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T. K. Sankaranarayanan C. Subramanyam 《Indian journal of clinical biochemistry : IJCB》2003,18(1):1-4
A comparative study was conducted to evaluate calcineurin activity in normal pancreatic beta cells and insulinoma cells in
relation to their oxidative state. In comparison to normal islets, insulinoma cells had enhanced oxidative stress as evidenced
by increased content of thiobarbituric acid reactive substances. In addition, diminished activity of calcineurin in insulinoma
cells was concomitant with decreased content of reduced glutathione and glutathione peroxidase activity signifying diminished
antioxidant status in these cells. Culturing insulinoma cells in presence of the calcineurin inhibitor cyclosporin A resulted
in further decrease of calcineurin activity with restoration of glutathione peroxidase but without restoration of reduced
glutathione levels. These results indicate that an estimate of oxidative stress in pancreatic islets and insulinoma cells
can be obtained by assaying calcineurin activity. 相似文献
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Wang S Hu HT Wen SQ Wang ZJ Zhang BR Ding MP 《Journal of Zhejiang University. Science. B》2008,9(6):496-499
We described a female patient with insulinoma who experienced recurrent episodes of automatism, confusion and convulsion. Furthermore, her electroencephalography (EEG) findings resembled the pattern in complex partial seizures with secondary generalization. The interictal EEG showed spikes and sharp waves, as well as focal slowing over the left temporal lobe, and the ictal EEG revealed generalized spikes and sharp waves associated with diffused slowing. She was initially misdiagnosed as pharmacoresistant epilepsy. After the insulinoma was found and surgically removed, her EEG turned normal and she was seizure-free during the 4-year follow-up. This report highlights the need for careful reassessment of all seizures refractory to medication, even for the patients associated with epileptiform discharges on EEG. 相似文献
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