Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

Digital Module 05: Diagnostic Measurement—The G‐DINA Framework https://ncme.elevate.commpartners.com     

Wenchao Ma  Jimmy de la Torre 《Educational Measurement》2019,38(2):114-115

In this ITEMS module, we introduce the generalized deterministic inputs, noisy “and” gate (G‐DINA) model, which is a general framework for specifying, estimating, and evaluating a wide variety of cognitive diagnosis models. The module contains a nontechnical introduction to diagnostic measurement, an introductory overview of the G‐DINA model, as well as common special cases, and a review of model‐data fit evaluation practices within this framework. We use the flexible GDINA R package, which is available for free within the R environment and provides a user‐friendly graphical interface in addition to the code‐driven layer. The digital module also contains videos of worked examples, solutions to data activity questions, curated resources, a glossary, and quizzes with diagnostic feedback.  相似文献   

以整体性环境叙事构建中国绿色国际传播体系——以《中国日报》“北向追象”报道为例     

吴沁宇  韦清琦 《传媒观察》2022,(1)

《中国日报》于2021年夏开始的对云南亚洲象北行的专题英文报道,利用多平台综合信息展示了中国环保实践,在全球广受好评。本次报道与习近平总书记构建中国话语和中国叙事体系的理念十分相符,其中生态理念的本土特质得到凸显,官民一体的形象得到了积极塑造,而中国科技能力的展现也融入了一个好故事的解说之中。中国当代的环境叙事必须反映人与自然的生命共同体与人类命运共同体的完整结合;"北向追象"所构造的具有中国特色的环境叙事之所以取得了很好的外宣效果,跟其紧扣这一完整性的表达密不可分,对于今后的国际传播工作也提供了颇多启示。  相似文献   

对民国档案文件级整理工作的思索     

陈晓敏 《山西档案》2006,(1):35-37

在建国后五十多年时间里，档案工作在民国档案整理工作中，遵循档案形成的客观规律，依据全宗原则、利用原基础原则，对全国民国档案进行了案卷级整理工作，逐步建立了包括全宗目录、案卷目录、人名目录、地名目录等在内的民国档案目录体系，部分档案馆还建立了馆藏民国档案案卷级机读目录数据库。不过，随着民国档案开放力度增大，对档案内容信息的揭示提出了更高的要求，原有的民国档案整理成果已难满足现有的民国档案工作需要，对民国档案信息作进一步开发，即开展民国档案件级整理工作已逐渐被提上议事日程，但这项工作对我们来说是崭新的，我们需要对其必要性、和案卷级整理工作的衔接、应结合档案馆数字化工作开展以及在整理人员启用上如何谋求社会力量的支援等等问题加以认真思索。  相似文献   

COUNTER R5的新特性及对图书馆的影响     

侯景丽 《图书馆杂志》2018,(12):46-55

COUNTER是规范网络化电子资源使用统计报告数据处理、审核和提交的国际化标准,是图书馆电子资源使用量统计和评估的核心要素。目前COUNTER已经发布了最新版本R5,了解R5的新特性及与之前版本的不同对于图书馆的电子资源统计工作具有重要意义。本文拟从COUNTERR5的报告设置、报告的指标类型、数据类型、访问类型和其他完善报告的属性来解析R5,同时介绍R5对SUSHI收割的影响、"持续维护"的概念、R5发布对图书馆的影响和R5实施的重要时间节点,同时也对R5较之R4的发展和不同进行了比较和分析。COUNTERR5的主要关注点是一致性、清晰性和简单性,较之COUNTERR4有了明显的完善,同时包含了持续的维护过程,允许对代码进行更新而不必再引入一个全新的版本,解决了版本升级会对供应商和图书馆带来的各种时间和人员成本的影响。  相似文献   

新时期大学生思想政治教育工作方法研究     

王秋博 《沈阳教育学院学报》2010,12(3):79-80

针对当前由＂90后＂构成的大学生主体,总结了其相对于＂80后＂所呈现出的新特点,提出了新时期大学生思想政治教育工作,应从完善与学生的沟通途径、构建与家长的全方位沟通机制、营造和谐的集体氛围、打造良好的社会环境四方面进行。  相似文献   

社鼠、雷琼社鼠和针毛鼠染色体分类的研究   总被引：2，自引：0，他引：2  

江庆澜 《中山大学学报论丛》1995,(1)

社鼠、雷琼社鼠和针毛鼠都是山地栖息种类，它们染色体的2n数目和形态明显有别于同属的其他各种．体现出它们之间的亲缘关系较近，它们间的核型演化是通过罗伯逊易位和缺失途径，社鼠、雷琼社鼠和针毛鼠有着不同于属中其他种类的生态位，把它们另作一属会恰当些；社鼠和雷琼社鼠的地理分布有所不同．但染色体组型并不差异．认为它们间可能仅是毛色变异，而不存在两个亚种之分．  相似文献   

The Decline of the ‘Elite’ Sport Officials and the Dissolution of the Israeli Sport Association     

Udi Carmi 《国际体育史杂志》2016,33(6-7):683-703

This historical study will examine the rise of a hegemonic group of sports officials in Israel during the period between 1948 and 1996. The formation of this group is a unique phenomenon of the Israeli sport society. The main argument of the study is that officials of rival sport centres, ‘Hapoel’ and ‘Maccabi’, founded a joint elite group as a side effect of the ‘fifty-fifty’ agreement, signed in 1951. The agreement stated that the Israeli Sport Association, the National Olympic Committee and the Israeli Football Association would be mutually led by officials of both organizations. The members of this elite group, who enjoyed access to economic resources and other benefits, adopted a hedonistic lifestyle, in contrast to the social ethos of Israeli society in the first and second decades of the State. Three events dismantled the group in the middle of the 1990s. The first one was the establishment of the Elite Sport Department in 1984. The second was the establishment of independent Federations by Yadin Machnes. The third was the Maliniak Commission Report. These three events led to the collapse of the Israeli Sport Association in 1996 and to the fall of the Israeli hegemonic group.  相似文献   

Being ‘nice’ or being ‘normal’: girls resisting discourses of ‘coolness’     

Carrie Paechter  Sheryl Clark 《Discourse: Studies in the Cultural Politics of Education》2016,37(3):457-471

In this paper we consider discourses of friendship and belonging mobilised by girls who are not part of the dominant ‘cool’ group in one English primary school. We explore how, by investing in alternative and, at times, resistant, discourses of ‘being nice’ and ‘being normal’ these ‘non-cool’ girls were able to avoid some of the struggles for dominance and related bullying and exclusion found by us and other researchers to be a feature of ‘cool girls’ groupings. We argue that there are multiple dynamics in girls' lives in which being ‘cool’ is only sometimes a dominant concern. There are some children for whom explicitly positioning themselves outside of the ‘cool’ group is both resistant and protective, providing a counter-discourse to the dominance of ‘coolness’. In this paper, which is based on observational and interview data in one school in the south of England, we focus on two main groupings of intermediate and lower status girls, as well as on one ‘wannabe’ ‘cool girl’. While belonging to a lower status group can bring disadvantages for the girls we studied, there were also benefits.  相似文献   

Challenging from the margins into the mainstream—improving renal services in a collaborative and entrepreneurial spirit     

Margaret Attwood 《Action Learning: Research and Practice》2007,4(2):191-198

Can the development, both clinical and managerial, of practitioners involved in healthcare be enriched by connecting action learning principles and practice with research on ‘tempered radicals’? Might such connection also assist the efforts of patients and their advocates to create more holistic approaches to patient care? This paper explores these questions with reference to a UK Department of Health project to improve renal services. The prime focus is the experience of a set of set advisers who ‘held the ring’ on the project, supporting the work of the sets and attempting to make sense of the emerging learning.  相似文献