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G. N. Raval L. J. Parekh D. D. Patel F. P. Jha R. N. Sainger P. S. Patel 《Indian journal of clinical biochemistry : IJCB》2004,19(2):60-71
Sialic acid, the end moieties of the carbohydrate chains are biologically important and essential for functions of glycoconjugates
and are reported to be altered in cancer patients. Two hundred and twenty five breast cancer (BC) patients, 100 patients with
benign breast disease (BBD) and 100 healthy females (controls) were enrolled for the study. Eight hundred and twenty four
follow-up samples of 225 breast carcinoma patients were also evaluated. The association of sialic acid forms, sialyltransferase
and α-2–6 sialoproteins levels with presence and extent as well as prognosis of breast carcinoma was studied. Serum sialic
acid forms and sialyltransferase revealed significantly elevated levels among untreated breast cancer patients as compared
to the controls, patients with BBD as well as cancer patients in remission. Non-responders showed comparable levels of the
markers with those found in breast cancer patients at the time of diagnosis. Higher levels of sialic acid forms at diagnosis
were associated with poor prognosis. A positive correlation between serum levels of different forms of sialic acids and extent
of malignant disease was observed. The changes in serum proteins with terminal α-2–6 sialic acid correlated well with alterations
in the levels of sialic acid forms and sialyltransferase. Malignant tissues showed elevated levels of sialic acid and sialyltransferase
as compared to surrounding normal tissues.
The results suggested potential utility of these markers in evaluation of clinical outcome. 相似文献
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Kiran Hasija 《Indian journal of clinical biochemistry : IJCB》2002,17(1):12-19
Changes in erythrocyte membrane glycoproteins during, leukaemia were investigated in one hundred patients. Control group contained
normal ones. The total protein and protein bound total carbohydrates (neutral sugars) in the glycoproteins extracted from
the erythrocyte membrane showed significant reduction in total protein and protein bound total carbohydrates before radiotherapy.
However, after the radiotherapy there was further reduction in total protein by 10.41% whereas there was increase in total
carbohydrates by 9.98%. Qualitative analysis reveals that with the help of lectins one can pin point the sugars which appear
or disappear due to leukaemia. The test could be of a diagnostic value. 相似文献
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Serum glycoproteins were evaluated in oral squamous cell carcinoma patients treated with radiotherapy and also the effect
of vitamin E was studied. Cell surface glycoconjugates are important parameters in the detection of malignancy. Thus, the
objective of the present study is to evaluate the efficacy of vitamin E on glycoproteins in oral cavity cancer patients treated
with radiotherapy. The study includes 26 age and sex matched normal healthy individuals and 26 patients with squamous cell
carcinoma of oral cavity. These patients were divided into two groups, one for radiotherapy alone (at a dosage of 6000 cGy
in five fractions per week for a period of six weeks) and the other for radiotherapy plus vitamin E supplementation (at a
dosage of 400 IU / day of vitamin E) for the entire period of radiotherapy. Levels of hexose, hexosamine, fucose and sialic
acid were increased in oral squamous cell carcinoma patients and a significant decrease was observed in radiation treated
patients when compared to control. The levels of glycoconjugates were significantly decreased in radiation treated patients
supplemented with vitamin E. This measurement may be useful in assessing disease progression and identifying patients resistant
to therapy and a possible role of vitamin E on reduction in glycoconjugate levels of radiation treated oral squamous cell
carcinoma patients. 相似文献
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Mukesh Nandave S K Ojha Ranjit Kaur 《Indian journal of clinical biochemistry : IJCB》2005,20(2):154-157
The present study deals with estimation of levels of fractions of serum glycoproteins, protein bound hexose (PBH), protein
bound hexosamine (PBHex), protein bound fucose (PBF), protein bound sialic acid (PBS) and protein bound carbohydrate (PBC)
in thirty patients of Major Depressive Disorders (MDD) in comparison with thirty normal subjects. In patients of MDD, the
level of PBH, PBHex, PBF, PBS and PBC were significantly higher as compared to the normal subjects (p<0.05). In patients,
of MDD, after one-month treatment with fluoxetine, the levels of PBH, PBHex, PBF, PBS and PBC were significantly decreased
as compared to the levels of these fractions in same patients of MDD before beginning of the treatment (p<0.05). Based on
findings of the present study, it can be concluded that changes in the level of serum glycoproteins level before and after
treatment with fluoxetine can be correlated with clinical status of MDD. 相似文献
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BackgroundBiosurfactants are surface active molecules produced by microorganisms which have the ability to disrupt the plasma membrane. Biosurfactant properties are important in the food, pharmaceutical and oil industries. Lactic acid bacteria can produce cell-bound and excreted biosurfactants.ResultsThe biosurfactant-producing ability of three Lactobacillus strains was analyzed, and the effects of carbon and nitrogen sources and aeration conditions were studied. The three species of lactobacillus evaluated were able to produce biosurfactants in anaerobic conditions, which was measured as the capacity of one extract to reduce the surface tension compared to a control. The decreasing order of biosurfactant production was L. plantarum>Lactobacillus sp.>L. acidophilus. Lactose was a better carbon source than glucose, achieving a 23.8% reduction in surface tension versus 12.9% for glucose. Two complex nitrogen sources are required for growth and biosurfactant production. The maximum production was reached at 48 h under stationary conditions. However, the highest level of production occurred in the exponential phase. Biosurfactant exhibits a critical micelle concentration of 0.359 ± 0.001 g/L and a low toxicity against E. coli. Fourier transform infrared spectroscopy indicated a glycoprotein structure. Additionally, the kinetics of fermentation were modeled using a logistic model for the biomass and the product, achieving a good fit (R2 > 0.9).ConclusionsL. plantarum derived biosurfactant production was enhanced using adequate carbon and nitrogen sources, the biosurfactant is complex in structure and because of its low toxicity could be applied to enhance cell permeability in E. coli.How to cite: Montoya Vallejo C, Florez Restrepo MA, Guzmán Duque FL, et al. Production, characterization and kinetic model of biosurfactant produced by lactic acid bacteria. Electron J Biotechnol 2021;53. https://doi.org/10.1016/j.ejbt.2021.06.001 相似文献
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