Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

Kawaii Killers and Femme Fatales: A Textual Analysis of Female Characters Signifying Benevolent and Hostile Sexism in Video Games     

Jessica E. Tompkins  Teresa Lynch  Irene I. Van Driel  Niki Fritz 《广播与电子媒介杂志》2020,64(2):236-254

ABSTRACT

Game developers potentially convey socio-cultural values about gender through design choices. This study interpreted the designs of 11 purposively selected female game characters, developed by studios located in the United States and Japan, through the lens of ambivalent sexism. This social psychological theory posits that sexism consists of hostile and benevolent attitudes about women. Two themes emerged across characterizations: bodies as objects, bodies as weapons and (in)dependence. Both consisted of empowering qualities paired with problematic beliefs about women. This analysis contributes to interdisciplinary literature by using an empirical perspective to interpret gender representations in video games.  相似文献   

Deploying a Corporate Learning System at the Innovative Startup     

O.S. Gaponova  I.A. Korshunov 《Russian Education & Society》2018,60(4):289-314

The article discusses an empirical study that was conducted by the authors, in which they surveyed focus groups of young innovative entrepreneurs who are at different stages of creating their own projects. The authors devote particular attention to how training programs for the founders and staff should be implemented as the startup develops from its early phases into a sustainable-growth business.  相似文献   

The Adolescent in the Online Game     

K.D. Khlomov  A.V. Kondrashkin  P.A. Kuzin  S.M. Kalyakina  K.I. Tyulkanova  D.P. Medvedev 《Russian Education & Society》2018,60(4):315-333

This article addresses the need for changes in current views on adolescent development. It presents observations of adolescent behavior in the online game Dragon Nest that were conducted by specialists from the Crossroads Center for Social and Psychological Adaptation and Adolescent Development, Moscow State University of Psychology and Education, in 2013. These observations helped form theories about age-specific tasks arising in adolescence. The restorative approach was selected as the theoretical basis for this work. This approach represents the practical application of the cultural-historical theory and the activity theory to the provision of social and psychological assistance to adolescents. An analysis of adolescent activity in a game, the structure of communication, and observations of adolescent relationships in online gaming space make it possible to form theories on the role of communication among peers in today’s society in terms of adolescent individuation and development.  相似文献   

Validity and reliability of a linear positional transducer across commonly practised resistance training exercises     

Harry F. Dorrell  Joseph M. Moore  Mark F. Smith  Thomas I. Gee 《Journal of sports sciences》2019,37(1):67-73

This study investigated the validity and reliability of the GymAware PowerTool (GPT). Thirteen resistance trained participants completed three visits, consisting of three repetitions of free-weight back squat, bench press, deadlift (80% one repetition maximum), and countermovement jump. Bar displacement, peak and mean velocity, peak and mean force, and jump height were calculated using the GPT, a three-dimensional motion capture system (Motion Analysis Corporation; 150 Hz), and a force plate (Kistler; 1500 Hz). Least products regression were used to compare agreeability between devices. A within-trial one-way ANOVA, typical error (TE; %), and smallest worthwhile change (SWC) were used to assess reliability. Regression analysis resulted in R² values of >0.85 for all variables excluding deadlift mean velocity (R² = 0.54–0.69). Significant differences were observed between visits 3-2 for bench press bar displacement (0.395 ± 0.055 m; 0.383 ± 0.053 m), and deadlift bar displacement (0.557 ± 0.034 m; 0.568 ± 0.034 m). No other significant differences were found. Low to moderate TE (0.6–8.8%) were found for all variables, with SWC ranging 1.7–7.4%. The data provides evidence that the GPT can be used to measure kinetic and kinematic outputs, however, care should be taken when monitoring deadlift performance.  相似文献   

Dynamic Transition Patterns in Acculturation Among Hispanic Adolescents     

Tae Kyoung Lee  Alan Meca  Jennifer B. Unger  Byron L. Zamboanga  Lourdes Baezconde-Garbanati  Melinda Gonzales-Backen  Elma I. Lorenzo-Blanco  Miguel Á. Cano  Sabrina E. Des Rosiers  Daniel W. Soto  Juan A. Villamar  Monica Pattarroyo  Karina M. Lizzi  José Szapocznik  Seth J. Schwartz 《Child development》2020,91(1):78-95

Acculturation consists of multiple domains (i.e., cultural practices, identifications, and values). However, less is known about how acculturation processes influence each other across multiple domains of acculturation. This study was designed to investigate transition patterns of acculturative processes within and across domains in a sample of 302 recent-immigrant Hispanic adolescents, M_age (SD) = 14.51 years (0.88) at baseline; male = 53%). Adolescents were assessed six times over a 3-year period. Latent profile analyses identified two profiles (high [or increasing] vs. low) for each domain at each timepoint. We found largely stable transition patterns in each domain over six timepoints. Importantly, sequential associations among profiles in acculturation domains were also detected. Implication for acculturation theory and research are discussed.  相似文献   

Female Athlete Triad Coalition risk assessment tool is an evidenced-based tool that is reliable and well-described     

Mary Jane De Souza  Nancy I. Williams  Kristen J. Koltun  Nicole C. A. Strock 《Journal of sports sciences》2020,38(9):996-999

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Challenges of remote assessment in higher education in the context of COVID-19: a case study of Middle East College     

Guangul  Fiseha M.  Suhail  Adeel H.  Khalit  Muhammad I.  Khidhir  Basim A. 《Educational Assessment, Evaluation and Accountability》2020,32(4):519-535

Educational Assessment, Evaluation and Accountability - Due to the unprecedented COVID-19 incident, higher education institutions have faced different challenges in their teaching-learning...  相似文献   

Segmentation techniques for recognition of Arabic-like scripts: A comprehensive survey     

Saeeda Naz  Arif I. Umar  Syed H. Shirazi  Saad B. Ahmed  Muhammad I. Razzak  Imran Siddiqi 《Education and Information Technologies》2016,21(5):1225-1241

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Introducing Children to Anatomy: “Getting to Know Our Bodies: The First Step Toward Becoming a Scientist”     

Gursel Ortug  Ahmet Midi  Deniz Sude Elbizim  Hasan Karaot  Elif Yılık  Işılsu Ezgi Uluışık 《Anatomical sciences education》2021,14(2):232-240

Museums are used in every discipline to collect, classify, and present information for scientific purposes. They also serve as an effective educational medium. Since the establishment of a boutique anatomy museum at Bahçeşehir University, lectures, conferences, and seminars have been organized there over the past four years on the history of human anatomy and the human body. In order to raise awareness about the need to make anatomy accessible to kindergarteners and school-aged children, rather than exclusively to undergraduate students, activities that are suited to a wide range of ages have been developed at the museum and at the anatomy laboratory. Four different sessions were conducted, including activities such as lectures using plastic models as props, shaping organs out of playdough, anatomy puzzles, watching cartoons, and examining specimens through a microscope. Healthy and pathologic anatomies were chosen to match daily themes. Among the kindergarteners and elementary school children, no grading was done, nor was any questionnaire administered; however, a survey was administered in the 10–12 age group (N = 64). According to the students' written feedback, 93.75% said they “are happy with microscope activities” while 84.37% said they “had so much fun” participating in the playdough activities. However, 18.75% criticized the activities, saying they “could have been longer.” In conclusion, it is believed that these “getting to know our bodies” activities that were hosted in the anatomy museum, including conferences, workshops, material preparation, and instructional movies, may play an important role in the development of a healthy society.  相似文献