Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

Engendering a culture of thinking in a culture of performativity: the challenge of mediating tensions in the Singaporean educational system     

Mohammad Akshir Ab Kadir 《Cambridge Journal of Education》2017,47(2):227-246

Among the major policies that have been implemented to ensure its continued success, Thinking Schools, Learning Nation (TSLN) has been described as the ‘big bang of educational reforms’ in Singapore. However, while the policy aims to develop critical thinkers in school leavers, the corporatisation of education in the shape of structures such as the school excellence model seems to be at odds with TSLN. This paper argues that these structures unwittingly engender a culture of performativity among schools, marginalising the central outcome of its initiative that entails developing a culture of thinking and thinkers. The tension is further exacerbated by the larger rationalities that have shaped Singapore and the pragmatic and instrumental philosophy which underpins its educational system. The tensions generated by the clash between intended (culture of thinking) and engendered culture (culture of performativity) present the challenge of mediation for the system on its path to realising TSLN.  相似文献   

Exploring and evaluating differentiated assessment practices of in-service teachers for components of differentiation     

Amrita Kaur  Mohammad Noman  Rosna Awang-Hashim 《Teaching Education》2019,30(2):160-176

Classroom assessment is central to effective teaching and learning, making assessment literacy a core component for teacher education. The present study explores self-reported, differentiated assessment practices of Malaysian in-service teachers. The practices were evaluated using an analytic framework that was developed based upon the existing literature on components of differentiation. Data were collected from 32 in-service teachers using open-ended survey questionnaires. Twelve of the teachers also participated in in-depth interviews. Documents provided by the teachers were also analyzed. Data from the open-ended survey were analyzed using NVivo11 to develop codes for the analytic framework. The findings offer insights into teachers’ knowledge, application, and interpretation of differentiated assessment practices. The discussion explores teachers’ explanations of their own practices and, further, recommends ways to improve knowledge and application of differentiated assessment. The implications of the findings are discussed for assessment literacy-related professional development for teachers, school management and policies to facilitate implementation of differentiated assessment.  相似文献   

Structuring collaboration in mixed-ability groups to promote verbal interaction,learning, and motivation of average-ability students     

Mohammad Saleh  Ard W. LazonderTon de Jong 《Contemporary educational psychology》2007

Average-ability students often do not take full advantage of learning in mixed-ability groups because they hardly engage in the group interaction. This study examined whether structuring collaboration by group roles and ground rules for helping behavior might help overcome this participatory inequality. In a plant biology course, heterogeneously grouped fourth-grade boys (n=164) were randomly assigned to a structured collaboration condition or an unconstrained comparison condition. Results indicated positive effects of structured collaboration on average-ability students’ achievement, motivation, and contribution to the group interaction. Another positive result was that structuring collaboration did not lower the scores of the high and low-ability students on these measures.  相似文献   

Thyroid hormones status during pregnancy in normal Iranian women     

Nosratollah Zarghami  Mohammad Rohbani-Noubar  Ali Khosrowbeygi 《Indian journal of clinical biochemistry : IJCB》2005,20(2):182-185

Pregnancy is associated with significant, but reversible changes in thyroid function studies, which are among the most profound seen as a result of a normal physiologic state. The present study was carried out to find out alterations in thyroid function tests in each trimester in normal pregnant women as compared to non-pregnant women in Tabriz-Iran. A case-control study designed with 229 normal pregnant women that randomly selected from the first (64 samples), the second (92 samples), and the third (73 samples) trimesters and 250 randomly selected non-pregnant healthy female controls. Age range in both groups was 16–40 years. Thyroid function tests carried out by measuring serum levels of thyroid stimulating hormone (TSH), free and total thyroxin (FT₄, TT₄), and free and total triiodothyronine (FT₃, TT₃) by commercially available radio immunoassay kits. We found that mean TT₄ increased progressively during pregnancy. Our study showed increasing in serum levels of TT₃ in the second trimester and then declining during the third trimester compared with non-pregnant women. We showed that FT₄ strongly decreased during the third trimester. Free T₃ showed declining in the second and third trimesters. Mean TSH did not show significant difference in each trimester compared with non-pregnant women. The thyroid function tests in pregnancy should be interpreted against gestational age-related reference intervals to avoid mis-interpretation of thyroid function during pregnancy.  相似文献   

H∞ dynamic observer-based fuzzy integral sliding mode control with input magnitude and rate constraints     

Zeinab Echreshavi  Mokhtar Shasadeghi  Mohammad Hassan Asemani 《Journal of The Franklin Institute》2021,358(1):575-605

This paper focuses on a systematic constrained fuzzy integral sliding mode controller design for a class of uncertain discrete-time nonlinear systems which can be represented as Takagi-Sugeno (T-S) fuzzy models. The contributions are to consider constraints on the control input amplitude and control input amplitude rate and to extend the existing pole-placement design technique for designing gain matrices of the fuzzy sliding surface. Moreover, a dynamic-gain observer along with ${\mathit{H}}_{\infty }$ performance is proposed for attenuating disturbance, which generalizes the existing results on the Proportional Observer (PO), the Proportional Integral Observer (PIO) and the dynamic observer (DO). Finally, the dynamic-observer-based constrained fuzzy integral sliding mode controller is designed. All the proposed design conditions are represented in terms of LMIs-based ones. The methods are studied for not only single-input single-output (SISO) but also multi-input multi-output (MIMO) systems. In the end, the proposed approaches are evaluated on practical and numerical systems to illustrate the superiority of the proposed control scheme.  相似文献   

How online career counseling changes career development: A life design paradigm     

Nooshin Pordelan  Ahmad Sadeghi  Mohammad Reza Abedi  Marjan Kaedi 《Education and Information Technologies》2018,23(6):2655-2672

  相似文献   

On the relationship between gender and perceptual language learning styles: the case of Iranian academic EFL learners     

Mohammad Aliakbari  Khalil Tazik 《教育心理学》2011,31(6):657-674

  相似文献   

Should Gender Differences be Considered When Assessing Student Satisfaction in the Online Learning Environment for Millennials?          下载免费PDF全文

Heather Lea Harvey  Sanjai Parahoo  Mohammad Santally 《Higher Education Quarterly》2017,71(2):141-158

The majority of today's students in online higher education are millennials and have grown up using technology. Therefore, there is a need to determine if their expectations from online learning are different from previous contextual studies and whether or not these vary across gender. This study used a mixed method approach, using focus groups, followed by online surveys of 834 undergraduate students from the University of Mauritius enrolled in an online course. Using factor analysis and structural equation modelling, the study found no significant differences based on gender for millennials, but identified three significant antecedents of student satisfaction for both males and females: university reputation; physical facilities; and instructor empathy.  相似文献   

Hasse,Cathrine (2015) An anthropology of learning. Springer (Berlin) isbn 978‐94‐017‐9605‐7 320 pp £90 (ebook £72) http://www.springer.com/us/book/9789401796057#          下载免费PDF全文

Mohammad Ali Salmani Nodoushan 《British journal of educational technology : journal of the Council for Educational Technology》2015,46(6):E30-E31

This book combines cultural models with practice‐based learning to develop a new theory of cultural learning. Drawing on insights from anthropology, it argues how collective and social cultures can emerge from an “engaged” learning process. The book opens a new window on human learning; however, you will probably find only parts of it of some interest or use. Mohammad Ali Salmani Nodoushan  相似文献