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口腔扁平苔藓上皮细胞凋亡和P53的表达及关系的研究 总被引：1，自引：0，他引：1
尚云峰 《岳阳职业技术学院学报》2006,21(6):42-46
目的:目前,国内外对细胞凋亡与OLP、OLP与P53的关系有一定的研究,对OLP病变过程中凋亡与P53的关系暂未见报道。通过本研究,探讨OLP的可能发病机理。方法:采用甲基绿派诺宁法检测30例OLP患者及20例正常对照者口腔上皮细胞凋亡的阳性表达,用免疫组化SABC法检测P53,CyclinD1,ki67蛋白在两组上皮中的分布和表达。结果:(1)正常组与OLP组凋亡细胞阳性指数分别为0.69±0.25,1.98±1.07,t=5.28(P=0.03<0.05),有统计学意义;(2)正常组与OLP组P53蛋白阳性指数分别为5.15±3.12,20.73±10.56,t=6.35(P=0.001<0.05),有统计学意义;(2)P53阳性细胞指数与凋亡指数呈正相关。其相关系数分别为r=0.8209,P<0.01有统计学意义。结论:(1)细胞凋亡及凋亡相关因子P53蛋白的异常表达可能导致OLP的病变。(2)二者的平衡失调导致了OLP病变的反复发作。 相似文献
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Seshadri developed many reagents and synthetic procedures which he used for elucidation and synthesis of natural products,
in particular flavonoids. 相似文献
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During the eighties second level students in Ireland were involved in the primary acquisition of data for scientists assessing air quality. The techniques and methodology devised by the scientists were pilot tested in Cork city in 1982. These included mapping lichen and leaf yeast distributions, and measuring acidity of precipitation. Local teachers were contacted about participating in the project. The teachers attended seminars on the techniques to be used, were supplied with background information, and were provided with the scientific equipment to conduct the survey. Following the success of the pilot project, other areas in the country were surveyed for air quality with the cooperation of students and teachers. In 1988, the research team from An Foras Forbartha and Trinity College Dublin collaborated with over 100 secondary science teachers and their students to assess the air quality of the Greater Dublin area. After the completion of each survey members of the team visited the schools, discussed the results with the teachers and students, and presented them with a copy of the final report. For various reasons the research team could not conduct further studies. However, some students in the cooperating schools did continue and have presented their findings over a number of years at a national student science competition. In addition, the survey methodologies are expected to reappear as part of a new second level curricular reform in Ireland. 相似文献
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