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Frank Shushok Jr., T. Laine Scales, Rishi Sriram, and Vera Kidd share some initial thoughts about responses to their Campus Residential Experience Survey. Do you recognize your institution? 相似文献
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Shalini M Yogeeswari P Sriram D Induja S 《Journal of Zhejiang University. Science. B》2007,8(1):45-55
Objective： To study the effect of halo substitution on disubstituted aryl semicarbazones on the anticonvulsant potential and model the activity based on quantum mechanics. Methods： A series of twenty-six compounds of N^4-（4-bromo-3-methylphenyl） semicarbazones were synthesized and evaluated for the anticonvulsant activity in the maximal electroshock seizure （MES） and subcutaneous pentylenetetrazole （scPTZ） seizure threshold tests. Some potential compounds were also tested in the subcutaneous strychnine （scSTY） and subcutaneous picrotoxin （scPIC） seizure threshold tests. The synthesized compounds were tested for behavioral impairment and CNS （central nervous system） depression in mice. Quantum mechanical modelling was carried out on these compounds to gain understanding on the structural features essential for activity. Results： Some compounds possessed broad spectrum anticonvulsant activity as indicated by their effect in pentylenetetrazole, strychnine, picrotoxin and maximal electroshock seizures models in resemblance to other aryl semicarbazone derivatives reported earlier. The higher the difference in HOMO （highest occupied molecular orbital） and LUMO （lowest unoccupied molecular orbital） energy levels was, the greater was the activity profile. Conclusion： The pharmacophoric requirements for compounds to exhibit anticonvulsant activity that includes one aryl unit in proximity to a hydrogen donor-acceptor domain and an electron donor have been justified with the molecular orbital surface analysis of the synthesized compounds. 相似文献
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Leonardo Lesser-Rojas K. K. Sriram Kuo-Tang Liao Shui-Chin Lai Pai-Chia Kuo Ming-Lee Chu Chia-Fu Chou 《Biomicrofluidics》2014,8(1)
We have developed a two-step electron-beam lithography process to fabricate a tandem array of three pairs of tip-like gold nanoelectronic detectors with electrode gap size as small as 9 nm, embedded in a coplanar fashion to 60 nm deep, 100 nm wide, and up to 150 μm long nanochannels coupled to a world-micro-nanofluidic interface for easy sample introduction. Experimental tests with a sealed device using DNA-protein complexes demonstrate the coplanarity of the nanoelectrodes to the nanochannel surface. Further, this device could improve transverse current detection by correlated time-of-flight measurements of translocating samples, and serve as an autocalibrated velocimeter and nanoscale tandem Coulter counters for single molecule analysis of heterogeneous samples. 相似文献
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This study extended the scope of previous findings in human–computer interaction research within the computers are social
actors paradigm by showing that online users attribute perceptions of moral qualities to Websites and, further, that differential
perceptions of morality affected the extent of persuasion. In an experiment (N = 138) that manipulated four morality conditions (universalist, relativist, egotistic, control) across worldview, a measured
independent variable, users were asked to evaluate a Web site designed to aid them in making ethical decisions. Web sites
offered four different types of ethical advice as participants contemplated cases involving ethical quandaries. Perceptions
of the Web sites’ moral qualities varied depending on the type of advice given. Further, the Web sites’ perceived morality
and participants’ worldview predicted credibility, persuasiveness, and attitudes toward the Web sites. 相似文献
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Sriram Ramaswamy 《Resonance》2005,10(12):106-124
This article reviews the history of the phenomenon of Brownian motion, how it confirmed the molecular view of matter, and
how it led to the invention of nonequilibrium statistical mechanics. 相似文献
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Ganesa Yogeeswaran Charles E. Jebaraj Venkataraman Sriram 《Indian journal of clinical biochemistry : IJCB》1999,14(2):220-228
A comparison of the absorbance, enzyme/substrate concentration, reaction efficiency and sensitivity has been made for enzyme-based
clinical chemistry assays, using a conventional colorimeter versus a strip-microwell reader, in order to establish the value
of ultra-microchemical procedure, with reaction volume 87 μl (light path length=0.25 cm). By utilizing commercial kits available
for the quantitation of serum glucose, cholesterol and triglycerides, it has been established that the micro method is highly
cost effective (9–30 fold), reproducible and sensitive. Comparison of blood drawn by a finger prick (capillary) and venipuncture
for normal and pathological specimens show reproducibility between different laboratory technologists and in reference with
the values reported by an accredited reference laboratory. Since the micro method uses very little serum, it is most suitable
for analyses of small smaples, from large population-based field trials. However, the assay range has to be titrated for each
commercial kit to establish the enzyme/substrate equivalence. 相似文献
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A new residential college and a faculty-in-residence program demonstrate how student affairs educators and academic faculty at one institution have collaborated to create transformational learning experiences for their students. 相似文献
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Har Gobind Khorana pioneered study of transmembrane proteins at highest resolution possible through the application of biochemical techniques. His research on bacteriorhodopsin, a retinal based light driven proton pump from Halobacterium halobium spanned a range of ground breaking studies from membrane reconstitution, complete denaturation and refolding of a polytopic membrane protein, gene synthesis combined with genetically-directed protein modification and protein dynamic/kinetic analysis. His courage for tackling tough biochemical problems through enormous enthusiasm, building of a multi disciplinary team and maintain focus is a lesson for generations to come. 相似文献