Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

Validity and reliability of a linear positional transducer across commonly practised resistance training exercises     

Harry F. Dorrell  Joseph M. Moore  Mark F. Smith  Thomas I. Gee 《Journal of sports sciences》2019,37(1):67-73

This study investigated the validity and reliability of the GymAware PowerTool (GPT). Thirteen resistance trained participants completed three visits, consisting of three repetitions of free-weight back squat, bench press, deadlift (80% one repetition maximum), and countermovement jump. Bar displacement, peak and mean velocity, peak and mean force, and jump height were calculated using the GPT, a three-dimensional motion capture system (Motion Analysis Corporation; 150 Hz), and a force plate (Kistler; 1500 Hz). Least products regression were used to compare agreeability between devices. A within-trial one-way ANOVA, typical error (TE; %), and smallest worthwhile change (SWC) were used to assess reliability. Regression analysis resulted in R² values of >0.85 for all variables excluding deadlift mean velocity (R² = 0.54–0.69). Significant differences were observed between visits 3-2 for bench press bar displacement (0.395 ± 0.055 m; 0.383 ± 0.053 m), and deadlift bar displacement (0.557 ± 0.034 m; 0.568 ± 0.034 m). No other significant differences were found. Low to moderate TE (0.6–8.8%) were found for all variables, with SWC ranging 1.7–7.4%. The data provides evidence that the GPT can be used to measure kinetic and kinematic outputs, however, care should be taken when monitoring deadlift performance.  相似文献   

The Clarke County (Alabama) War Memorial: Kairos and Chronos United in the Sacred Commemoration and Contemplation of Five Wars     

Alison I. English 《Journal of American culture (Malden, Mass. : 2003)》2004,27(4):384-405

  相似文献   

Themenheft: Datenintegration     

Theo H?rder 《Informatik - Forschung und Entwicklung》2002,17(3):99-100

Ohne Zusammenfassung  相似文献   

REAL: Ein ressourcenadaptierendes mobiles Navigationssystem     

Wolfgang Wahlster  J?rg Baus  Christian Kray und Antonio Krüger 《Informatik - Forschung und Entwicklung》2001,16(4):233-241

Zusammenfassung.   Die intelligente Ressourcenadaption ist eine der gro?en Herausforderungen für die n?chste Generation mobiler Navigationssysteme. Da man typischerweise mehrere Fortbewegungsarten oder Verkehrsmittel kombinieren muss, um an einen Zielort zu gelangen, muss sichergestellt werden, dass mobile, allgegenw?rtige Navigationshilfen dies über eine jeweils situationsangepasste Benutzerschnittstelle unterstützen. Der notwendige Wechsel zwischen verschiedenen Positionierungstechnologien soll für den Endbenutzer m?glichst unbemerkt bleiben. Im folgenden wird ein hybrides Personennavigationssystem vorgestellt, das die in bestimmten Fortbewegungssituationen verfügbaren Positionierungstechnologien und deren Genauigkeit optimal nutzt, um die Pr?sentation der Wegbeschreibung auf verschiedene Endger?te und Ausgabemodalit?ten sowie die kognitive Ressourcenlage des Benutzers zu adaptieren. Eingegangen am 28. Februar 2001 / Angenommen am 8. August 2001  相似文献   

教练员与运动员关系的研究   总被引：7，自引：0，他引：7  

程云峰  姜丽  杨太胜  王阜存  李金珠  张晓蓬 《山西师大体育学院学报》2002,17(2):51-53

我国竞技体育,教练员与运动员关系好的不乏其人,他们努力训练,通力合作,为我国的竞技体育的腾飞作出了卓越的贡献,但也有些教练员与运动员关系不融洽,使运动员过早地离开运动场,失去了为国争光的机会。文章通过教练员和运动员关系的研究,旨在为提高竞技运动水平和教练员在选材、训练时提供参考。  相似文献   

健康——不可忽视的人力资本投资     

傅玲  白文飞 《首都体育学院学报》2002,14(3):27-28

健康作为一种人力资本投资对提高生产力、促进经济发展和个人发展有着重要的作用。它可以提高劳动者的生产效率，刺激教育方面的投资，使人具有更多的时间和能力利用其他资本要素，具有更大的财力（因减少医疗费用）用于其他方面的投资。所以进行人力资本投资时，不可忽视健康这一要素，它也是人力资本形成的重要途径，也对经济增长起着有力的推动作用。  相似文献   

    

Florence Chang  Marco A. Mu?oz 《Journal of Personnel Evaluation in Education》2006,19(1-2):35-49

There is an increasing interest in linking character education programs with social and academic outcomes. The Child Development Project (CDP) is a character education program that promotes academic and social growth in teachers and students. This theory-driven evaluation employed a quasi-experimental design with matched control schools. School personnel participated in an intensive professional development process to learn the CDP model. Performance measures included state-mandated achievement measures, teacher self-assessment reports, and student attitudes and outcomes. Results yielded support for the CDP model as a strategy to improve social and, if properly implemented, cognitive outcomes in students; the model also improved teacher self-assessment and provided information that may facilitate professional growth about school collegiality. Implications for policy and practice will be discussed.  相似文献   

计算机和校园网在高校基层田径比赛中的应用     

林东  施芳芳  李锦标 《浙江体育科学》2001,23(5):22-25

运用计算机和校园网对高校基层田径比赛进行管理和操作，具有安全，方便，快捷的特点，可以提高裁判员和工作人员的工作效率，并确保比赛数据统计的准确性，为今后高校基层田径比赛组织和裁判工作的改革提供他一种科学，高效，实用的方法。  相似文献   

试论高职学院体育师资队伍建设   总被引：2，自引：0，他引：2  

向亦明 《浙江体育科学》2001,23(1):31-33

随着社会和高等教育形势的快速发展，高等职业技术教育成为高等教育的一部分，已成为当前社会关注的一个热点。高职学院要能适应高等教育的要求，适应新的办学模式，全面提高教学质量和办学水平，关键是拥有一支与人才培养目标相一致的数量、质量合格的教师队伍。而目前高职学院体育师资队伍的现状，与高等教育的要求及全面推进学校体育工作深化改革的目标，尚存有较大的差距。因此要针对现状，在加强教师政治思想、德育教育，优化教师知识结构，优化师资队伍结构，提高教学科研能力、水平等几个主要方面，采取积极有效的措施；加强队伍建设，全面提高体育教师的整体素质水平，尽快适应高等教育发展的需要及高校体育教学改革、科学研究的要求。  相似文献