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1.
Working memory training improves children's cognitive performance on untrained tasks; however, little is known about the underlying neural mechanisms. This was investigated in 32 typically developing children aged 10–14 years (19 girls and 13 boys) using a randomized controlled design and multi-modal magnetic resonance imaging (Devon, UK; 2015–2016). Training improved working memory performance and increased intrinsic functional connectivity between the bilateral intraparietal sulci. Furthermore, improvements in working memory were associated with greater recruitment of the left middle frontal gyrus on a complex span task. Repeated engagement of fronto-parietal regions during training may increase their activity and functional connectivity over time, affording greater working memory performance. The plausibility of generalizable cognitive benefits from a neurobiological perspective and implications for neurodevelopmental theory are discussed.  相似文献   
2.
This paper uses Rittel and Webber’s categorisation of wicked problems in order to interrupt discourses around school behaviour. Each of the 10 characteristics suggested by Rittel and Webber are examined using the English education system as a vehicle by which to consider and interrogate their complexity. This endeavour is crucial as although the characteristics of wicked problems naturally overlap, the cannot, and should not, be conflated if we wish to understand how different facets of a wicked problem shed light, and create shadows, that impact on all members of a school community. That school communities can be wicked settings adds nuance to the complexity of the problems that we face when educating students whose behaviours challenge the norms of their educational environment.  相似文献   
3.
It is generally acknowledged that expatriate British players and coaches were instrumental in soccer’s radiant global diffusion and that different technical and tactical emphases developed according to particular geographical locations and cultural milieu. As the twentieth century unfolded, the trend reversed with increased inward flows of elite foreign playing and coaching labour challenging the distinctive and erstwhile dominant occupational culture of the English game. This paper explores the dynamics and tensions of subcultural modification and adaptation at the British: migrant coaching talent interface. Owing to issues associated with access, the occupational subculture of elite-level football is impenetrable to most researchers. Previous employment in professional soccer allowed this author to overcome such impediments, permitting access to a range of high-status national and international players and coaches (n = 25) affecting and affected by occupational subcultural change. This enabled a distinctive research platform combining insider knowledge and grounded experience with academic orthodoxy. The paper is built upon primary data collected in semi-structured interviews and critical analysis of emerging themes. In doing so, it offers a fresh dimension to understanding the impact of globalization on elite professional English soccer. Key findings indicated the opinion of British coaches on the impact of this foreign influx polarized. Although many demonstrated an enlightened standpoint, adopting innovative practices introduced by overseas coaching talent, these views were counter-balanced by evidence of a myopic arrogance bordering on xenophobic resistance to change in what now has to be considered the global rather than the ‘English’ game.  相似文献   
4.
This article examines a recurrent film motif across a number of South Asian films, mostly called Mela. It also offers some observations on melas, actual and allegorical, as represented in films but often seeming to exceed their containment in context so as to say more about the conviviality of life, where this is at issue, where life is at a juncture in need of resolution within the cycle of becoming. The issues of violence, loss, national identity, politics of interpretation and repetition in ideology are canvassed. While the essay is focused upon Mela films themselves, and South Asian film more broadly, it has of course been important to note work by scholars such as M. Madhava Prasad, Ashish Rajadhyaksha, Anjali Gera Roy, Tejaswini Niranjana, Gayatri Chakravorty Spivak and the help of my students, some of whom are named below.  相似文献   
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Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   
7.
In this digital ITEMS module, Dr. Jeffrey Harring and Ms. Tessa Johnson introduce the linear mixed effects (LME) model as a flexible general framework for simultaneously modeling continuous repeated measures data with a scientifically defensible function that adequately summarizes both individual change as well as the average response. The module begins with a nontechnical overview of longitudinal data analyses drawing distinctions with cross-sectional analyses in terms of research questions to be addressed. Nuances of longitudinal designs, timing of measurements, and the real possibility of missing data are then discussed. The three interconnected components of the LME model—(1) a model for individual and mean response profiles, (2) a model to characterize the covariation among the time-specific residuals, and (3) a set of models that summarize the extent that individual coefficients vary—are discussed in the context of the set of activities comprising an analysis. Finally, they demonstrate how to estimate the linear mixed effects model within an open-source environment (R). The digital module contains sample R code, diagnostic quiz questions, hands-on activities in R, curated resources, and a glossary.  相似文献   
8.
ABSTRACT

This forum brings together food, (in)security, and communication. The authors participating in this forum center communication as both process and tool for understanding, mitigating, and making meaning of food (in)security. The nine authors together discuss the role of communication in food (in)security, the central challenges for scholars and practitioners working on food (in)security, and the creative possibilities and impacts influencing the future of food (in)security. The forum produces a call for applied scholars to re-imagine communication frameworks in order to make meaningful differences in their communities.  相似文献   
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