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Emad F. Eskander Ahmed A. Abd-Rabou Shaymaa M. M. Yahya Ashraf El Sherbini Mervat S. Mohamed Olfat G. Shaker 《Indian journal of clinical biochemistry : IJCB》2014,29(1):3-7
Viral infection with hepatitis C virus (HCV) has a high propensity in becoming chronic and it is the major cause of hepatocellular carcinoma (HCC) worldwide. This review was basically established to illustrate the putative role of the P53 gene Arg72Pro polymorphism on various cancer models and viral infections, focusing on HCV and HCC incidences. Authors studied the 72 G/C single base substitution of P53 gene at codon 72 using various polymorphic techniques. Intriguingly, authors investigated that the P53 codon 72 plays a crucial role as risk factor in several cancer models. Others found that there is no association between codon 72 genotypes and HCV disease severity or liver cancer. Moreover, the lack of a significant relationship between this polymorphism and risk of HCC shows that it does not predispose towards hepatocarcinogenesis and the frequent loss of the proline allele in HCV-associated carcinogenesis of the liver plays some critical role in hepatocarcinogenesis. Amazingly, there is a significant correlation between male homozygotes for P53 72Pro with HCV type 1b infection. However, there was no significant difference between the P53 polymorphism and HCV genotypes 2a and 2b. It was concluded that the P53 gene polymorphism at codon 72 has been investigated as potential risk factor in several cancer models and HCV infections. 相似文献
2.
Curcumin is a natural anti-inflammatory and antioxidant with several potential health benefits. Although it has been examined in several metals toxicity studies, but its role in the protection against copper toxicity has not been investigated. In this study; the detoxification and antioxidant effect of curcumin were examined to determine its prophylactic/therapeutic role experimentally in rats. Forty albino rats were divided into five groups; control, CuSO4 (4 mg/kg body weight), curcumin (80 mg/kg body weight), curcumin post-treatment (CuSO4 for 15 days followed by curcumin for the next 15 days) and curcumin co-treatment (CuSO4 plus curcumin for 30 days). All rats were treated orally by stomach tube for 30 days/once a day. Changes were observed in hepatic marker enzymes such as: aspartate aminotransferase (AST), alanine transaminase-(ALT), alkaline phosphatase (ALP) and gamma-glutamyltransferase (GGT), besides the serum total protein, urea and creatinine. Concentration of liver and kidney antioxidants such as: catalase (CAT), superoxide dismutase (SOD), reduced glutathione-(GSH) and malondialdehyde (MDA) were measured. An increased in the activities of liver marker enzymes, urea, creatinine and the MDA contents were detected after exposure to CuSO4. Meanwhile, the activities of serum total protein, hepatic and renal antioxidants were decreased. Changes in all biochemical parameters were alleviated by the post-treatment and co-treatment of curcumin. Our finding suggests that the curcumin showed protective effects on CuSO4-induced hepatotoxicity and nephrotoxicity. 相似文献
3.
The EIAH Metadata Application Profile (EMAP) has been designed to meet Encyclopedia of Iranian Architectural History (EIAH) needs regarding the organization of architectural resources. The application profile should satisfy community needs and should respect existing conventions; architects may think differently from archivists or museum curators. The key issues in the design process have been addressed here; namely, compliance with the special needs of EIAH data architecture, interoperability, compliance with Persian language and localization, as well as simplicity, critical because of the wide range of non-cataloger users of the system. The EMAP has been designed based on Dublin Core; six element refinements have been defined for the Dublin Core element “subject” to facilitate the interconnection of resources to entities in the EIAH ontology. In particular, human readable documentation guidelines have been emphasized as an important factor in metadata quality. Metadata crosswalks have also been defined with major standards of the domain to improve interoperability. 相似文献
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Emad Al-Hussaini Farid Badran Laurence Turner 《Journal of The Franklin Institute》1977,304(6):265-278
The performance of two-sample non-parametric detectors using dependent samples is considered. It is shown that in the situation in which square-law envelope detection is employed, the signals to be detected fluctuate in accordance with a chi-square distribution and the background interference is additive Gaussian noise; the two-sample Generalized Sign (GS), Mann-Whitney (MW), Modified Savage (MS) and Modified Rank Square (MRS) detectors have superior asymptotic processing times to those that are obtained when independent samples are used. Also, it is shown that in addition to the advantage of improved performance, detection using dependent samples can have implementation advantages as compared with detection based on the use of independent samples. 相似文献
6.
Policy as Boundary Object: A New Way to Look at Educational Policy Design and Implementation 总被引：1，自引：0，他引：1
Policy implementation research in general and educational policy in particular is loosely connected to policy-making processes.
There is a gap particularly in the field of vocational education. This often leads to conflicts and contradictions between
policy-maker objectives and end-user implementation. To avoid such a disconnect, the relation between the world of end users
and the world of decision-makers should be carefully constructed. This might be done through connecting the process of decision-making
to implementation and carefully developing methods that encompass the demands of decision-makers and the needs and informational
requirements of end users. Our intensive case study research on the process of a vocational education reform in the marine
sector confirms that the lack of robust connection and active engagement of implementers as the end-users in the design of
the policy created challenges for its implementation. Using a theoretical framework based on the notion of boundary objects we bring an alternative to current practice by creating the potential to illuminate and remove tensions and challenges for
policy implementation. From there we infer that adopting this concept for policy design may prevent such conflicts and contradictions
and result in successful implementation.
相似文献
| Wolff -Michael RothEmail: |
7.
In this article, Dr Emad M. Alghazo and Dr Eman El. Naggar Gaad, both assistant professors at the Department of Special Education in the United Arab Emirates University, report on their research into the attitudes of mainstream teachers towards the inclusion of students with disabilities. The research took place in the Emirate of Abu-Dhabi, the capital of the United Arab Emirates, and set out to explore the extent to which general education teachers there accept the inclusion of students with disabilities in mainstream classrooms. The research process incorporated a questionnaire survey, analysed quantitatively, and a series of interviews with teachers to follow up on a range of issues. The analysis of the results takes account of a number of variables, including the gender of the respondents; number of years' experience as a teacher; and type of learner disability. Emad Alghazo and Eman Naggar Gaad report that there is more work to be done on the development of an 'inclusion culture' among teachers in the United Arab Emirates. They close their article by making a series of recommendations for future practice focusing on initial teacher education, continuing professional development and attitudinal change. 相似文献
8.
Emad Y. Moawad 《Indian journal of clinical biochemistry : IJCB》2014,29(4):491-495
The goal of this work is to determine the role of the autoimmune cells in multiple sclerosis (MS) induction and the immunomodulatory mechanism of therapy with tyrosine kinase inhibitors (TKIs) in MS attenuation. Samples (5 × 105 cells per well) of C6 and primary rat astrocytes were stimulated with 10 ng/mL of platelet-derived growth factor (PDGFbb) as a positive control forming a mouse model of MS. PDGFbb was added to the astrocytes in the absence or presence of 0.1 and 1 μM of imatinib. Proliferation of C6 and primary rat astrocytes samples were assessed for samples staging by the addition of 1 μCi of 3H-thymidine per well. Samples of RAW 264.7 cells were stimulated for 48 h with 10 ng/mL of PDGFbb in the absence or presence of 0.1 and 1 μM of sorafenib. Tumour necrotic factor (TNF) levels in culture supernatants from RAW 264.7 cells were measured by ELISA. The histologic grade (HG) and the level of TNF of the mouse model of MS was 1/5 and 5 times respectively of those in the control one to clarify that MS induction is due to a major decrease in HG inversely proportional to the accompanied increase in TNF level perpetuating local inflammation and demyelination in MS lesion. The addition of 0.1 and 1 μM doses of imatinib increased HG of the mouse model of MS by 6 and 11 times respectively while 0.1 and 1 μM doses of sorafenib decreased TNF level to be 1/2 and 1/5 of that in the mouse model of MS respectively restoring normal rate of TNF level of normal lesion to show that HGand TNF level would be strongly inversely correlated (r = −0.99) in attenuating MS effectively by TKIs therapy but not in an inverse proportion as in MS induction. 相似文献
9.
Emad E. Mahmoud 《Journal of The Franklin Institute》2012,349(3):1247-1266
In this paper we present the adaptive anti-lag synchronization (ALS) of two identical or non-identical hyperchaotic complex nonlinear systems with uncertain parameters. The concept of ALS is not detected yet in the literature. Based on the Lyapunov function a scheme is designed to achieve ALS of hyperchaotic attractors of these systems. The ALS of two identical complex Lü systems and two different hyperchaotic complex Lorenz and Lü systems are taken as two examples to verify the feasibility of the presented scheme. These hyperchaotic complex systems appear in several applications in physics, engineering and other applied sciences. Numerical simulations are calculated to demonstrate the effectiveness of the proposed synchronization scheme and verify the theoretical results. 相似文献
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Education and Information Technologies - In recent years, game-based student response systems (GSRS) such as Socrative, Quizlet, and Kahoot! has become a popular tool to increase motivation,... 相似文献