Membrane-integrated microfluidic device for high-resolution live cell imaging     

Epshteyn AA  Maher S  Taylor AJ  Holton AB  Borenstein JT  Cuiffi JD 《Biomicrofluidics》2011,5(4):46501-465016

The design and fabrication of a membrane-integrated microfluidic cell culture device (five layers,≤500 μm total thickness) developed for high resolution microscopy is reported here. The multi-layer device was constructed to enable membrane separated cell culture for tissue mimetic in vitro model applications and pharmacodynamic evaluation studies. The microdevice was developed via a unique combination of low profile fluidic interconnect design, substrate transfer methodology, and wet silane bonding. To demonstrate the unique high resolution imaging capability of this device, we used oil immersion microscopy to image stained nuclei and mitochondria in primary hepatocytes adhered to the incorporated membrane  相似文献   

Face-to-face contact in blended learning for intercultural education: the role of teachers     

Roger Austin  Angela Rickard  Jacqueline Reilly 《Irish Educational Studies》2017,36(3):323-340

In societies experiencing or emerging from conflict, teachers often deliver educational programmes designed to build community cohesion. We report on research which examined teachers’ views of the implementation of a programme involving both face-to-face and online contact between pupils. Findings suggest that this blended approach is highly motivational, enhancing online work and relationship building. The research underlines the importance of the political, educational and historical context for work of this sort and the impact this has on the particular blend of online and face-to-face interaction. Implications for policymakers and teachers include value for money and sustainability of blended intercultural education in similar contexts.  相似文献   

Recruiting older adults as participants in applied social research: Applying and evaluating approaches from clinical studies     

Joyce Weil  Angela Nancy Mendoza  Erin McGavin 《Educational gerontology》2017,43(12):662-673

While issues of recruiting older persons in clinical trials are well known, efficacious strategies in the recruitment process in applied social research are less explored. As more research becomes community-based, it is useful to see, if effective clinical-trial recruitment strategies can be applied to social and applied research studies. The goal of this article is to examine clinical recruitment strategies used with older adults (e.g. print and electronic advertising, referrals, and community-partnered approaches) in applied social research studies and to illustrate issues arising from the use of each recruitment approach with older adults in real-life settings. Experiences from four community-based, social research studies are included to show how some of the most successful clinical recruitment strategies fare in social gerontological studies. Specific guidelines are provided about how recruitment strategies can aid in future study planning and improved recruitment of older participants in social research.  相似文献   

‘It's more flexible’: persistence of women engineers in the academy     

Yeukai Angela Mlambo  Reitumetse Obakeng Mabokela 《European Journal of Engineering Education》2017,42(3):271-285

The under-representation of women in engineering is an issue of concern for policy-makers. While much of the existing literature has focussed on understanding reasons for women's under-representation in engineering and related technical fields, there is a paucity of research that examines why women who are already in engineering persist. This study aims to answer the question, why do women engineers in academe persist in a discipline that is generally perceived to be inhospitable to women. Three main challenges, namely gender discrimination, lack of institutional and disciplinary support, and the rigid nature of the workplace, emerged as key impediments to women engineers in the private sector. In contrast, women engineers in the academy identified the flexibility offered by academic environments, the presence of personal support networks, and a passion for teaching and students as critical factors that influenced their decision to remain in academia.  相似文献   

Creating a learner-centered teaching environment using student choice in assignments     

Cheryl Hanewicz  Angela Platt  Anne Arendt 《Distance Education》2017,38(3):273-287

Learner-centered teaching (LCT) has been found to be a more effective pedagogy for online students, as traditional teaching methods do not work well in online courses. Professors in an upper-level technology management class revised their online introductory course to incorporate cafeteria-style grading. This LCT approach allowed students to select assignments they wanted to complete. More assignments were offered than needed to achieve an A grade. They included traditional projects such as research papers as well as more engaged activities such as demonstrating or mastering skills. To determine whether these changes promoted active learning, course data were obtained and analyzed. Students completed a range of assignments, showed mastery on a number of skills, and were overwhelmingly positive about having flexible options. Tellingly, 36% of students completed more assignments than were needed to earn the top grade.  相似文献   

Advanced,Analytic, Automated (AAA) Measurement of Engagement During Learning     

Sidney D'Mello  Ed Dieterle  Angela Duckworth 《教育心理学家》2017,52(2):104-123

It is generally acknowledged that engagement plays a critical role in learning. Unfortunately, the study of engagement has been stymied by a lack of valid and efficient measures. We introduce the advanced, analytic, and automated (AAA) approach to measure engagement at fine-grained temporal resolutions. The AAA measurement approach is grounded in embodied theories of cognition and affect, which advocate a close coupling between thought and action. It uses machine-learned computational models to automatically infer mental states associated with engagement (e.g., interest, flow) from machine-readable behavioral and physiological signals (e.g., facial expressions, eye tracking, click-stream data) and from aspects of the environmental context. We present 15 case studies that illustrate the potential of the AAA approach for measuring ensgagement in digital learning environments. We discuss strengths and weaknesses of the AAA approach, concluding that it has significant promise to catalyze engagement research.  相似文献   

The disposition of concern: an exploration into the affects of the power-knowledge dynamics uncovered during research into pupils’ perceptions of terrorism     

Angela Quartermaine 《International Journal of Research & Method in Education》2017,40(5):541-553

In recent years, counter-terrorism measures have become incorporated into the UK education system, with the latest 2015 Counter-Terrorism and Security Act expanding on previous government policy by making it mandatory for schools to be actively involved with counter-terrorism measures [Clause 21, H.M. Government 2015. Counter-Terrorism and Security Act. London: Crown Copyright, 18]. However, during my research into pupils’ perceptions of terrorism, I discovered that conducting such discussions within the classroom setting were restricted from the outset. These findings are useful in demonstrating the difficulties facing those expected to deliver government policy and highlight how education researchers (and teachers) need to be aware of certain considerations prior to engaging in such sensitive subject matter with young people. This article provides an overview of my findings in this regard and demonstrates the complexities associated with discussing the topic of terrorism, in particular it’s relationship with religion, within schools. By using Foucault’s philosophical insights into power-knowledge [[1975] 1991. Discipline and Punish: The Birth of the Prison. London: Penguin] to analyse this data, I discovered a common trait, which I categorized as ‘the disposition of concern’, that affected and restricted the scope of such discussions.  相似文献   

A Prospective Study of Life Stress, Social Support, and Adaptation in Early Adolescence   总被引：9，自引：0，他引：9  

David L. DuBois  Robert D. Felner  Stephen Brand  Angela M. Adan  Elizabeth G. Evans 《Child development》1992,63(3):542-557

This study employed a 2-year longitudinal design to examine the relation of stressful life events and social supports to psychological distress and school performance among 166 early adolescents (mean age = 13.5 years). A prospective approach was utilized to control for initial levels of adjustment when examining the relation of Time 1 stress and support variables to Time 2 psychological distress and school performance. Both stress and support variables made significant contributions to the prediction of subsequent psychological distress. Stresses, but not supports, made a significant contribution to the prediction of subsequent school performance. Evidence for reciprocal and interactive linkages was also found, including effects of psychological distress and school performance on subsequent stresses and supports, and greater adaptive impact of school-based supportive resources under conditions of heightened risk outside of school. Implications for ecological and transactional models of development relating to the targeting and efficacy of preventive efforts are discussed.  相似文献   

Multigrade teaching: towards an international research and policy agenda   总被引：2，自引：0，他引：2  

Angela W. Little   《International Journal of Educational Development》2001,21(6):121

Despite its prevalence in many educational systems, multigrade teaching remains invisible. In the global effort to achieve education for all in the post-Dakar decade the needs of multigrade teachers, classes and schools must be addressed. The paper (i) explores the meaning of the term multigrade teaching in developing and industrialised countries and identifies a range of conditions under which it arises; (ii) synthesises knowledge of the practice of and research on multigrade teaching; and (iii) proposes an international agenda for future research on and dissemination of policy and practice. The agenda underlines the need for context-specific questions and comparisons, more awareness of the prevalence and challenges of multigrade teaching, more research on the practices and training needs of multigrade teaching and the exploration of synergies between teachers, curriculum, assessment and classroom organisation. It is suggested that knowledge of multigrade teaching strategies is needed by all teachers and not simply those in classes designated as ‘multigrade’.  相似文献   

Teaching and Research: New relationships and their implications for inquiry-based teaching and learning in higher education     

Angela Brew 《高等教育研究与发展》2003,22(1):3-18

In order to bring teaching and research together, a fuller understanding of how academics conceptualise research and scholarship is needed. The paper discusses different ways in which research and scholarship are conceptualised and then provides two alternative models of the relationship between teaching and research based on different conceptions of teaching and different ideas about the nature of knowledge. The paper suggests that if the relationship between teaching and research is to be enhanced it is necessary to move towards a model based on the notion of academic communities of practice. The implications for higher education of doing this are then examined. It is argued that there is a need to reconceptualise the role of higher education and to renegotiate relationships between teachers and students.  相似文献