2006,28(3):66-70

Biodiversity is a difficult concept. It can be introduced to young children successfully, laying the foundations for further study in later years. This article describes one practical activity for 5‐ and 6‐year‐old children.  相似文献   

Ubiquitous Computing in the Library:Indiana State University Library s Experience     

Ralph B.Gabbard Judith Tribble Paul Asay Chris Hayes 《现代图书情报技术》2002,(Z1)

1 Introduction New technologies and other developments haye changedthe information seeking behaviors of the academic communityand the general public.Nowhere is this more evident than inthe exponential growth of the World Wide Web and cellularphone usage.Responding to these user needs and newtechnologies,libraries are moving from being InformationWarehouses to becoming Information Portals.Full-text  相似文献   

So many filters, so little time: the development of a search filter appraisal checklist          下载免费PDF全文

Julie Glanville  Sue Bayliss  Andrew Booth  Yenal Dundar  Hasina Fernandes  Nigel David Fleeman  Louise Foster  Cynthia Fraser  Anne Fry-Smith  Su Golder  Carol Lefebvre  Caroline Miller  Suzy Paisley  Liz Payne  Alison Price    Karen Welch 《Medical Library and Historical Journal》2008,96(4):356-361

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