Analysis of SEVA TB ES-31 antigen specific immunoglobulins IgM, IgA and IgG in sera of sputum and culture positive pulmonary tuberculosis     

Sonika Gupta  Niraj Shende  Swati Banerjee  Satish Kumar  M. V. R. Reddy  Bhaskar C. Harinath 《Indian journal of clinical biochemistry : IJCB》2002,17(1):5-8

Tuberculosis remains major health problem in India and developing countries Immunodiagnosis has important role in screening, diagnosis and management of tuberculosis. SEVA TB ES-31 antigen has shown potential in detecting tuberculous IgG antibody in earlier studies from our laboratory. In the present study we have analysedSEVA TB ES-31 antigen specific immunoglobulinsIgM, IgA and IgG in clinically and bacteriologically confirmed pulmonary tuberculosis cases to determine the usefulness of specific immunoglobulin class in the diagnosis of patients attending the hospital. Of the 30 cases of pulmonary tuberculosis 25 (83.3%) were positive for IgG, 19 (63.3%) for IgM and 16 (53.3%) for IgA. On combining IgG and IgM positivity, sensitivity was increased to 93.3%. While combining IgG and IgA positivity, sensitivity increased to 90%. However specificity was decreased to 66.6% and 70% for both of these combinations respectively. It could be envisaged from this study that IgG antibody detection against ES-31 antigen showed acceptable sensitivity (83.3%) and specificity (86.6%) compared to IgM or IgA alone or in combination. When immune responses were analysed according to degree of sputum positivity, IgG response was observed to be predominant in all grades, compared to IgM or IgA antibody. The addition of IgM or IgA as an adjunct test increases the sensitivity but at the cost of specificity. Hence the detection of IgG alone is more useful compared to IgM or IgA assay, in detecting tuberculosis disease cases coming to the hospital.  相似文献   

Method evaluation of an enzymatic method for serum creatinine     

K. S. S. Saibaba  P. V. L. N. Srinivasa Rao  K. V. Dakshina Murty  M. Vijaya Bhaskar 《Indian journal of clinical biochemistry : IJCB》1997,12(2):139-141

Selecting the correct method for routine analysis by ‘method evaluation’ is an important component of quality assurance. It is a step-wise procedure that evaluates various analytical parameters like accuracy, precision etc of the given method. Finally reference intervals are established for selected population. We evaluated an enzymatic method for serum creatinine. The results show that it is an acceptable method based on the above mentioned criteria.  相似文献   

Preface     

Bhaskar C. Harinath 《Indian journal of clinical biochemistry : IJCB》1997,12(1):2-2

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How to stay away from each other in a spherical universe     

Bhaskar Bagchi 《Resonance》1997,2(10):38-45

In the first part we discussed Tammes’ problem and its higher dimensional analogues. In this part we shall see how harmonic analysis and the theory of orthogonal polynomials can be used to settle some of the most interesting instances of this problem.  相似文献   

Efficient Degumming of Rice Bran Oil by Immobilized PLA1 from Thermomyces lanuginosus     

Tripti Singhania  Harsh Sinha  Paulomi Das  Amit Kumar Mukherjee 《Food Technology and Biotechnology》2015,53(1):91-95

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Diversity incorporated energy adaptation for A-CDMA systems over slow fading channels     

Vidhyacharan Bhaskar 《Journal of The Franklin Institute》2011,348(9):2503-2522

In this paper, a theoretical analysis of diversity incorporated Variable Energy Adaptation (VEA) in an Asynchronous Code Division Multiple Access (A-CDMA) system is discussed for Rayleigh, Rician and Nakagami slow fading channels. The adaptation is accomplished by providing the receiver with the capability of measuring the signal energy-to-noise ratio, and controlling the transmitted signal energy by means of a noise-free feedback loop. System parameters such as fading margin, maximum signal-to-noise ratio, and mean transmitter energy gain are derived and plotted for fading channels as a function of the probability of error specification and the probability of unsatisfactory operation. The mean and median probabilities of error are plotted as a function of energy-to-noise ratios for different fading channels. Error probability distribution and density functions are derived and plotted for various signal-fading distributions.  相似文献   

Science education for empowerment and social change: A case study of a teacher educator in urban Pakistan     

Rubina Zahur  Angela Calabrese Barton  Bhaskar Raj Upadhyay 《International Journal of Science Education》2013,35(9):899-917

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Molecule of the month     

R N Mukherjee 《Resonance》1996,1(4):58-60

A dinuclear copper (II) complex is a synthetic catalyst for modelling enzymatic cleavage of RNA  相似文献   

How to decide how to decide     

R. Bhaskar  John A. Herstein  John R. Hayes 《Instructional Science》1983,12(3):267-277

This article attempts to characterize the general problem of selecting methods for decision-making. The traditional rational approach to choice is from economics, which offers expected-value maximization. The task environment of decision method selection, however, does not seem to provide the data necessary for carrying out the expected-value calculations. Our approach uses methods from the field of cognitive science. We develop the notion of domain size in fields such as chess, borrowing the concept of a chunk from human memory. We then develop a heuristic rule for choiceamongmethods. We propose this rule as one of many possible rules.  相似文献   

A conceptual framework for comparing instructional design models     

Gerald S. Edmonds  Robert C. Branch  Prachee Mukherjee 《Educational technology research and development : ETR & D》1994,42(4):55-72

Instructional design (ID) professionals typically employ models that guide their practice. However, it is unclear how a specific model is selected for an instructional situation. Andrews and Goodson (1980) provided a valuable procedure for comparing instructional design models, but because of the proliferation of variations in instructional design applications during the past decade, the introduction of instructional design into new learning contexts and the emergence of alternative approaches to instructional design, there has emerged a need for a new framework which assesses the potential success of any instructional design model. A framework is presented here which is intended to provide a conceptual tool for determining appropriate instructional design applications.  相似文献