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While literature reviews with a large-scale scope are nowadays becoming a staple element of modern research practice, there are many challenges in taking on such an endeavour, yet little evidence of previous studies addressing these challenges exists. This paper introduces a practical and efficient review framework for extremely large corpora of literature, refined by five parallel implementations within a multi-disciplinary project aiming to map out the research and practice landscape of modelling, simulation, and management methods, spanning a variety of sectors of application where such methods have made a significant impact. Centred on searching and screening techniques along with the use of some emerging IT-assisted analytic and visualisation tools, the proposed framework consists of four key methodological elements to deal with the scale of the reviews, namely: (a) an incremental and iterative review structure, (b) a 3-stage screening phase including filtering, sampling and sifting, (c) use of visualisation tools, and (d) reference chasing (both forward and backward). Five parallel implementations of systematically conducted literature search and screening yielded a total initial search result of 146 087 papers, ultimately narrowed down to a final set of 1383 papers which was manageable within the limited time and other constraints of this research work.  相似文献   
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Taxonomy of e-readiness assessment measures   总被引:1,自引:0,他引:1  
To benefit from the advantages of information society, on the one hand, and to be afraid of being left further behind by Global Society and the increase in the digital divide, on the other hand, stimulate countries to be part of Global Information Society. These issues have led policymakers to move towards such a society by identifying the objectives, goals and targets. Planning to achieve these objectives needs a real understanding of the current situation, which is obtained by e-readiness assessment measures. There has been a proliferation of e-readiness assessment measures in recent years that each one has a certain objective. This paper elaborates on and categorizes these measures that help scholars and policymakers to (1) select the measures that fit in with their objectives, (2) prevent the repetitive research, (3) identify the defects and flaws of previous measures and correct them in their own measures, and (4) use the experiences of previous measures to construct their own ones. Based on definitions, objectives, dimensions, methods and approaches, in this paper, the measures are categorized and finally, a measure for e-readiness assessment is presented. Since this measure is a convergence of e-readiness assessment measures, the experienced modelers have consensus on it and it is more suitable to measure e-readiness of countries. Also, it can be exploited as the basis and standard for internationally comparable information society statistics.  相似文献   
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The purpose of this study was to determine the rate and type of injury in elite Canadian Taekwondo athletes, before and during competition and to investigate the relationship between past injuries, injuries during competition and success. This retrospective case-series study incorporated Taekwondo injuries sustained by 75 male and female elite Canadian Taekwondo athletes over 10 years and its relationship to athletes' success by means of gaining medals during competition. A logistic regression model (using the Generalised Estimating Equations (GEE) method) was used to investigate the relationship between injuries and success. Injury rate was associated with performance after holding variables constant (Odds Ratio (OR) = 0.124, P = 0.039). Moreover, with each additional injury per match, competitors were 88% (1-0.124) less likely to win a medal. Although not statistically significant, additional injuries prior to competition were associated with a 30% increase in medal prevalence (OR = 1.299, P = 0.203). When comparing athletes (gender, tournament difficulty, injury variables), a competitor who is one year older is 10% less likely to medal (OR = 0.897, P = 0.068). When an additional injury occurred during competition, the athlete was 88% less likely to win a medal. Prevention, correct diagnosis, and immediate therapeutic intervention by qualified health care providers are important.  相似文献   
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Higher Education - About one-third of college students drop out before finishing their degree. The majority of those remaining will take longer than 4 years to complete their degree at...  相似文献   
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Education and Information Technologies - The COVID-19 crisis has had a profound effect on higher education, especially medical education due to its sensitive nature, dealing with people’s...  相似文献   
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In the present study, paclitaxel was archaeosomed to reduce side effects and improve its therapeutic index. Carriers have made a big evolution in treatment of many diseases in recent years. Lipid carriers are of special importance among carriers. Archaeosome is one of the lipid carriers. Paclitaxel is one of the drugs used to treat breast cancer which has some unwanted side effects despite its therapeutic effects. Archaeosomes were extracted from methanogenic archi bacteria and synthesized with a certain ratio of paclitaxel in PBS. The mean diameter of archaeosomal paclitaxel was measured by Zeta sizer instrument, Drug releasing of archaeosomal paclitaxel was examined within 26 h which results showed that the most drug releasing occurs during first 3 h. The cytotoxicity effect of archaeosomal paclitaxel on breast cancer’s cell line was evaluated by MTT assay which results showed that the cytotoxicity effect of archaeosomal paclitaxel on breast cancer’s cell line is more than that of the standard paclitaxel formulation. The results indicated that new drug delivery of paclitaxel using archaeosome, increases the therapeutic index of the drug.  相似文献   
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The objective of this study is to induce experimental diabetes mellitus by streptozotocin in normal adult Wistar rats via comparison of changes in body weight, consumption of food, volume of water, urine and levels of glucose, insulin and C-peptide in serum, between normal and diabetic rats. Intra-venous injection of 60 mg/kg dose of streptozotocin in 250–300 g (75–90 days) adult Wistar rats makes pancreas swell and causes degeneration in Langerhans islet β-cells and induces experimental diabetes mellitus in 2–4 days. For a microscopic study of degeneration of Langerhans islet β-cells of diabetic rats, biopsy from pancreas tissue of diabetic and normal rats, staining and comparison between them, were done. In this process, after collagenase digestion of pancreas, islets were isolated, dissociated and identified by dithizone method and then with enzymatic procedure by DNase and trypsin, the islet cells changed into single cells and β-cells were identified by immune fluorescence method and then assayed by flow-cytometer. Donor tissue in each step of work was prepared from 38 adult male Wistar rats weighted 250–300 g (75–90 days). Transplantation was performed in rats after 2–4 weeks of diabetes induction. In this study, the levels of insulin, C-peptide and glucose in diabetic rats reached to normal range as compared to un-diabetic rats in 20 days after transplantation of islet cells. Transplantation was performed under the cortex of testis as immunoisolated place for islet cells transplantation.  相似文献   
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