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Meera S. Ghadge Purva P. Naik Bijaynath P. Tiwari Ruprekha M. Hegde Tanaji J. Matale 《Indian journal of clinical biochemistry : IJCB》2012,27(1):97-99
Breast cancer is one of the most frequent malignancies in the world. Available staging procedures to detect breast cancer
are bone scan, chest X-ray, liver ultrasonography, computerized tomography, estimation of tumor markers like carbohydrate
antigen (CA15-3) and carcino embryonic antigen. These procedures are expensive and may not be required in all cases. Out of
70 patients studied, 55 had normal CA15-3 and 15 had elevated levels of Ca15-3. Eight (14.5%) of the 55 patients with normal
CA15-3 had abnormal bone scan. Fifteen patients had CA15-3 levels above the normal range and among these 9 (60%) had abnormal
bone scan. While prime facie it would appear that a high level of CA15-3 correlate with abnormal bone scan, it is also true
that the numbers are small at present and conclusions about the validity of CA15-3 as marker of bone metastasis may be premature. 相似文献
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Quality in Inclusive Preschool Classrooms 总被引：1，自引：1，他引：0
Linda L. Hestenes Deborah J. Cassidy Jonghee Shim Archana V. Hegde 《Early education and development》2013,24(4):519-540
Research Findings: Quality of care for preschool children in inclusive and noninclusive classrooms was examined in two studies. In Study 1, comparisons across a large sample of classrooms (N = 1, 313) showed that inclusive classrooms were higher than noninclusive classrooms in global quality as well as on two dimensions of quality (Activities/Materials and Language/Interactions). In Study 2, a more diverse sample of 44 classrooms (20 inclusive and 24 noninclusive) did not reveal differences on the global measures of quality but did show a difference on a measure of teacher–child interactions. Teachers in inclusive classrooms had higher quality and more appropriate interactions with all children than did teachers from noninclusive classrooms. Ratings of perceived severity of children's disabilities were not related to any of the measures of classroom quality in either study. Practice or Policy: Both studies suggest that including children with disabilities in regular preschool classrooms does not result in lower quality programs or in less adequate teacher–child interactions, particularly for children with mild to moderate disabilities. Results illustrate the importance of continued education for early childhood professionals on high-quality teacher–child interactions. Faculty in personnel preparation programs as well as policymakers need to continue to promote high-quality interactions between teachers and children. 相似文献
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Afzal Ahmad Rukmini Mysore Srikantiah Charu Yadav Ashish Agarwal Poornima Ajay Manjrekar Anupama Hegde 《Indian journal of clinical biochemistry : IJCB》2016,31(4):458-462
The cause of more insulin resistance in female than males are still unknown. To know the cause from early life, normal values of relevant parameters are required. So, aim of this study was to determine the reference levels of glucose and insulin in cord blood of term newborns and to examine their effects on gender, placental and birth weight of term newborns. In cross sectional study 60 consecutive term newborns were included from constituent hospitals. Placental and birth weights were measured and cord blood was collected for estimation of serum insulin and plasma glucose. Plasma glucose estimation was done by auto analyzer (GOD–POD method) and serum insulin analysis was done using Insulin ELISA Kit. After analysis, mean ± 2SD used for estimating cord blood insulin and glucose levels, which were 10.1 ± 7.8 μIU/mL and 67.8 ± 33.8 mg/dL respectively. Correlation of insulin with both birth weight and placental weight were r = 0.359 and 0.41 respectively; p < 0.001. Interestingly we found higher insulin levels in females as compared to male newborns in spite of having lower birth weight in them. In conclusion this study reported the levels of insulin and glucose in cord blood of term newborns. Incidentally, this is the first study as per our knowledge to report significant correlation between cord blood insulin, glucose with birth weight, placental weight and gender in south India. Female newborns had higher insulin levels than males, despite lesser birth weight can be attributed to intrinsic insulin resistance in them. 相似文献
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Designing online courses: A taxonomy to guide strategic use of features available in course management systems (CMS) in distance education 总被引：2，自引：1，他引：2
Course developers can be distracted from applying sound instructional design principles by the amount of flexibility offered through online course development resources (<citeref rid="b16">Kidney & Puckett, Quarterly Review of Distance Education, 4 (2003)</citeref>, 203-212). Distance education course management systems (CMS) provide multiple features that can be easily integrated into online instruction. Easy integration does not equal good design, and poor design can impede learning (<citeref rid="b15">Kearsley, A guide to online education (1997)</citeref> http://gwis.circ.gwu.edu/～etl/online.html). A taxonomy of the instructional value for CMS features is described. An example of how a course was translated into an online version, initially a failure, and redesigned using this taxonomy is presented. A taxonomy that strategically guides the use of appropriate CMS features to integrate informational, instructional, and learning elements into online courses can support designers in the development of quality of online instruction. 相似文献
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Aniket V. Mali Sunita S. Bhise Surendra S. Katyare Mahabaleshwar V. Hegde 《Indian journal of clinical biochemistry : IJCB》2018,33(1):38-45
Recent studies have been noted that the erythrocytes from Type II diabetic patients show significantly altered structural and functional characteristics along with the changed intracellular concentrations of glycolytic intermediates. More recent studies from our laboratory have shown that the activities of enzymes of glycolytic pathway changed significantly in RBCs from Type II diabetic patients. In particular the levels of lactate dehydrogenase (LDH) increased significantly. Lactic acidosis is an established feature of diabetes and LDH plays a crucial role in conversion of pyruvate to lactate and reportedly, the levels of lactate are significantly high which is consistent with our observation on increased levels of LDH. Owing to this background, we examined the role of erythrocyte LDH in lactic acidosis by studying its kinetics properties in Type II diabetic patients. Km, Vmax and apparent catalytic efficiency were determined using pyruvate and NADH as the substrates. With pyruvate as the substrate the Km values were comparable but Vmax increased significantly in the diabetic group. With NADH as the substrate the enzyme activity of the diabetic group resolved in two components as against a single component in the controls. The Apparent Kcat and Kcat/Km values for pyruvate increased in the diabetic group. The Ki for pyruvate increased by two fold for the enzyme from diabetic group with a marginal decrease in Ki for NADH. The observed changes in catalytic attributes are conducive to enable the enzyme to carry the reaction in forward direction towards conversion of pyruvate to lactate leading to lactic acidosis. 相似文献
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Deborah J. Cassidy Linda L. Hestenes Joanna K. Hansen Archana Hegde Jonghee Shim Steve Hestenes 《Early education and development》2005,16(4):505-520
While child care quality has been examined in numerous studies, the definition of quality and specifically, the concepts of structural and process quality, have not been adequately explored. In this qualitative analysis of the constructs of process and structural quality, a content analysis of the Early Childhood Environment Rating Scale-Revised (ECERS-R), a commonly used measure of process quality, was conducted to investigate its use as a measure of process quality. Through constant comparative analysis of the ECERS-R at the indicator level, definitions of structure and process were formulated. Results show that over half of the indicators of the ECERS-R are measuring structural quality rather than process quality. Further examination of quality as a dynamic exchange between individuals and context is needed to advance research in the area of early childhood program quality. 相似文献
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The authors examine how counselor educators can become involved in professional development schools to create enhanced training opportunities for school counseling internship students. The benefits of collaboration between university and public school faculties are explored, and research opportunities are discussed. Counselor educators' expertise in research and program evaluation, combined with school counselors' pragmatic experience in dealing with real‐life issues, may promote best practices in the schools and improved training for school counselors and can set the stage for collaboration as an educational team at the preservice level. 相似文献
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Linda Crane Mitchell Archana V. Hegde 《Journal of Early Childhood Teacher Education》2013,34(4):353-366
This study examined the beliefs of in-service teachers working in inclusive classrooms regarding developmentally appropriate practices and how those beliefs affected their attitudes toward, knowledge of, and comfort levels regarding working with children with disabilities. A mixed-method approach was utilized and data were collected through the use of three survey instruments: Teacher Belief Scale and Instructional Activities Scale (Hart et al., 1990) and the In-service Teacher Self-Report Survey (Mitchell, 2002). Data were also collected through open-ended questions to assess Teachers' perceived level of preparation for the inclusive classroom. This study also examined whether education or experience levels had an influence on Teachers' perceptions regarding inclusive practices. Results of the study indicate that there is not a significant relationship between in-service Teachers' beliefs regarding developmentally appropriate practices and their attitudes toward, knowledge of, and comfort levels regarding inclusion. Additionally, results indicate that the Teachers' levels of education or experience do not necessarily indicate that they are prepared to meet the needs of the inclusive classroom environment. Implications regarding the preparation of and ongoing training needs of teachers are discussed. 相似文献