排序方式： 共有13条查询结果，搜索用时 15 毫秒
1.
Sagar Dholariya Deepak N. Parchwani Ragini Singh Madhuri Radadiya C. D. S. Katoch 《Indian journal of clinical biochemistry : IJCB》2022,37(2):131
The coronavirus disease 2019 is a highly contagious viral infection caused by SARS-CoV-2 virus, member of coronaviridae family. It causes life threatening complications due to complexity and rapid onset course of the disease. Early identification of high-risk patients who require close monitoring and aggressive treatment remains challengeable till date. Novel biomarkers which help to identify high risk patients at the early stage is high priority. Objective of this review to find utility of P-SEP, sTREM-1 and suPAR for diagnosis, risk stratification and prognosis of SARS-CoV-2 infected cases. Soluble receptors like, P-SEP, sTREM-1 and suPAR have been involved in immune regulation in SARS-CoV-2 infection and elevate more in severe cases. A comprehensive research of databases like PubMed, EMBASE, CNKI and Web of Science was performed for relevant studies. A total of nine out of fifteen research literature in initial screening were included for this review. Interestingly all studies have reported high levels of P-SEP, sTREM-1 and suPAR in SARS-CoV-2 infected cases and the biomarkers positively correlated with severity of infection. This implies that P-SEP, sTREM-1 and suPAR can be implemented as surrogate marker in blood profile for early diagnosis, risk stratification and prognosis in SARS-CoV-2 for better management in Indian population at the current situation. 相似文献
2.
Khan S Bhargava A Pathak N Maudar KK Varshney S Mishra PK 《Indian journal of clinical biochemistry : IJCB》2011,26(2):161-168
The present study evaluated the plausible role of circulating biomarkers in immune pathogenesis of chronic hepatitis considered
a priority in clinical hepatology. Total viral load of chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) patients
was quantified and correlation studies were performed with circulating levels of Th1/Th2 cytokines; C reactive protein and
circulating nucleosomes; glutathione reductase (GR) and superoxide dismutase. To our knowledge, the study is first among its
kind that validates strong positive correlation of viral load with IL-4, IL-6, GR in HBV and IL-6, IL-10, GR in HCV infections.
Although, multi-centric studies including large cohorts are required for translating our findings to clinical practice, however,
role of these biomarkers with potential diagnostic or prognostic significance might be helpful in clinical assessment of high-risk
individuals, thereby, designing interventional strategies, towards development of personalized medicare. The results of our
study also offer valuable insights of immune signaling mediators engaged in development of hepatocellular carcinoma. 相似文献
3.
Ying-ying LU Xian YANG Wen-qing CHEN Zhen-yu JU Zhang-fei SHOU Juan JIN Xiao-hui ZHANG Jiang-hua CHEN Hong JIANG 《Journal of Zhejiang University. Science. B》2014,15(6):566-574
Aging is one of the contributing risk factors for kidney diseases. Accumulating evidence prompts the view that telomere length in kidney tissue cells is an indicator for organismal aging. Previously identified aging markers (cathelin-related antimicrobial peptide (CRAMP), stathmin, elongation factor-1α (EF-1α), and chitinase) were associated not only with telomere driven aging in mice but also with human aging and chronic diseases. This study focuses on the relationship between these biomarkers and IgA nephropathy (IgAN) progression in the Chinese population. For 260 individuals, the four markers are determined in blind datasets using direct enzyme-linked immunosorbent assay (ELISA) and immunofluorescence staining. The expression levels of CRAMP and chitinase increased in blood plasma, urine, and kidney tissues during human IgAN progression. And for the other nephropathy, such as systemic lupus erythematosus (SLE), diabetic nephropathy (DN), and focal segmental glomerulosclerosis (FSGS), there is no protein upregulation with telomere shortening. Moreover, a combination of CRAMP and chitinase can distinguish patients with IgAN from healthy individuals with 88.2%/92.5% (plasma) and 74.3%/84.2% (urine) sensitivity/specificity. These data provide the experimental evidence that telomere shortening and related inflammatory proteins are associated with human IgAN, and it could be a new direction for the disease progression study. 相似文献
4.
Zhu LR Zhang WY Yu L Zheng YH Hu J Liao QP 《Journal of Zhejiang University. Science. B》2008,9(4):286-290
Serum samples from endometrial cancer (EC) patients and healthy females were analyzed using surface-enhanced laser desorption-ionization time-of-flight mass spectrometry (SELDI-TOF-MS) to discover the potential diagnostic biomarker for detection of EC. A preliminary training set of spectra derived from 40 EC patients and 30 healthy women were used to develop a proteomic model that effectively discriminated cancer patients from healthy women. The training set had a specificity of 100% and sensitivity of 92.5% in the EC detection. A blind test set, including 20 new cancer cases and 10 healthy women, was used to validate the sensitivity and specificity of this multivariate model, which had a corresponding results of 60% in specificity and 75% in sensitivity, respectively. The combination of SELDI-TOF-MS with bioinformatics tools could help find new biomarkers and establish the detection of EC with high sensitivity and specificity. 相似文献
5.
6.
Grizzi F Franceschini B Fiamengo B Russo C Dioguardi N 《Journal of Zhejiang University. Science. B》2007,8(4):217-220
Hepatocellular carcinoma （HCC） remains one of the major public health problems throughout the world. Although originally associated with tumorigenic processes, liver angiogenesis has also been observed in the context of different liver inflammatory, fibrotic, and ischemic conditions. Here we investigate the fractal dimension as a quantitator of non-Euclidean two-dimensional vascular geometry in a series of paired specimens of primary HCC and surrounding non-tumoral tissue, and discuss why this parameter might provide additional information regarding cancer behavior. The application of fractal geometry to the measurement of liver vascularity and the availability of a computer-aided quantitative method can eliminate errors in visual interpretation, and make it possible to obtain closer-to-reality numerals that are compulsory for any measurement process. 相似文献
7.
大负荷运动对大鼠血清OPG、sRANKL、骨代谢及骨量的影响 总被引：1，自引：0，他引：1
为研究大负荷运动对大鼠血清OPG、sRANKL、骨代谢生化因子(OC、ALP和TRAP)、骨密度(BMD)和骨量(BMC)的影响,20只6周龄大鼠随机分成2组:①对照组(Control group,CtrG)10只;②7周大负荷训练组(Overtraining group,OtrG)10只:进行7周的跑台训练。实验结束后所有大鼠处死并测定血清OPG、sRANKL、骨钙素(OC)、骨碱性磷酸酶(ALP)及抗酒石酸酸性磷酸酶(TRAP)。同时测定股骨、腰椎BMD、BMC。结果表明经过7周大负荷运动训练,OtrG组大鼠股骨BMC、BMD及腰椎BMC明显低于CtrG组大鼠。OtrG组大鼠血清OPG水平明显低于CtrG组,而sRANKL却高于CtrG组大鼠,OPG/sRANKL比率下降。OtrG组血清OC、ALP和TRAP明显高于CtrG组。研究提示过度运动导致OPG/sRANKL比例下降可能是骨代谢率增快、骨量丢失的重要原因。 相似文献
8.
LI Xiao-lin 《环球赛鸽科技》2014,(29)
This paper reviews the recent advances of marine biomarker. Biomarkers of marine microorganisms are also included. It is important to the origin of marine biological and the monitor and evaluation of m... 相似文献
9.
GRIZZI Fabio FRANCESCHINI Barbara FIAMENGO Barbara RUSSO Carlo DIOGUARDI Nicola 《Journal of Zhejiang University. Science. B》2007,8(4)
Hepatocellular carcinoma (HCC) remains one of the major public health problems throughout the world. Although originally associated with tumorigenic processes, liver angiogenesis has also been observed in the context of different liver inflammatory, fibrotic, and ischemic conditions. Here we investigate the fractal dimension as a quantitator of non-Euclidean two-dimensional vascular geometry in a series of paired specimens of primary HCC and surrounding non-tumoral tissue, and discuss why this parameter might provide additional information regarding cancer behavior. The application of fractal geometry to the measurement of liver vascularity and the availability of a computer-aided quantitative method can eliminate errors in visual interpretation, and make it possible to obtain closer-to-reality numerals that are compulsory for any measurement process. 相似文献
10.
GRIZZI Fabio FRANCESCHINI Barbara FIAMENGO Barbara RUSSO Carlo DIOGUARDI Nicola 《Journal of Zhejiang University. Science. B》2007,(4)
Hepatocellular carcinoma(HCC) remains one of the major public health problems throughout the world.Although originally associated with tumorigenic processes,liver angiogenesis has also been observed in the context of different liver in-flammatory,fibrotic,and ischemic conditions.Here we investigate the fractal dimension as a quantitator of non-Euclidean two-dimensional vascular geometry in a series of paired specimens of primary HCC and surrounding non-tumoral tissue,and discuss why this parameter might provide additional information regarding cancer behavior.The application of fractal geometry to the measurement of liver vascularity and the availability of a computer-aided quantitative method can eliminate errors in visual interpretation,and make it possible to obtain closer-to-reality numerals that are compulsory for any measurement process. 相似文献