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Iron deficiency evolves slowly through several stages. Early iron deficiency caused a depletion in iron stores as shown by
a reduction in the levels of hepatic non-heme iron in the new born of iron deficient mothers. Of particular importance is
the effect on central nervous system, which leads to the defects in the cognition and learning processes in humans. Evidence
is strong that in many under developed countries iron deficiency is the main cause of anaemia and supplementation under trial
conditions may prevent some defects of iron deficiency but not all. 相似文献
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Emokpae MA Uwumarongie OH Osadolor HB 《Indian journal of clinical biochemistry : IJCB》2011,26(1):57-61
Proteinuria in subjects with sickle cell anaemia (SCA) is an indication of an ongoing renal insufficiency and it’s prevalence
varies between sexes. We evaluated sex differences in the activities of Lecithin: cholesterol acyltransferase (LCAT), Lipoprotein
lipase (LPL) and the levels of lipoproteins in SCA patients with proteinuria. Fifty SCA patients (30 males aged: 26.4 ± 7.3 years
and 20 females, aged 25.4 ± 2.6 years) and 50 age and sex matched control SCA patients were recruited for the study. Random
urine specimens were collected and tested for the presence of albumin by urine dipstick technique. A 24 h urinary protein
was quantitated using sulphosalicylic acid technique. Fasting serum total cholesterol, triglyceride, urea and creatinine were
determined using enzymes catalyzed colorimetric methods. HDL cholesterol was determined in the supernatant after precipitation
with manganese chloride–phosphotungstic acid solution. LCAT was measured using the Anasolv LCAT assay with proteoliposome
as substrate. LPL was determined by incubating the serum in glyceryl trioleate substrate, the glycerol liberated was measured
in an aliquot of the incubating mixture. In male SCA controls there was 18.2 and 6.9% increase in the activities of LPL and
LCAT respectively when compared with females but in SCA patients with proteinuria there was 8.4 and 5.2% decreases in the
male SCA patients compared with females. The concentration of 24 h urine protein in the SCA male subjects with proteinuria
was significantly higher (0.25 g/day; P < 0.001) compared with the SCA female patients with proteinuria (0.09 g/day). There are sex differences in the activities
of LCAT and LPL in SCA patients with proteinuria. Metabolism of these lipolytic enzymes may be modulated differently in SCA
patients with proteinuria. 相似文献
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急性ST段抬高型心肌梗死继发心脏破裂的预测因素分析 总被引：2，自引：0，他引：2
Geng QIAN ;Chen WU ;Yun-dai CHEN ;Chen-chen TU ;Jin-wen WANG ;Yong-an QIAN 《Journal of Zhejiang University. Science. B》2014,15(12):1048-1054
研究目的：心脏破裂是急性ST段抬高型心肌梗死最严重的并发症之一,病情凶险,死亡率高。通过明确心肌梗死后出现心脏破裂并发症的危险因素,早期识别心脏破裂高危人群,有利于在急性心肌梗死的早期采取干预措施以减少心脏破裂的发生。创新要点：既往缺乏对中国sT段抬高型心肌梗死继发心脏破裂的系统风险评估,本研究采用回顾性队列研究的方法,完善并健全中国多中心的急性心肌梗死数据库,样本总量达到9798例,为国内同类研究中样本量最多。既往的国外文献报道：女性、高龄、心梗后就诊时间延迟、前壁心肌梗死、溶栓治疗等是心肌梗死后心脏破裂的独立危险因素。本研究在中国人群验证以上危险因素的基础上首次提出就诊时血色素下降及白细胞计数的升高与随后发生的心脏破裂密切相关。新的心脏破裂预测因素的发现有利于对心脏破裂更精细化的危险分层,早期识别心脏破裂高危人群。研究方法：建立中国多中心心肌梗死数据库,比较发生心脏破裂与未发生心脏破裂患者临床特点的差异,筛选敏感特异的心脏破裂的独立预测因素。重要结论：中国人群急性ST段抬高型心肌梗死后心脏破裂的发生率是1．82％,独立预测因素主要包括：高龄、女性、就诊时静息心率增快、前壁心肌梗死、心功能不全、就诊时间延迟、肾功能不全、贫血与白细胞计数升高。本文第一次提出就诊时贫血状态及白细胞计数的升高时与心脏破裂的发生直接相关。 相似文献
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