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1.

Objective

The aim of this study was to evaluate the concentrations of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and the degree of homeostasis model assessment-insulin resistance (HOMA-IR) in patients with morbid obesity exposed to a three-week low-calorie diet and balneotherapy.

Methods

The study included 33 patients (25 females and 8 males; mean age 46 years) with body mass index (BMI) values of >40 kg/m2. Evaluations of CRP, IL-6, TNF-α, lipid profile, HOMA-IR, and fasting glucose were carried out before (baseline data) and three weeks after the treatment. The control group consisted of 20 healthy volunteers (15 females and 5 males) with a mean age of 39 years and BMI values of ≤24.9 kg/m2.

Results

In the blood of patients with morbid obesity we found significantly elevated levels of CRP, TNF-α, triglycerides, HOMA-IR and fasting glucose, but a decreased level of high density lipoprotein (HDL)-cholesterol, compared with the healthy individuals. The treatment resulted in about a 9.4% reduction in body weight from 122.5 to 111.0 kg and a significant decrease in the concentration of CRP, but no change in TNF-α or IL-6. HOMA-IR was significantly reduced.

Conclusion

The decrease in CRP level without changes in TNF-α or IL-6 concentrations after the low-calorie diet and balneological treatment, suggests that an essential amount of adipose tissue must be removed before proper adipocyte function is restored. The decrease in HOMA-IR indicates an improvement in insulin sensitivity, which is beneficial in obese patients.
  相似文献   
2.
CRP系统是以高校教育教学为核心,以ISO9000架构为流程总线的校园资源计划,其功能模块之一是图书馆子系统。分析当今高校图书馆运行机制中存在的突出问题,提出在CRP系统下,高校图书馆可以通过以用户为中心的业务流程重组,层级组织的扁平化、无界化、可视化,动态的全馆资源管理以及对馆员客观、量化、自动化的绩效考核等途径,融入CRP系统,实现高校图书馆运行机制的创新变革。  相似文献   
3.
近年来的研究显示,循环C-反应蛋白(C-reactive protein,CRP)浓度对很多慢性病的治疗及预后有重要的指导意义。运动作为大众健身的一种重要手段,在各种慢性病的预防及治疗中更具有不可忽视的作用。仅就运动、CRP与慢性病的关系作一综述。  相似文献   
4.
复方红景天口服液提高运动能力及消除疲劳的实验研究   总被引:10,自引:0,他引:10  
采用实验对比的方法,探讨复方红景天口服液对提高运动能力及消除疲劳的影响。结果表明。该口服液能明显提高实验对象大运动量训练期间及不同负荷量时的Hb,对运动期间的BUN有显著的降低作用:能提高实验对象的抗缺氧能力及力竭游泳时间;降低定量负荷时的BLA。提示,复方红景天口服液具有一定的提高运动能力及消除疲劳之功效。  相似文献   
5.
Serum CRP and uric acid levels were estimated in twenty-five patients with psoriasis (group III) before and after 12 weeks of treatment. Results were compared with a group of 25 normal subjects (group I) and a group of 25 patients of various skin diseases other than psoriatic lesion (group II). Mean value for CRP was found to be increased by more than 20 folds in patients with psoriasis, which was subsequently reduced to nearly 50% of the initial value after 12 weeks of treatment. These patients also showed hyperuricemia. Nearly 25% of these patients also exhibited arthritis. It is thus suggested that both CRP and uric acid levels should be monitored in patients with psoriasis.  相似文献   
6.
对急性减体重期间的女子拳击运动员给予联合营养补充,观察其肌肉力量、血红蛋白、肌酸激酶和C-反应蛋白等指标的变化,分析联合营养补充对运动员运动能力和免疫功能的影响。结果表明,联合营养补充可以减轻急性减体重对运动员运动能力所造成的影响,提高运动员的免疫能力。  相似文献   
7.
目的:探讨依达拉奉对脑出血患者血清IL-6、CRP的影响,研究依达拉奉对出血性脑损伤的保护机制;方法:选择70例脑出血患者随机分为依达拉奉组和对照组,1d、7d、14d、21d进行神经功能评分并检测患者血清IL-6、CRP水平;结果:两组7d、14d、21d较治疗前神经功能缺损有明显改善(P〈0.01),治疗后14d、21d与对照组比较神经功能缺损评分有统计学意义(P〈0.05);依达拉奉组与对照组比较,7d、14d、21d时血清IL-6、CRP水平下降(P〈0.05);结论:依达拉奉明显降低血清IL-6、CRP水平,从而减轻出血性脑损伤,对受损脑组织发挥保护作用。  相似文献   
8.
Low back pain is very disabling and dispiriting because of the physical impediment it causes and its psychological effects. Innumerable factors have been implicated in its etiology. In spite of improvements in diagnostic modalities, a considerable number of such cases fall in the ambiguous zone of unknown etiology or ‘idiopathic.’Early diagnosis of low back pain will allow effective prevention and treatment to be offered. This study was conducted to assess the contribution of vitamin D levels and other biochemical factors to chronic low back pain in such cases. All patients attending the orthopedics OPD for low back pain in whom a precise anatomical cause could not be localized, were prospectively enrolled in this study. We measured serum levels of glucose, calcium, phosphorus, uric acid, rheumatoid factor, C reactive protein, alkaline phosphatase, total protein, albumin and 25 (OH) D concentrations in 200 cases and 200 control samples. The patients showed significantly lower vitamin D levels compared to controls with p value < 0.0001. The maximum number of low back pain patients were in the age group of 31–50 years (42 %).The average BMI was 23.27 ± 5.17 kg/sq m, 73 % of total patient population were females and 27 % were known case of type 2 diabetes mellitus. Calcium, alkaline phosphatase, was positively correlated with vitamin D and glucose showed a negative correlation with vitamin D in the patient population. The problem of low back pain provides a challenge to health care providers. The problem in developing countries is compounded by ignorance to report for early treatment and occupational compulsions in rural areas and sedentary lifestyle in urban youth. The authors strongly recommend early frequent screening for vitamin D along with glucose, protein, albumin, calcium, phosphorus, CRP as part of general health checkup for non-specific body pain, especially low back pain.  相似文献   
9.
丙种反应性蛋白(CRP)是一种急性时相蛋白,对于疾病的诊断和预后有着重要意义。但其堆积会对心脏造成伤害。文章综述了影响体内CRP含量的多种因素,以及与心脏疾病关系的研究概况。提出通过控制其含量的方法来治疗心血管疾病在实验上是可行的。  相似文献   
10.
目的:探讨C反应蛋白(CRP)对稳定型冠心病患者的临床价值。方法:对46例经冠状动脉造影确诊的冠心病患者,排除急性冠脉综合征和急性心肌梗死,以血管狭窄≥50%作为诊断冠心病阳性标准。患者于入院次日查CRP,对CRP指标的判断采用我院正常值参考标准,分为正常与异常,即CRP≤8.2mg/L者均视为正常,>8.2mg/L均视为异常。结果:46例稳定型冠心病患者,按照病变累及的冠状动脉支数及病变狭窄程度两种分析方法,CRP均为正常。结论:CRP对稳定型冠心病的诊断,病变严重程度的判断无临床价值。  相似文献   
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