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Scott Ailliet Rik Vandenberghe Toon Schiemsky Lode Van Overbeke Philippe Demaerel Wouter Meersseman David Cassiman Pieter Vermeersch 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2022,32(2)
Vitamin B12 deficiency can present with neurologic and psychiatric symptoms without macrocytic anaemia. We describe a case of late-onset cobalamin C deficiency which typically presents with normal serum vitamin B12 concentrations, posing an additional diagnostic challenge. A 23-year-old woman with decreased muscle strength and hallucinations was diagnosed with ‘catatonic depression’ and admitted to a residential mental health facility. She was referred to our hospital for further investigation 3 months later. Heteroanamnesis revealed that the symptoms had been evolving progressively over several months. Magnetic resonance imaging (MRI) of the brain showed diffuse symmetrical white matter lesions in both hemispheres. Routine laboratory tests including vitamin B12 and folic acid were normal except for a slight normocytic, normochromic anaemia. Over the next 6 weeks her symptoms deteriorated, and she became unresponsive to stimuli. A new MRI scan showed progression of the white matter lesions. The neurologist requested plasma homocysteine (Hcys) which was more than 8 times the upper limit of normal. Further testing revealed increased methylmalonic acid and the patient was diagnosed with adult-onset cobalamin C deficiency. This case illustrates that Hcys and/or methylmalonic acid should be determined in patients presenting with neuropsychiatric symptoms suggestive of vitamin B12 deficiency with a normal serum vitamin B12 to rule out a late-onset cobalamin C deficiency. 相似文献
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Juliette Langlois Guylaine Mary Hélène Bluzat Agnès Cascio Nathalie Balcar Yannick Vandenberghe 《文物保护研究》2017,62(5):247-265
Prior to the exhibition Portrait-making, Rodin and his models (2009), the Rodin museum wanted to restore two busts of Hanako and Clemenceau. Interestingly, these two sculptures contain pieces of modern modeling materials (MMMs) invented at the end of the nineteenth century as an alternative to clay or waxes. The poor state of conservation of the two portraits made any handling and exhibition impossible. Accordingly, the purpose of this article is twofold: to contribute to technical art history and conservation. Elemental and chemical analyses were done on samples from 12 sculptures (SEM–EDX, FTIR, GC–MS, GC–FID, XRD, synchrotron-based µXRF, µXANES, and µFTIR) aimed at identifying the composition of MMMs used by Rodin on plaster sculptures and establishing hypotheses about the origins of their degradation. This thorough study of their composition and degradation was necessary to implement an appropriate restoration plan. The development of conservation protocols adapted to such materials is rarely documented. Different tests were performed on mock-ups (pH, solubility, adhesion, consolidation, and cleaning). In particular, a protocol based on laser cleaning was developed and successfully applied to remove superficial dust and crusts so that the sculptures regained their original aspect. 相似文献
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ABSTRACTTwo Spiritelli attributed to Donatello have been extensively studied from a technical point of view, including X-radiography, alloy analysis, characterization of the core, and visual observations on the interior and exterior of the statues. The results of this technical study reveal how the two statues were cast and document the artist’s technical choices. These new insights offer additional information to address questions regarding their attribution, production context, and conservation history. First, the technical study confirmed that the statues were made by the same workshop and argues against the prior proposal of different attributions for the two figures. Second, the results strongly suggest that the statues have never been separated since they were taken off Luca Della Robbia’s Cantoria. Finally, study of the two Spiritelli offers further evidence of the heterogeneity and ingeniousness of Donatellos bronze artistic production, and contributes to the ongoing debate whether the artist himself was involved in the technical aspects of his sculpture. 相似文献
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Rudolf van den Berg Roland Vandenberghe Peter Sleegers 《School Effectiveness & School Improvement》2013,24(3):321-351
The history of education and schooling is characterised by not only the attainment of results but also ongoing critique of the existing situation in education and schooling. Developers and researchers are, as a result, constantly seeking new strategies and methods for the improved implementation of innovations in actual educational practice. The central question is which factors and which conditions facilitate the effects of innovations. In an attempt to answer this question, many educators will not so much be concerned with objective structural factors such as available funds, classmates, et cetera. They will be concerned, rather, with the questions of which socially constructed realities and which particular forms of involvement on the part of teachers, school administrators, and counsellors facilitate successful innovation. In our search for an answer to these questions, moreover, we will be guided by a cultural-individual perspective on innovation. Traditional innovative strategies – and, in particular, large scale strategies – seem not always suitable to deal with today's educational problems. Alternative scenario's for the management of innovations are considered. 相似文献
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What does it take to achieve equality of opportunity in education?: An empirical investigation based on Brazilian data 总被引：1，自引：0，他引：1
Roemer's [Roemer, J. (1998). Equality of opportunity. Cambridge, MA: Harvard University Press.] seminal work on equality of opportunity has contributed to the emergence of a theory of justice that is modern, conceptually clear and easy to mobilize in policy design. Inspired by Roemer's theory, this paper is fundamentally a policy-modeling exercise coupled to a micro data analysis. In a pure allocation setting, we first analyze the reallocations of educational expenditure required to equalize opportunities (taken to be test scores close to the end of compulsory education). Using Brazilian data, we find that implementing an equal-opportunity policy across pupils of different socio-economic background, by using per-pupil spending as the instrument requires multiplying by 6.8 on average the current level of spending on the lowest achieving pupils. This result is driven by the extremely low elasticity of scores to per-pupil spending. We then show that the simultaneous redistribution of monetary and non-monetary inputs, like peer group quality and school effectiveness, considerably reduces—by around 23%—the magnitude of financial redistribution needed. 相似文献
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Vincent Vandenberghe 《比较教育学》1999,35(3):271-282
This article focuses on institutional arrangements in education across Western countries. It essentially deals with the recent trend towards extended school choice presumably aimed at creating a competitive environment for schools and teachers. For many years the functioning of educational systems, in particular the way schools were institutionally co-ordinated, was not perceived as fundamental to economic analysis. But more and more economists now believe that the institutional setting in which schools are embedded-their governance structure-is decisive regarding both efficiency and equity. In this respect, it is worth noting that most Western countries rely essentially on bureaucratic control to co-ordinate their educational sector. Yet some of them, such as Belgium, The Netherlands, England and Wales, New Zealand and Sweden incorporate market-oriented mechanisms at the heart of their institutional arrangements. The main focus of this article is to analyse the origins, as well as the economic relevance, of this-in some cases relatively recent-tendency to mix bureaucratic and market approaches to education. 相似文献
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He-Chuan Sun Roland Vandenberghe Bert Creemers 《International journal of qualitative studies in education》2013,26(2):233-250
This paper explores higher education reforms in China in the 1990s. Confronted with the furious conflicts and mismatch between the market economy and the highly state-controlled socialist educational system, educational reforms in China are extremely complex and difficult. The authors present a case study here telling the tragedy of a university president's reforms in China. They have unfolded how the macro system changes impacted on the micro system reforms. They point out that multilayers exist within an organizational culture. Although understanding organizational culture does not guarantee successful reform, however, a thorough understanding of the fabric of an organizational culture may become an effective lever to initiate or implement the context-fitted reforms. The authors try to describe informatively what dilemmas the Chinese IHE leaders were faced with in the 1990s. Seeking new means for school reforms in a time of turbulent policy environment, in a testing period with sharp contradictory forces, school leaders should have not only sharp eyes, clear thinking, and independence but also creativity, endurance, and persistence. 相似文献
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Pol Ghesquière Roland Vandenberghe 《International Journal of Disability, Development & Education》2004,51(2):171-184
Research on special needs education is often very complex and puts specific demands on the methodology used. Data‐triangulation, at the very least, is required. In most of our recent research projects on the development of special needs education in Flanders (the Dutch speaking part of Belgium), we have made use of qualitative case studies to describe and understand the complex reality of the innovations taking place in our schools. In this article we discuss some methodological aspects of qualitative case study designs, illustrated with a study on the implementation of inclusive education in Flemish primary schools. 相似文献
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