Editorial     

Jon C. Giullian 《Slavic & East European Information Resources》2020,21(1-2):1-4

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Inflammatory and apoptotic signalling pathways and concussion severity: a genetic association study     

Sarah Mc Fie  Shameemah Abrahams  Jon Patricios  Jason Suter  Michael Posthumus 《Journal of sports sciences》2018,36(19):2226-2234

The objective was to investigate the relationship between IL-1B rs16944, IL-6 rs1800795, and CASP8 rs3834129 genetic polymorphisms and concussion severity. Rugby players from high school, senior amateur, and professional teams completed a concussion severity questionnaire and donated a DNA sample. Participants (n = 163) were split into symptom severity groups around the median number and duration of symptoms. The frequency of participants with high symptom counts (more than five symptoms) increased across the IL-1B (C/C: 35%; C/T: 51%; T/T: 56%; P = 0.047) and the IL-6 (C/C: 31%; C/G: 44%; G/G: 58%; P = 0.027) genotypes. The C–C inferred interleukin allele construct frequency, created from combining the IL-1B and IL-6 genotype data, was lower in participants reporting a high symptom count (18%), compared to those with a low symptom count (fewer than six symptoms, 36%, P = 0.002). Similarly, the C–C inferred interleukin allele construct frequency was lower in those reporting prolonged symptom duration (more than one week, 16%), as opposed to short symptom duration (less than one week, 34%, P = 0.015). This study provides evidence of novel inflammatory pathway genetic associations with concussion severity, which supports the hypothesis implicating neuroinflammation in the development of concussion symptoms.  相似文献   

Old Wine in old Bottles: the Neglected Role of Vocational Training Centres in Innovation     

Igone Porto Gómez  Jon Mikel Zabala-Iturriagagoitia  Urko Aguirre Larrakoetxea 《Vocations and Learning》2018,11(2):205-221

Vocational training centres are conceptually regarded as key players in the knowledge generation and dissemination processes that take place within innovation systems. However, the literature does not provide conclusive evidence of their influence on the generation, development and dissemination of innovations. The goal of this paper is to analyse whether vocational training centres are indeed relevant agents in the articulation, knowledge exchange and dissemination of a local innovation system. The paper explores the most influential agents driving cooperation and articulating the local innovation system in Durango, one of the twenty counties of the Basque Country, Spain. Social network analysis is applied to regional collaboration networks in order to address this purpose. Our results show evidence of the pivotal role played by vocational training centres within local innovation processes implemented by firms. For many local firms vocational training centres represent the main sources of knowledge in their innovation processes. In the Basque context, vocational training centres have a longer history than other knowledge infrastructures, such as universities and research centres. These long-standing centres thus constitute ‘old bottles’ that despite their history are still able to produce a ‘good old wine’ in terms of innovation, which is translated into competitive advantage for the territory. Science, technology and innovation policies should therefore not only aim to create more knowledge infrastructures, but also to reinforce the role that traditional and territorially established organizations like vocational training centres can play as intermediary agents.  相似文献   

Why We Say it Like That: Making Rhetorical Practices Explicit for Students in Disciplinary and Interdisciplinary Courses     

Jon C. Wiebel 《College Teaching》2018,66(1):24-30

Students in colleges and universities need to be able to learn how to communicate effectively both within the specialized arenas of their chosen disciplines and, increasingly, with a wide variety of public and professional audiences. One way to accomplish this goal is to integrate the development of effective writing and speaking skills into both our disciplinary and interdisciplinary classrooms. In this essay, we suggest that faculty to adopt a “rhetorical perspective” in their teaching, regardless of discipline, in order to capitalize on already existing faculty expertise and empower students. Specifically, a rhetorical perspective integrating speaking and writing can help students to become more active agents in their intellectual development, can help faculty design assignments and activities that relate directly to course goals and learning outcomes, and can provide a framework for feedback that can facilitate student learning.  相似文献   

Becoming ourselves     

Jon Nixon 《Teaching in Higher Education》2018,23(7):902-907

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‘All of us together in a blurred space’: principles for co-creating curriculum with international partners     

Rebecca Bilous  Laura Hammersley  Kate Lloyd  Felicity Rawlings-Sanaei  Greg Downey  Maria Amigo 《International Journal for Academic Development》2018,23(3):165-178

This paper shares an innovative methodology to ‘co-create’ a curriculum with eleven international community development organisations from seven countries to prepare undergraduate students for international work-integrated learning activities. The co-creation process was complex, messy, and always evolving. Here we reflect on and document the process, identifying three key methodological principles that might guide the co-creation process for others. These principles embrace the unpredictable, emotional, and personal reality of bringing together diverse ideas and perspectives, as well as opening up possibilities for more creative ways of communicating and listening to what is seen, heard, and felt.  相似文献   

Teaching univariate measures of location‐using loss functions          下载免费PDF全文

Jon‐Paul Paolino 《Teaching Statistics》2018,40(1):16-23

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Information retrieval in the workplace: A comparison of professional search practices     

Tony Russell-Rose  Jon Chamberlain  Leif Azzopardi 《Information processing & management》2018,54(6):1042-1057

Legal researchers, recruitment professionals, healthcare information professionals, and patent analysts all undertake work tasks where search forms a core part of their duties. In these instances, the search task is often complex and time-consuming and requires specialist expertise to identify relevant documents and insights within large domain-specific repositories and collections. Several studies have been made investigating the search practices of professionals such as these, but few have attempted to directly compare their professional practices and so it remains unclear to what extent insights and approaches from one domain can be applied to another. In this paper we describe the results of a survey of a purposive sample of 108 legal researchers, 64 recruitment professionals and 107 healthcare information professionals. Their responses are compared with results from a previous survey of 81 patent analysts. The survey investigated their search practices and preferences, the types of functionality they value, and their requirements for future information retrieval systems. The results reveal that these professions share many fundamental needs and face similar challenges. In particular a continuing preference to formulate queries as Boolean expressions, the need to manage, organise and re-use search strategies and results and an ambivalence toward the use of relevance ranking. The results stress the importance of recall and coverage for the healthcare and patent professionals, while precision and recency were more important to the legal and recruitment professionals. The results also highlight the need to ensure that search systems give confidence to the professional searcher and so trust, explainability and accountability remains a significant challenge when developing such systems. The findings suggest that translational research between the different areas could benefit professionals across domains.  相似文献   

Injury prevention in male youth soccer: Current practices and perceptions of practitioners working at elite English academies     

Paul J. Read  Pablo Jimenez  Jon L. Oliver  Rhodri S. Lloyd 《Journal of sports sciences》2018,36(12):1423-1431

Forty-one practitioners inclusive of physiotherapists, sports scientists and strength and conditioning coaches from the academies of elite soccer clubs in the United Kingdom completed an on-line questionnaire which examined their: (1) background information; (2) perceptions of injury occurrence and risk factors; (3) screening and return to play; and (4) approach to designing and delivering injury prevention programmes with a response rate of 55% (41/75). Contact injuries were the most common mechanism reported and players between 13–16 years of age were perceived to be at the greatest risk. Pertinent risk factors included: reduced lower limb and eccentric hamstring strength, proprioception, muscle imbalances, and under developed foundational movement skills. Joint range of motion, jump tests, the functional movement screen, overhead and single leg squats were the most utilised screening methods. Training modalities rated in order of importance included: resistance training, flexibility development, agility, plyometrics and balance training. Training frequency was most commonly once or twice per week, during warm-ups, independent sessions or a combination of both. Injury prevention strategies in this cohort appear to be logical; however, the classification of injury occurrence and application of screening tools to identify “at risk” players do not align with existing research. The frequency and type of training used may also be insufficient to elicit an appropriate stimulus to address pertinent risk factors based on current recommendations.  相似文献   

An Interesting Fallacy Concerning Dynamical Supertasks     

Perez Laraudogoitia  Jon 《The British journal for the philosophy of science》2005,56(2):321-334

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