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Geng Y Shi GH Jiang Y Xu LX Hu XY Shao YQ 《Journal of Zhejiang University. Science. B》2005,6(1):22-27
Objective: To investigate the role of 99mTc-TRODAT-1 SPECT in diagnosis and assessing severity of idiopathic Parkinson's disease (PD). Methods: Thirty-eight patients with primary, tentative diagnosis of PD and eighteen age-matched normal controls were studied with 99mTc-TRODAT-1 SPECT imaging. The regions of interests (ROIs) were drawn manually on cerebellum (CB), occipital cortex (OC) and three transverse plane slice-views of striatums, the semiquantitative BG (background)/[(OC CB)/2] were then calculated. Results: A lower uptake of 99mTc-TRODAT-Ⅰ in striatums were displayed in thirty-six out of thirty-eight PD patients by visual inspection, compared to controls. In twenty-four PD cases with HYS (Hoehn and Yahr scale) stage I, a greater loss of DAT uptake was found in striatum and its subregions contralateral striatum to the affected limbs than in the same regions of the controls, although the striatal uptake was bilaterally reduced. Using Spearman correlation analysis showed that the reduction of the uptake ratios significantly correlated with the UPDRS in striatum and all its subregions in the PD group (P＜0.05), a similar change was also found in the putamen by using the rating scale of Hoehn and Yahr (P＜0.05).However, analysis of variance (ANOVA) did not show any relationship between the decreasing uptake of 99mTc-TRODAT-1 and increasing severity of PD patients, although the specific uptake of 99mTc-TRODAT-Ⅰ was continuously decreased in the striatum by visual inspection with the progress of PD from HYS stage Ⅰ to Ⅲ. Conclusion: 99mTc-TRODAT- 1 SPECT imaging may serve as a useful method for improving the correct diagnosis of PD. In assessing the role of99mTc-TRODAT- 1 SPECT in disease severity of PD, UPDRS can offer a comprehensive index, although the Hoehn and Yahr assessment may be available in part. 相似文献
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目的探讨SPECT在癫痫诊断中的价值。方法通过比较SPECT、头颅MRI、常规脑电图等辅助检查方法对癫痫患者的检出率,探讨SPECT在诊断中的价值。结果SPECT、常规脑电图、头颅MRI的检出率分别为80．7％,66．7％,47．6％。,结论通过对比SPECT检出率明显高于常规脑电图、MRI的检出率。 相似文献
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Díaz MP Rizo OD Díaz AL Aparicio EE Díaz RR 《Journal of Zhejiang University. Science. B》2006,7(12):947-956
A discriminant method for optimizing activity in nuclear medicine studies is validated by comparison with ROC （received operating characteristic）-curves. The method is tested in 21 single photon emission computerized tomography （SPECT）, performed with a cardiac phantom. Three different lesions （Lb L2 and L3） were placed in the myocardium-wall by pairs fbr each SPECT. Three activities （84, 37 or 18.5 MBq） of 99mTc were used as background. Linear discriminant analysis was used to select the parameters that characterize image quality among the measured variables in the images [（Background-to-Lesion （B/Li） and Signal-to-Noise （S/N） ratios）]. Two clusters with different image quality （P=0.021 ） were obtained. The ratios B/Lj, B/L2 and B/L3 are the parameters used to construct the function with 100% of cases correctly classified into the clusters. The value of 37 MBq was the lowest tested activity for which good results for the B/Li ratios were obtained. The result coincides with the applied ROC-analysis （r=0.89）. 相似文献
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DíAZ Marlén Pérez RIZO Oscar Díaz DíAZ Adlin López APARICIO Eric Estévez DíAZ Reinaldo Roque 《Journal of Zhejiang University. Science. B》2006,(12)
INTRODUCTION Image quality in nuclear medicine tomography is critically dependent on the activity undergone by the patient. The optimal activity is the smallest amount of activity which preserves diagnostic accuracy. Nev- ertheless, the optimum depends on the gamma camera used for imaging, the size of the patient and the im- aging application (Mattsson et al., 1998). To optimize, one has to study how diagnostic accuracy depends on the activity undergone for each particular study, taking i… 相似文献
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Objective:To investigate the role of ~(99m)Tc-TRODAT-1 SPECT in diagnosis and assessing severity of idiopathicParkinson's disease(PD).Methods:Thirty-eight patients with primary,tentative diagnosis of PD and eighteen age-matchednormal controls were studied with ~(99m)Tc-TRODAT-1 SPECT imaging.The regions of interests(ROIs)were drawn manually oncerebellum(CB),occipital cortex(OC)and three transverse plane slice-views of striatums,the semiquantitative BG(back-ground)/[(OC CB)/2]were then calculated.Results:A lower uptake of ~(99m)Tc-TRODAT-1 in striatums were displayed inthirty-six out of thirty-eight PD patients by visual inspection,compared to controls.In twenty-four PD cases with HYS(Hoehn andYahr scale)stage Ⅰ,a greater loss of DAT uptake was found in striatum and its subregions contralateral striatum to the affectedlimbs than in the same regions of the controls,although the striatal uptake was bilaterally reduced.Using Spearman correlationanalysis showed that the reduction of the uptake ratios signifi 相似文献
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