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In this section of Resonance, we invite readers to pose questions likely to be raised in a classroom situation. Wemay suggest strategies for dealingwith
them, or invite responses, or both. “Classroom” is equally a forum for raising broader issues and sharing personal experiences
and viewpoints on matters related to teaching and learning science. 相似文献
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Khan S Bhargava A Pathak N Maudar KK Varshney S Mishra PK 《Indian journal of clinical biochemistry : IJCB》2011,26(2):161-168
The present study evaluated the plausible role of circulating biomarkers in immune pathogenesis of chronic hepatitis considered
a priority in clinical hepatology. Total viral load of chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) patients
was quantified and correlation studies were performed with circulating levels of Th1/Th2 cytokines; C reactive protein and
circulating nucleosomes; glutathione reductase (GR) and superoxide dismutase. To our knowledge, the study is first among its
kind that validates strong positive correlation of viral load with IL-4, IL-6, GR in HBV and IL-6, IL-10, GR in HCV infections.
Although, multi-centric studies including large cohorts are required for translating our findings to clinical practice, however,
role of these biomarkers with potential diagnostic or prognostic significance might be helpful in clinical assessment of high-risk
individuals, thereby, designing interventional strategies, towards development of personalized medicare. The results of our
study also offer valuable insights of immune signaling mediators engaged in development of hepatocellular carcinoma. 相似文献
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Depletion of the Earth’s ozone layer is one of the major environmental concerns for the new millennium having serious implications on human health, agriculture and climate. In the past decades, research by the international scientific community has been directed towards understanding the impact of human interference on the Earth’s atmosphere. The importance of ozone radiation absorption in the atmosphere and the general kinetics of the stratospheric ozone depletion mechanisms have motivated many theoretical and experimental studies on various chemical species. The distribution of ozone and other trace gases in the atmosphere is governed by the complex interaction of dynamical, chemical and radiative processes. This article concentrates on the basic concepts underlying the problems that may be faced by humankind due to reduction in the ozone layer in coming decades, and the ways in which the scientific community can contribute to predicting and remediating these effects through design of international treaties, regulations and amendments. 相似文献
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The purpose of this study was to create a substantial body of knowledge about the factors that influence the success of electronic journals, and to share this knowledge with that in the fields of astronomy and astrophysics in order to help facilitate change.Structured questionnaires for users (Academic Members, Post-Doctoral Fellows and Research Scholars) containing 40 different questions, many of which were further subdivided and framed in order to get information on various aspects of the usage of electronic journals. The purpose was to identify the basic minimum infrastructure necessary to provide users access to electronic journals and to facilitate easy response in all major A&A organizations in India.The increasing use of the electronic information-seeking environment has produced changes in the practice of science. Significant research has been conducted already on the impact of new information and communication technologies on scholarly work.This study was limited to astronomy and astrophysics libraries and information centres in India.This paper identifies the information needs of the users. Each community and discipline has its own specific legacy of journal structure, reading, publishing, and researching practices, and it will take trial and error to establish which kinds of e-journals are the most effective and useful.Case study. 相似文献
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D. S. Dhiman N. K. Sarin R. K. Sharma J. R. Kanwar R. M. Pathak R. L. Gupta 《Indian journal of clinical biochemistry : IJCB》1989,4(1):23-25
The present study has been conducted in 80 cases, out of which 28 were of strangulated and 52 of non-strangulated intestinal
obstruction. It has been observed that serum lactate dehydrogenase of more than 300 I. U./litre in first 24 hours to 72 hours
is highly suggestive of strangulated intestinal obstruction. 相似文献
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This article describes a challenging problem concerning a neutron under gravity that was posed as a theoretical problem in
the 36th International Physics Olympiad held in Salamanca, Spain from July 3–12, 2005. The Olympiad marked India’s eighth
foray into this exciting event where seventyfive nations participated. Our performance was a success and all five student
members of the team secured medals which included two gold, two silver and one bronze medals. 相似文献
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Saba Khan Gorantla V. Raghuram Neelam Pathak Subodh K. Jain Dolly H. Chandra Pradyumna K. Mishra 《Indian journal of clinical biochemistry : IJCB》2014,29(1):38-44
Increased leukocyte apoptosis is intrinsically linked to disease patho-physiology, susceptibility to and severity of infections in type 2 diabetes mellitus (T2DM) patients. A consistent defect in neutrophil function is considered central to this increased risk for infections. Although redox imbalance is considered a potential mediator of these associated complications, detailed molecular evidence in clinical samples remains largely undetected. The study consisted of three groups (n = 50 each) of Asian Indians: early diagnosed diabetic patients, cases with late-onset diabetic complications and age and gender-matched healthy controls. We evaluated mitochondrial oxidative stress, levels of nuclear DNA damage and apoptosis in peripheral blood neutrophils isolated from T2DM patients. We observed that in both early and late diabetic subjects, the HbA1c levels in neutrophils were altered considerably with respect to healthy controls. Increased oxidative stress observed in both early and late diabetics imply the disentanglement of fine equilibrium of mitochondria-nuclear cross talk which eventually effected the augmentation of downstream nuclear γH2AX activation and caspase-3 expression. It would be overly naïve to refute the fact that mitochondrial deregulation in neutrophils perturbs immunological balance in type 2 diabetic conditions. By virtue of our data, we posit that maneuvering mitochondrial function might offer a prospective and viable method to modulate neutrophil function in T2DM. Nevertheless, similar investigations from other ethnic groups in conjunction with experimental evidences would be a preeminent need. Obviously, our study might aid to comprehend this complex interplay between mitochondrial dysfunction and neutrophil homeostasis in T2DM. 相似文献
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The immune system protects our bodies against infections and cancers. This review introduce readers to the thymus – a primary lymphoid organ – which is the site of development and maturation of functional T lymphocytes. Progenitor stem cells arise from the bone marrow and undergo sequential development in the thymus where non-self-reactive T cells are selected. Subsequently, post selection and maturation, the mature T cells exit the thymus as naïve T cells into the peripheral lymph nodes. Studies on the thymus are likely to enhance our understanding of T cell development and reduce disease burdens by improving the cellular immune response. 相似文献
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