健身瑜伽对中老年女性慢性腰痛的防治研究   总被引：6，自引：0，他引：6  

陈丽霞 《北京体育大学学报》2006,29(1):85-86,109

为研究健身瑜伽对中老年女性慢性腰痛的防治效应,将70名中老年慢性腰痛病人分成A、B两组,C组由正常组35名无腰痛病史的中老年女性组成.对A、C进行9个月健身瑜伽训练.运用Neuromatic 2000 M/C神经肌电仪测试各组训练前后骶棘肌肌电指标,PPX-L型双能X线骨度仪测量各组训练前后骨密度值,分别进行组间比较.结果:慢性腰痛组(A、B)训练前腰背肌波幅低于正常组(P<0.01)时程大于正常组(P<0.01),训练之后腰痛组(A)和正常组(C)波幅都得到提高(P<0.01和P<0.05)时程都降低(P<0.01和P<0.05).疗效评定得出慢性腰痛治愈显效率达82.86%.结论:健身瑜伽对中老年女性慢性腰痛具有较好的防治作用.  相似文献   

慢性低氧及跑台训练对大鼠骨骼肌肌球蛋白重链(MHC)亚型基因表达的影响   总被引：2，自引：2，他引：0  

潘同斌  王瑞元  袁建琴  毛杉杉 《北京体育大学学报》2005,28(1):57-59

为研究慢性低氧及跑台训练对大鼠骨骼肌肌球蛋白重链(MHC)亚型基因表达的影响,对揭示肌肉收缩蛋白性能的变化机制具有特定的意义.取健康SD雄性大鼠28只,随机分成4组进行试验,采用半定量反转录聚合酶链式反应(RT-PCR)法,测定骨骼肌MHC Ⅰ、Ⅱa、Ⅱx、Ⅱb四种亚型的mRNA基因表达.结果表明:与常氧对照组(C)相比,HC及NT组MHC各亚型mRNA表达量总体呈上升趋势(P＜0.05),仅仅低氧训练组(HT)MHC-Ⅱa亚型mRNA表达量明显下降(P＜0.05);另一方面,MHC各亚型mRNA所占百分比分析显示,慢性低氧能导致MHC亚型mRNA表达出现"由慢到快"变化趋势.另外,慢Ⅰ型百分比并未受慢性低氧及训练的影响.  相似文献   

In vitro study on ribozyme against hepatitis C virus     

Chen Zhi  Liu Yong  Liu Ke-zhou  R. H. Dennin  Dou Jun  U Reinhard 《浙江大学学报(A卷英文版)》2001,2(1):100-103

Objective: To determine the effective nucleotide sites of ribozymes against HCV, and obtain a highly effective, nontoxic and inexpensive antisense ribozyme specific for HCV. Methods: Two effective ribozymes, targeted to HCV 5’NC region and C region, were designed and synthesized. Eukaryotic expression vectors, pSV2-gpt. CD-SR (, containing either HCRZNC or HCRZC were constructued and transfected into MT-2 cells, which had been infected by HCV. Quantitative PCR and hydridization were used to determine the effect of inhibition of HCV by ribozymes. Results: HCRZNC and HCRZC suppressed the replication of HCV by 54.7% and 62.1%, respectively. Furthermore, when both ribozymes were cotransfected into cells, they suppressed replication by 78.8%. Conclusion: Two specific antisense ribozymes have strong inhibitory effects on the replication of HCV in cultured cells, and have better effect when used together.  相似文献   

一氧化氮合酶在病毒性肝炎中作用的研究进展     

金祥宁  丁明星 《金华职业技术学院学报》2006,6(3):72-73,79

一氧化氮(NO)参与肝细胞的多项生理功能调节,参与病毒性肝炎的病理过程。一氧化氮合酶(NOS)为产生NO的限速酶,与NO的各种生理功能密切相关。本文综述了NOS基因在正常肝组织和病毒性肝炎的不同表达情况及其作用和意义。  相似文献   

复方甘草酸苷联合拉米夫定治疗慢性乙型肝炎的临床研究     

陈耀凯  王宇明  方蓉 《大连大学学报》2006,27(4):31-34

[目的]观察复方甘草酸苷对慢性乙型肝炎患者血清病毒学标志的影响．[方法]采用复方甘草酸苷联合拉米夫定治疗30例慢性乙肝患者,并与30例拉米夫定单药治疗患者比较,观察治疗后血清病毒学标志及肝功能指标的变化．[结果]治疗12周时联合治疗组血清HBeAg／抗-HBe转换率明显高于对照组；治疗12周和24周时联合治疗组肝功能指标复常率明显高于对照组．[结论]复方甘草酸苷治疗慢性乙型肝炎可能有助于患者在拉米夫定治疗过程中早期发生HBeAg／抗-HBe血清转换．  相似文献   

慢加急性肝衰竭不同转归患者体温变化特点及护理对策     

陈勇妮  王丹菊  潘红霞 《大众科技》2016,(7)

目的:明确慢加急性肝衰竭不同转归患者体温变化特点,并制定相应的护理对策。方法:收集11例慢加急性肝衰竭患者,死亡患者5例,出院患者6例,采用重复测量方差分析比较不同转归患者体温随住院时间的特点。结果:在住院第8天左右,死亡组患者体温升高,与出院患者比较差异有统计学意义(F=17.451,P0.05)。护理对策:要进一步提高护理级别,加强基础护理,严格执行无菌操作,将陪护人员作为预防感染宣教对象。  相似文献   

孝感市老年人常见慢性病的调查分析     

周伟  张晶  陈漫  汪德忠  涂豆豆 《孝感职业技术学院学报》2011,(3):109-112

目的：调查孝感市老年人群常见疾病分布特征,为预防和保健措施提供依据。方法：对1785名55岁以上老年人进行问卷调查,获取常患疾病资料。结果：孝感市老年人群患病率较高的依次是高血压病（28．01％）,颈腰椎疾病（19．33％）、风湿病（12．32％）、心脏病（9．24％）。各疾病性别间差异无统计学意义（P〉0．05）,部分疾病在年龄、城乡、运动习惯间差异有统计学意义（P〈0．05）。结论：孝感市老年人群慢性疾病患病率较高,而且往往同时患有多种疾病,人均慢性病频率为98．04％（男性101．0％,女性93．88％）,严重影响老年人的生活质量,要引起社会的高度重视。  相似文献   

Compensatory changes in physical activity and sedentary time in children and adolescents with cystic fibrosis     

Kelly A. Mackintosh  Nicola D. Ridgers  Melitta A. McNarry 《Journal of sports sciences》2019,37(13):1506-1511

Physical activity (PA) is a key element in Cystic Fibrosis (CF) treatment strategies, yet little is known as to whether activity compensation occurs. This study examined whether PA and/or sedentary time on one day were temporally associated with time spent in these intensities the following day in youth with CF. Time spent sedentary and in different PA intensities were objectively-measured for seven consecutive days in 50 youth (22 boys; 12.0 ± 2.7 years); 25 with mild-to-moderate CF and 25 age- and sex-matched controls. Multilevel analyses (day and child) were conducted using generalised linear latent and mixed models. On any given day, every additional 10 minutes spent in sedentary time or moderate-to-vigorous physical activity (MVPA) were associated with 1.9 (95%CI: ?3.6 to ?1.2) and 12.4 (95%CI: ?22.1 to ?2.9) minutes less sedentary time the following day, respectively. These temporal associations were also observed when split by group (3.1 vs. 1.9 minutes for healthy and CF, respectively). These findings indicate that youth do not compensate their PA, irrespective of disease status, between days, but may compensate their sedentary time between days. Experimental studies are warranted to fully elucidate whether compensatory responses to PA and sedentary time occur, which is fundamental for informing PA promotion strategies.  相似文献   

Resting MAPK expression in chronically trained endurance runners     

Justin X. Nicoll  Andrew J. Galpin  Donald B. Thomason  Christopher A. Moore 《European Journal of Sport Science》2017,17(9):1194-1202

Purpose: There is a paucity of research investigating the expression of mitogen-activated protein kinases (MAPK) in chronically trained (CT) athletes. Thus, it is unclear how MAPK may contribute to performance and muscle adaptation in CT subjects. The purpose of this study was to determine MAPK total protein, and phosphorylated expression of extracellular signal-regulated kinases 1 and 2 (ERK1/2), c-Jun N-terminal kinase (JNK), and p38-MAPK (p38) between untrained, and chronically trained runners. Methods: Tissue samples were analysed from sedentary (SED; n?=?5) controls and chronically trained runners (CT; n?=?5). Resting muscle biopsy samples were analysed for total-MAPK – and ratio of phosphorylated/total (p-MAPK) – ERK1/2, JNK, and p38-MAPK via western blotting. Mann–Whitney U tests and effect sizes were utilized to determine differences in total MAPK protein content and phosphorylation status between SED and CT subjects. Results: There was no difference in total-MAPK expression between SED and CT (p?>?.05). p-p38-MAPK tended to be greater for CT compared to SED (p?=?.07). There were moderate effect sizes of decreased pERK/total-ERK (d?=??0.69) and increased pJNK/total-JNK (d?=?0.54) in CT compared to SED. There was a positive correlation between p-p38-MAPK/total-MAPK and the percentage of type I fibres (r?=?0.73, p?=?.016). Conclusion: Contrary to previous studies, chronic endurance training does not greatly influence total MAPK protein expression in chronically trained runners. However, resting phosphorylation of p38-MAPK may contribute to enhanced oxidative metabolism at chronically trained levels. These alterations are likely involved in the different physiological adaptations that occur following long-term training or at highly competitive levels.  相似文献   

有氧运动对慢性应激大鼠脑海马区神经可塑性的影响     

戈含笑  魏宏文  张有志  高颀  薛瑞  陈红霞 《北京体育大学学报》2017,40(5):39-45

摘要：目的：以神经元和神经胶质细胞相关神经生物学变化为切入点,探讨有氧运动对慢性应激大鼠脑海马区神经可塑性的影响。方法：以SD大鼠为研究对象,按照体重均衡分为对照组（CON）、慢性应激模型组（MOD）、氟西汀组（FLU）、低强度运动组（LIR）和中等强度运动组（MIR）。给予大鼠4周慢性应激,并分别伴随氟西汀给药、低强度或者中等强度的运动干预。4周后,通过开场实验、蔗糖饮水实验、新奇抑制摄食实验以及新物体识别实验检测运动对慢性应激大鼠抑郁样行为、焦虑样行为以及认知障碍的影响;同时,利用酶联免疫法和蛋白免疫印迹法,检测运动对慢性应激大鼠血清皮质酮、海马内前炎因子IL1-β,以及蛋白GFAP、S100β、BDNF、p-ERK、p-CREB表达的影响,探讨运动抗抑郁的行为学效应和作用机制。结果：1）低强度和中等强度运动能够显著增加慢性应激大鼠的开场活动、缩短新奇抑制摄食潜伏期,同时提高慢性应激大鼠新物体的识别指数;2）运动有效逆转了慢性应激大鼠血清皮质酮的异常升高,同时降低海马内前炎性因子IL1-β的分泌;3）运动可显著星形胶质细胞的标志性功能蛋白GFAP和S100β的表达水平,增强慢性应激大鼠的BDNF/ERK/CREB信号转导通路中重要蛋白BDNF、p-ERK、p-CREB的表达。结论：运动可以通过提高慢性应激大鼠脑海马区神经可塑性来达到抗抑郁的目的。可能与以下因素有关：1）运动调节血清皮质酮的异常升高,降低海马内前炎性因子的释放,同时,提高与神经胶质细胞相关蛋白GFAP和S100β活性,从而起到神经元保护的作用;2）运动可以通过激活CREB,BDNF以及ERK等重要信号蛋白的表达,提高神经营养作用,促进神经元的生长,增加神经可塑性和神经发生来发挥抗抑郁作用。  相似文献