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Krishnan Gokuladhas Subramaniyan Jayakumar Balan Rajan Ramasamy Elamaran Chengalvarayan Subramani Pramila Mani Gopikrishnan Sasivarman Tamilarasi Thiruvengadam Devaki 《Indian journal of clinical biochemistry : IJCB》2016,31(2):171-184
Liver cancer is the fifth most common cancer and is still one of the leading causes of death world wide, due to food additives, alcohol, fungal toxins, air, toxic industrial chemicals, and water pollutants. Chemopreventive drugs play a potential role in liver cancer treatment. Obviously in the production of anticancer drugs, the factors like poor solubility, bioavailability, biocompatibility, limited chemical stability, large amount of dose etc., plays a major role. Against this backdrop, the idea of designing the chemopreventive nature of bio flavanoid hesperetin (HP) drug conjugated with pegylated gold nanoparticles to increasing the solubility, improve bioavailability and enhance the targeting capabilities of the drug during diethylnitrosamine (DEN) induced liver cancer in male wistar albino rats. The dose fixation studies and the toxicity of pure HP and HP conjugated gold nanoparticles (Au-mPEG(5000)-S-HP) were analysed. After concluded the dose fixation and toxicity studies the experimental design were segregated in six groups for the anticancer analysis of DEN induced HCC for 16 weeks. After the experimental period the body weight, relative liver weight, number of nodules and size of nodules, the levels of tumor markers like CEA, AFP and the level of lipid peroxidation, lipid hydroperoxides and the activities of antioxidant enzymes were assessed. The administration of DEN to rats resulted in increased relative liver weight and serum marker enzymes aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, and gamma glutamyl transpeptidase. The levels of lipid peroxides elevated (in both serum and tissue) with subsequent decrease in the final body weight and tissue antioxidants like superoxide dismutase, catalase, reduced glutathione, glutathione peroxidise, and glutathione reductase. HP supplementation (20 mg/kg b.wt) significantly attenuated these alterations, thereby showing potent anticancer effect in liver cancer and the HP loaded gold nanoparticels (Au-mPEG(5000)-S-HP) treated animals shows the better treatment than the pure HP due to the solubility of drug, bioavailability and the target drug delivery of the biodegradable polymer. Histological observations were also carried out, which added supports to the chemopreventive action of the pure HP and HP loaded gold nanoparticles (Au-mPEG(5000)-S-HP) against DEN induction during liver cancer progression. These findings suggest that HP loaded gold nanoparticels (Au-mPEG(5000)-S-HP) shows better efficacy than the pure HP against lipid peroxidation, hepatic cell damage and protects the antioxidant system in DEN induced hepatocellular carcinogenesis. 相似文献
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Raghuraman Sivalingam Subramani Chinnamuthu Subhransu Sekhar Dash 《Journal of The Franklin Institute》2017,354(12):4762-4783
This paper proposes to use a hybrid Stochastic Fractal Search (SFS) and Local Unimodal Sampling (LUS) based multistage Proportional Integral Derivative (PID) controller consisting of Proportional Derivative controller with derivative Filter (PDF) plus (1 + Proportional Integral) for Automatic Generation Control (AGC) of power systems. Initially, a single area multi-source power system consisting of thermal hydro and gas power plants is considered and parameters of Integral (I) controller is optimized by Stochastic Fractal Search (SFS) algorithm. The superiority of SFS algorithm over some recently proposed approaches such as optimal control, Differential Evolution (DE) and Teaching Learning Based Optimization (TLBO) is demonstrated. To improve the system performance further, LUS is subsequently employed. The study is further extended for different controllers like PID, and proposed multistage PID controller and the superiority of multistage PID controller over conventional PID controller structure is demonstrated. The study is further extended to a two-area six unit multi-source interconnected power system and the superiority of proposed approach over, TLBO and optimal control is demonstrated. Finally the study is extended to a three unequal area system power system with appropriate nonlinearities such as Generation Rate Constraint (GRC), Governor Dead Band (GDB) and time delay. From the analysis, it is found that hybrid SFS–LUS algorithm is superior to the original SFS algorithm and substantial improvement in system performance are realized with proposed multistage PID controller over conventional PID controller structure. 相似文献
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Pramila Rajbhandari John Wilmut 《Assessment in Education: Principles, Policy & Practice》2000,7(2):255-269
The operation and quality of assessment activities and procedures is closely bound up with the wider educational, economic and social infrastructure of a country. This paper reviews educational assessment in one of the world's poorest countries, and discusses the factors that determine how assessment and examinations are structured, and how their outcomes are used. The authors describe developments that have sought to bring about change and improvement, and review the factors that continue to limit these developments, whilst recognising the enormous progress that has already been made. 相似文献
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Manorama Swain Preetam Nath Prasant Kumar Parida Jimmy Narayan Pradeep Kumar Padhi Girish Kumar Pati Ayaskanta Singh Bijay Misra Debasis Misra Sanjib Kumar Kar Manas Kumar Panigrahi Chudamani Meher Omprakash Agrawal Niranjan Rout Kaumudee Pattnaik Pallavi Bhuyan Pramila Kumari Mishra Shivaram Prasad Singh 《Indian journal of clinical biochemistry : IJCB》2017,32(3):306-314
Aminotransferase assay is often used as a screening test as well as an endpoint for resolution of disease in nonalcoholic fatty liver disease (NAFLD). Aim of the study was to evaluate the relationship of transaminase level with metabolic variables and histology in NAFLD. Single center observational study was conducted in a gastroenterology clinic at Cuttack in coastal Odisha. Subjects were consecutive patients presenting with functional bowel disease and undergoing abdominal sonography. All participants were evaluated for the presence of metabolic syndrome (MS), insulin resistance, liver function test and lipid profile. Various parameters were compared between NAFLD subjects and controls. 53.5 % of NAFLD had normal serum transaminases, whereas 20.8 % of healthy controls had transaminitis. NAFLD patients had significantly higher BMI, fasting plasma glucose, serum transaminases, serum triglycerides, serum insulin and homeostatic model assessment (HOMA) IR than controls. NAFLD patients who had transaminitis had significantly higher incidence of MS and higher mean HOMA IR than those without. There was no significant difference in histopathological features between NAFLD with and without transaminitis. To conclude, over half of NAFLD subjects do not have transaminitis while transaminitis is present in a fifth of healthy people without fatty liver. Hence serum transaminase should not be used as screening test for NAFLD. NAFLD patients with transaminitis had a higher incidence of MS and insulin resistance than those without. However, there was no significant difference in histopathological features between these two groups. 相似文献
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Yadav A Jyoti P Jain SK Bhattacharjee J 《Indian journal of clinical biochemistry : IJCB》2011,26(2):193-196
The increasing incidence of obesity, leading to metabolic complications is now recognized as a major public-health problem.
Insulin resistance is a central abnormality of the metabolic syndrome, or syndrome X, originally hypothesized by Reaven Insulin
resistance is more strongly linked to intra abdominal fat than to fat in other depots. Adipose tissue secretes numerous factors
(adipokines) known to markedly influence lipid and glucose/insulin metabolism, oxidative stress, and cardiovascular integrity.
Some of these adipokines have been shown to directly or indirectly affect insulin sensitivity through modulation of insulin
signaling and the molecules involved in glucose and lipid metabolism. A pilot study was conducted with 80 healthy subjects
who were non diabetic, non hypertensive and having no family history of hypertension, the aim was to evaluate the correlation
of adiponectin and leptin levels with obesity and insulin resistance markers in healthy north Indian adult population. Serum
leptin, adiponectin and insulin was estimated by sandwich ELISA method. In our study, Leptin correlated significantly with
BMI (P value of 0.0000), WC (P value = 0.007), and HC (P value = 0.000). leptin showed significant positive correlation with fasting insulin (P value 0.002), post prandial insulin (P value = 0.000) and HOMA-IR (P value = 0.002). Adiponectin showed significant positive correlation with triglycerides (P value = 0.038), strong negative correlation with HDL-cholesterol (P value = 0.017). Serum concentrations of leptin are associated with central body fat distribution. Insulin resistance and
adiponectin is associated with dyslipidemia and these all disorders may ultimately lead to metabolic syndrome. 相似文献
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Rachita Nanda Pramila K. Mishra U. K. Das S. B. Rout P. C. Mohapatra A. Panda 《Indian journal of clinical biochemistry : IJCB》2004,19(1):93-96
Serum malondialdehyde was measured in sixty-one falciparum malaria cases, which include thirty uncomplicated, and thirty-one
complicated with acute renal failure. Twenty-six healthy individuals were also studied as controls. Serum malondialdehyde
level was found to be significantly elevated in falciparum malaria induced acute renal failure cases when compared with uncomplicated
falciparum malaria (p<0.001) and healthy controls (p<0.001). A positive correlation with the raised urea, creatinine and bilirubin
levels were significant (r=0.62, p<0.025; r=0.65, p<0.05 and r=0.72, p<0.001 respectively) indicating the severity of complication
with rise of lipid peroxides in falciparum malaria induced acute renal failure cases. 相似文献
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