Effects of moniliformin and selenium on human articular cartilage metabolism and their potential relationships to the pathogenesis of Kashin-Beck disease     

Clare E.HUGNES  Bruce CATERSON 《Journal of Zhejiang University. Science. B》2010,11(3):200-208

Objective:To investigate the effects of mycotoxin moniliformin (MON) on the metabolism of aggrecan and type II collagen in human chondrocytes in vitro and the relationship between MON and Kashin-Beck disease (KBD).Methods:Human chondrocytes were isolated and cultured on bone matrix gelatin to form an artificial cartilage model in vitro with or without MON toxin.Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.The expression of aggrecan and type II col...  相似文献   

Promotion of the articular cartilage proteoglycan degradation by T-2 toxin and selenium protective effect   总被引：2，自引：1，他引：2  

Li SY  Cao JL  Shi ZL  Chen JH  Zhang ZT  Hughes CE  Caterson B 《Journal of Zhejiang University. Science. B》2008,9(1):22-33

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