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壳聚糖对乳房炎奶牛血清胆固醇、尿酸和肌酐的影响 总被引：4，自引：0，他引：4
为确定壳聚糖对奶牛乳房炎的治疗效果,选择产奶量、胎次和泌乳期相近,营养中等,乳房炎阴性奶牛6头,阳性30头,组成0(阴性对照组)、1(阳性对照组)和2、3、4、5组(试验组),每组6头.各组基础日粮和饲养管理相同.分别在基础日粮中添加壳聚糖0g、0g、10g、20g、40g和80g/d/头.连续喂养2周,分别与试验的0d、7d、14d采取血样,分离血清,测定血清中胆固醇、尿酸和肌酐的含量.结果:应用壳聚糖7～14d后,2、3、4、5组奶牛血清胆固醇含量均数有随壳聚糖用量的增加而降低的趋势,但差异不显著(P﹥0.05);血清尿酸和肌酐水平显著(P﹤0.05)或极显著(P﹤0.01)地降低.结论:壳聚糖具有加快乳房炎患牛机体对尿酸和肌酐排泄的功能,提高机体对炎症的抵抗力,促进机体的康复过程. 相似文献
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Prabhat Kumar Nigam 《Indian journal of clinical biochemistry : IJCB》2016,31(2):237-239
The negative interference by bilirubin in serum creatinine estimation by Jaffe’s kinetic method is well known. Several approaches have been suggested to overcome this interference. In this article three different creatinine kits (Jaffe’s kinetic method) have been tested for bilirubin interference and its rectification using two simple approaches. The performance of three kits (A, B and C) supplied by three different manufacturers was tested using IQC and EQAS sera and pooled serum with added bilirubin. To overcome the bilirubin interference two approaches viz. NaOH preincubation and TCA precipitation were used. Bilirubin did interfere in creatinine estimation after a certain level (2.3 mg/dl). However, both NaOH preincubation and TCA precipitation approach rectified this interference. The performance of kit A was better than kit B and C. All the three kits showed bilirubin interference upon increasing the bilirubin concentration but kit A performed better than kit B and C. However, NaOH incubation and TCA precipitation methods overcame this interference to a great extent. 相似文献
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Ravjit Kaur Sabharwal Parduman Singh M. M. Arora B. L. Somani Vivek Ambade 《Indian journal of clinical biochemistry : IJCB》2008,23(1):71-75
The prevalence of microalbuminuria was assessed in 174 albustix negative hypertensive patients by estimating albumin in the
morning random urine samples by immunoturbidimetric method within four hours of voiding of urine. The urine samples were not
stored and collected without any preservatives. The urinary albumin was calculated in terms of ratio with respect to urinary
creatinine and expressed as albumin creatinine ratio (mg/g). Out of 174 albustix negative hypertensives, 58 (33.3%) patients
were found to have microalbuminuria. The prevalence of microalbuminuria in males and females was found to be 34% and 30.7%
respectively. No correlation was found between the Body Mass Index (BMI) and albumin excretion (r2 = 0.0271) and between duration of hypertension and urinary albumin excretion (r2 = 0.0042). Prevalence of microalbuminuria in nonsmokers and non-alcoholic hypertensives was 20%. The prevalence in alcoholics,
smokers and both smokers and alcoholics was found to be 35%, 42% and 41% respectively. The high prevalence of microalbuminuria
than the various reported studies on the subject demands establishment of a screening programme for microalbuminuria, implementation
of specific intervention methods and education of hypertensive patients about the consequences of smoking and alcohol on possible
involvement of renal system. 相似文献
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Fouzia Rashid M. Kaleem Sheema B. Bano 《Indian journal of clinical biochemistry : IJCB》2005,20(1):109-114
The present study is related to the comparative effects of fish oil and olive oil supplementation on gentamicin induced nephrotoxicity
in rats. Three treatment groups (Pretrement, Co-treatment and post treatment) were chosen for the study. Nephrotoxicity in
rats was induced by intraperitonial administration of gentamicin (80 mg/kg/d) for 3,5,7,10,& 12 consecutive days. The animals
were sacrificed 12 hrs after last treatment in each group. The maximum nephrotoxicity was developed on 10 days treatment of
gentamicin. For each group a control group was taken without any oil or gentamicin treatment. Beneficial effects of oils were
evidenced by reduced serum urea and creatinine concentrations in the group receiving oils compared to the non oil treatment
animals receiving gentamicin only. Further, the changed values of alkaline phosphatase and acid phosphatase activity retumed
to normal in kidney and liver tissue homogenates after fish and olive oil treatment. In this study, it was found that co-treatment
of fish and olive oil is more effective antagonist of gentamicin induced nephrotoxicity. However fish oil was found to be
more effective. Hypercholesteromia associated with gentamicin induced nephrotoxicity is also lowered by oil supplementations.
The beneficial effects of these oils are due to counteracting effect of the biochemical alterations induced by the drug. 相似文献
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Krishnamurthy N Arumugasamy K Anand U Anand CV Aruna V Venu G 《Indian journal of clinical biochemistry : IJCB》2011,26(2):120-124
Cystatin C is an emerging parameter for the assessment of renal allograft function. The objective of the study was to compare
the efficacy of serum cystatin C (SCys) with the established parameter serum creatinine (SCr) in the assessment of renal function
in renal transplant recipients (RTR). The glomerular filtration rate (GFR) of 30 renal transplant patients and 29 control
subjects was determined using 99mTc Diethylene-triamine-penta-acetate (DTPA) method. SCr was measured using an automated Jaffe’s assay and SCys was measured
using latex particle enhanced turbidimetric immuno assay (PETIA). The modification of diet in renal disease (MDRD) formula
was used to calculate GFR from SCr, while the Le Bricon formula was used to derive GFR based on SCys. Statistical analysis
was performed using MedCalc software. SCr and SCys levels were significantly higher, while DTPA clearance was significantly
lower in RTR (P < 0.0001) when compared with controls. The correlation coefficient (r value) between calculated GFR based on MDRD method and DTPA clearance was 0.343 (P = 0.06) while the calculated GFR based on Le Bricon formula was 0.694 (P < 0.001). The results have shown that SCys is a better parameter than SCr in assessing renal function in RTR. The inclusion
of SCys as an additional parameter would certainly help in detection of even a marginal decline in renal function and also
in adjusting the dosage of immunosuppressive drugs. 相似文献
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目的:研究金钱草不同部分对草酸钙结石小鼠肾脏功能及其对肾脏组织中骨桥蛋白(OPN)免疫印迹表达的影响。方法:小鼠给予含1%乙二醇和1%氯化铵的饮水,造成小鼠草酸钙结石模型,同时分别给予金钱草石油醚部分、氯仿部分、乙酸乙酯部分、正丁醇部分、水相部分提取物,试验期42天,试验结束时,测定血清中尿酸、尿素氮和肌酐的含量,采用免疫印迹法(Western blotting)测定肾组织OPN蛋白表达水平。结果:各组小鼠血清中的尿酸含量差异均不显著;结石组尿素氮含量极显著高于对照组,金钱草氯仿、乙酸乙酯、正丁醇组尿素氮含量极显著低于结石组;结石组肌酐含量极显著高于金钱草石油醚、氯仿、乙酸乙酯、正丁醇、水相组;结石组肾组织中的OPN的表达显著高于对照组,金钱草氯仿、乙酸乙酯、正丁醇、水相组的OPN的表达均显著低于结石组。结论:金钱草的氯仿、乙酸乙酯和水相组分可降低结石小鼠血清中尿素氮和肌酐的含量,增强肾脏的代谢能力,金钱草氯仿、乙酸乙酯、正丁醇、水相组均能降低肾组织中的OPN的表达,产生抑制草酸结石的效果。 相似文献
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