Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

Mediated absent presence in forced displacement     

Mirjam A. Twigt 《Popular Communication》2019,17(2):171-184

ABSTRACT

For many forcefully displaced people worldwide, notions around one’s sense of “home” and “place” in the world are perpetually unsettled. This article explores how digital technologies interact with embodied, material experiences within the geographical location refugees are residing in. Empirical examples from ethnographic research conducted among Iraqi urban refugees, living in prolonged uncertainty in Jordan, shows how situated experiences of legal, material, and social uncertainty reinforce particular mediated socialities. Pivotal studies have shown how digital connections engender virtual home-making practices and a wide variety of connected presences. This study points to the other side of the same coin: the cultivation of “absent presence.” “Absent presence” refers to feelings—the ambivalence that experiences of prolonged displacement bring about—but also to active disengagement and affective tactics in response. These engender a further separation from the physical world where forced migrants are not deemed welcome.  相似文献   

Data Visualization as Participatory Research: A Model for Digital Collections to Inspire User-Driven Research     

A. Miller 《Journal of Web Librarianship》2019,13(2):127-155

The emerging creative practices of digital collections are increasing in prominence thanks to the access to, and appeal of, data visualizations. Interactive data visualizations, such as a map, timeline, chart, graph, or artist’s rendering of data, enable users to pursue their own research interests within a collection and participate in new areas of research. Use of these data visualizations enhances the scope of the collection and enables a modern and diverse thematic collection to emerge. This article considers the question: Does the addition of data visualizations affect how users participate with a research collection? Impacts on collection development, application of user-centered design, and analysis of users’ exploratory strategies are discussed. Examples of data visualizations used in digital humanities projects and digital collections are presented as case studies.  相似文献   

Getting What You Pay For: Children's Use of Market Norms to Regulate Exchanges     

Margaret Echelbarger  Susan A. Gelman  Charles W. Kalish 《Child development》2019,90(6):2071-2085

Children are sensitive to a number of considerations influencing distributions of resources, including equality, equity, and reciprocity. We tested whether children use a specific type of reciprocity norm—market norms—in which resources are distributed differentially based strictly on amount offered in return. In two studies, 195 children 5–10 years and 60 adults distributed stickers to friends offering same or different amounts of money. Overall, participants distributed more equally when offers were the same and more unequally when offers were different. Although sensitive to why friends offered different amounts of money, children increasingly incorporated market norms into their distributions with age, as the oldest children and adults distributed more to those offering more, irrespective of the reasons provided.  相似文献   

记忆场、传统村落与我们的责任——档案部门参与村落记忆场保护的价值与策略     

周林兴  林腾虹 《档案管理》2020,(3):39-41

传统村落拥有丰富的自然和文化资源,凝结着历史的记忆,是社会文明的直接见证者。随着城镇化进程的推进,传统村落逐步消融在时代的印迹里。为促进传统村落在新时代的焕发新生,文章借助法国历史学家皮埃尔·诺拉的记忆之场理论,指出传统村落在历史、时间、变迁中凝聚成具有象征意义的记忆场。在此基础上文章剖析了档案部门参与村落记忆场保护的意义,阐释了村落记忆场赓续乡村记忆、留住乡情乡愁、传承文化遗产的功能,并提出了档案部门就如何推动村落记忆场实现功能最大化的策略,以期使档案部门更好地承担起传承、保护、赓续传统村落的主体责任。  相似文献   

Editorial     

Rick Ostrander  Karen A. Longman 《Christian Higher Education》2019,18(1-2):1-2

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Medieval and renaissance glass technology in Valdelsa (Florence). Part 1: raw materials, sands and non-vitreous finds     

U. Casellato  F. Fenzi  P. Guerriero  S. Sitran  P. A. Vigato  U. Russo  M. Galgani  M. Mendera  A. Manasse 《Journal of Cultural Heritage》2003,4(4):337-353

A significant number of archaeological finds of the 13th–16th century from the Tuscan sites of Germagnana and Gambassi in Valdelsa—FI, was studied by different physico-chemical investigations (SEM–EDS, ICP, Mössbauer spectroscopy, XRD, XRF, TG-DTA) in order to contribute to clarify the production methodology and the pre-industrial glass manufacture technology. The studied samples are mainly non-vitreous finds as production waste, refractory materials, crucibles and raw materials; also vitreous finds as frits, skims, glasses (glass masses, glass working waste and finished products) have been taken into consideration. The obtained petrographic and physico-chemical data strongly suggest that both Gambassi and Germagnana glass manufactures were strictly connected with the sources of vitrifiable materials, situated in Tuscan sand quarries. In particular a comparison between sands from the neighbouring quarries and appropriate finds of the two archaeological sites evidences that the employed vitrifiable materials possibly belong to La Casina La Cava resort. The archaeological classification, based on macroscopic observation and stratigraphic position, was compared and verified with the scientific classification of the examined finds of Germagnana and Gambassi sites based on their composition, morphology and physico-chemical properties.  相似文献   

中国竞技体育人力资源相关问题探讨   总被引：5，自引：0，他引：5  

肖林鹏  赵云宏  张兆青  骆意 《广州体育学院学报》2003,23(6):8-9

对竞技体育人力资源的概念、特点等问题进行了探讨：研究表明，竞技体育人力资源是指竞技体育发展所需人员的现实及潜在禀赋的总和。处于不同层次、不同领域的众多人员组成了竞技体育人力资源系统：竞技人力资源具有稀缺性、目标性、整体性及调控性等特点.  相似文献   

马来西亚华文独中学校体育的现状与未来     

韩会君  林敏萍 《体育科研》2003,24(3):59-62

本着弘扬民族文化的基本思想,运用文献资料研究、问卷调查、数理统计等方法,对马来西亚华文独中学校体育的现状进行了客观的分析,并在现状分析的基础上对马来西亚华文独中学校体育的进一步发展提出了建设性的意见。  相似文献   

国内运动生物力学发展现状思考   总被引：5，自引：0，他引：5  

王今越  刘伟  陈民盛 《天津体育学院学报》2003,18(4):33-36

运动生物力学是一门新兴的边缘性科学，其定义、研究范畴、研究方法都有待商榷。从这三个角度出发，主要对大量资料进行归纳总结，综合、概括了目前国内运动生物力学发展状况。力求对我国的运动生物力学发展的状况勾勒出一个清晰的脉络图，以便在这门学科今后的研究中减少盲目性，具有更强的实用性。  相似文献