Interaction of LDL and platelets in ischaemic and ischaemic risk subjects     

Yashika Gupta  V. Mallika  D. K. Srivastava 《Indian journal of clinical biochemistry : IJCB》2005,20(1):87-94

Platelets play a vital role in the progression of atherosclerosis and thrombosis, a major cause of death worldwide. Platelets are activated by many triggers like elevated LDL in blood resulting in aggregation and formation of plaque. The purpose of this study was to investigate the effect of LDL and signal transduction inhibitor on the activation of platelets in Ischaemic risk subjects. Platelets from IHD and hyperlipidemic subjects were hypersensitive to ADP, as higher levels of platelet aggregation were observed in these groups. LDL from IHD hyperlipidemic subjects was more effective in activating platelets from any other group. Ox-LDL was more effective in activating platelets than native-LDL as monitored by level of platelet aggregation induced by PAF and thrombin. Calcium channel blocker, nifedipine and verapamil inhibited platelet aggregation at micromolar level. Protein kinase inhibitor, staurosporine was effective in inhibiting ADP induced aggregation at nanomolar level.  相似文献   

Application of Sigma Metrics for the Assessment of Quality Assurance in Clinical Biochemistry Laboratory in India: A Pilot Study     

Singh B  Goswami B  Gupta VK  Chawla R  Mallika V 《Indian journal of clinical biochemistry : IJCB》2011,26(2):131-135

Ensuring quality of laboratory services is the need of the hour in the field of health care. Keeping in mind the revolution ushered by six sigma concept in corporate world, health care sector may reap the benefits of the same. Six sigma provides a general methodology to describe performance on sigma scale. We aimed to gauge our laboratory performance by sigma metrics. Internal quality control (QC) data was analyzed retrospectively over a period of 6 months from July 2009 to December 2009. Laboratory mean, standard deviation and coefficient of variation were calculated for all the parameters. Sigma was calculated for both the levels of internal QC. Satisfactory sigma values (>6) were elicited for creatinine, triglycerides, SGOT, CPK-Total and Amylase. Blood urea performed poorly on the sigma scale with sigma <3. The findings of our exercise emphasize the need for detailed evaluation and adoption of ameliorative measures in order to effectuate six sigma standards for all the analytical processes.  相似文献   

Serum and urinary zinc in zinc miners and zinc smelters     

P. P. Singh  K. H. Komleh  A. K. Pendse  Rajkiran  R. C. Gupta 《Indian journal of clinical biochemistry : IJCB》1992,7(1):57-59

Serum (200.6±64.8 mg/dl) and urinary zinc (1186.0±265.5 mg/l.) of zinc miners at Zawar were significantly higher as compared to zinc smelter workers (Serum 89.7±9.9. mg/dl; Urine 590.0±32.1 mg/l.). Debari and Udaipur residents (Serum 104.0±18.6 mg/dl; Urine 735.0±180.2 mg/l.). This was most likely attributable to higher dietary zinc intake by zinc miners due to higher zinc content of foodstuffs grown in Zawar areas as compared to Debari and Udaipur.  相似文献   

A Survey of Educational Psychologists’ Views on the Delivery of Behaviour Modification     

P. Coxhead  R. M. Gupta 《Educational studies》1989,15(1):15-22

The survey reported here was principally aimed at exploring the views of practising educational psychologists in the United Kingdom as to their implementation of behaviour modification. Approximately 10‐15 questionnaires were sent to each of 22 Psychological Services randomly selected from the Directory of School Psychological Services and Child Guidance Services. Seventy‐eight questionnaires (nearly 31% of those sent out) were received in time for their contents to be analysed. Two findings of the present survey are that an overwhelming majority of practising educational psychologists do not recommend behaviour modification in its traditional form, and that few educational psychologists believe that traditional behaviour modification can or should be implemented without any adaptation. An interesting, and somewhat unexpected finding, is that a vast majority of the respondents hold somewhat ‘and’ attitudes towards the traditional form of behaviour modification, although more experienced educational psychologists are somewhat less antagonistic.  相似文献   

Protein nanotechnology — A powerful futuristic diagnostic technique     

P. D. Gupta  Manasi Dave  A. R. Vasavada 《Indian journal of clinical biochemistry : IJCB》2005,20(2):48-53

Healthcare can be maintained well, when diagnosis is quick, accurate, cost-effective and painless. DNA and RNA based diagnosis may not reveal the right information for certain diseases. Identification and quantification of proteins and their folding mechanism are very important in diagnosis of diseases. Small quantities of proteins, which generally escape from detection and are responsible for the diseases, now can be quantified by protein nanotechniques which aids in the diagnosis. In this review, we have summarized the recent developments in nanotechnologies such as protein microarrays, biosensors etc. and their application in diagnosis of diseases at proteomics level have also been discussed.  相似文献   

晚期折返过程含石墨流体包裹体及其意义：以印度两个不同地体为例     

M.K.Panigrahi S.Gupta 《中国科技期刊研究》2007,23(1):53-64

  相似文献   

Young children's causal inferences   总被引：1，自引：0，他引：1  

P Das Gupta  P E Bryant 《Child development》1989,60(5):1138-1146

We report 2 experiments that show a striking development between the ages of 3 and 4 years in children's ability to make causal inferences about sequences of events. The task in the first experiment was to work out what had caused the change to an object that started out as odd (noncanonical) in 1 way and ended up as odd in 2 ways--starting, for example, as a broken cup and ending as a wet and broken cup. When asked to choose the instrument that had caused the change, 3-year-olds often selected the instrument that could have caused the initial state (a hammer, in our example) and not the instrument that would produce the change. 4-year-olds hardly ever made this mistake. In the second experiment, the 3-year-olds were able to make the correct choice when the change was from a canonical to a noncanonical state (cup-wet cup) but had much more difficulty when the change was from noncanonical to canonical (wet cup-dry cup). The difference was much smaller in the older group. The first of these tasks can be solved simply on the basis of knowledge that a particular instrument can cause a particular effect without reference to the initial state. The second task requires attention to the differences between initial and final state. We conclude that the ability to make genuine causal inferences develops between the ages of 3 and 4 years.  相似文献   

Innovations in science education: infusing social emotional principles into early STEM learning     

Pamela W. Garner  Nuria Gabitova  Anuradha Gupta  Thomas Wood 《Cultural Studies of Science Education》2018,13(4):889-903

We report on the development of an after-school and summer-based science, technology, engineering, and mathematics curriculum infused with the arts and social emotional learning content (STEAM SEL). Its design was motivated by theory and research that suggest that STEM education is well-suited for teaching empathy and other emotion-related skills. In this paper, we describe the activities associated with the development and design of the program and the curriculum. We provide expert-ratings of the STEAM and social emotional elements of the program and present instructor and participant feedback about the program’s content and its delivery. Our results revealed that infusing the arts and social emotional learning content into science education created a holistic STEM-related curriculum that holds potential for enhancing young children’s interest in and appreciation for science and its applications. The data also suggested that the program was well-developed and, generally well-executed. However, experts rated the STEAM elements of the program more positively than the SEL elements, especially with regard to sequencing of lessons and integration among the lessons and hands-on activities, indicating that program revisions are warranted.  相似文献   

Diagnostic and prognostic value of the urinary excretion of beta-aminoisobutyric acid in patients with urinary bladder cancer     

R. L. Gupta  K. Ramachandran  Monika  J. S. Chowhan 《Indian journal of clinical biochemistry : IJCB》1996,11(1):59-61

Urinary excretion of beta-aminoisobutyric acid (BAIB), was determined in 28 active and 12 inactive bladder cancer patients. Mean excretion of BAIB was higher in active cancer patients-187.8 mg/24 hours whereas it was 120.4 mg/24 hours in inactive cancer patients. The increased BAIB excretion in both disease groups was independent of tumour stage. BAIB appears to be a useful diagnositic aid in the assessment of bladder cancer patients.  相似文献   

Are we using Thyroid Function Tests Appropriately?     

Gupta S  Verma M  Gupta AK  Kaur A  Kaur V  Singh K 《Indian journal of clinical biochemistry : IJCB》2011,26(2):178-181

Thyroid function tests are very important for the diagnosis and monitoring of patients with thyroid dysfunction. The guidelines recommend serum thyroid stimulating hormone (TSH) as the single most reliable test to diagnose all common forms of hypothyroidism and hyperthyroidism. The aim of this study was to analyze the ordering pattern for thyroid function tests by physicians and the analysis of results based on the clinical history. The mean age of the patients was 32.5 ± 6.5 years. Majority of samples (87.7% of total) were received from the departments of Medicine and Gynae. Thyroid profiles (47.5%) were ordered more frequently as compared to TSH only (46%). There was no significant difference in the percentage of normal reports for both types of tests. 77.8% of TFT and 76.6% of TSH samples had results within the reference range. The percentage of abnormal results was 13.7% in the patients who were screened for thyroid disorders. There is a need to redefine the case definition for thyroid dysfunction and order the appropriate test in a rational and cost effective manner.  相似文献