Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

Digital Module 05: Diagnostic Measurement—The G‐DINA Framework https://ncme.elevate.commpartners.com     

Wenchao Ma  Jimmy de la Torre 《Educational Measurement》2019,38(2):114-115

In this ITEMS module, we introduce the generalized deterministic inputs, noisy “and” gate (G‐DINA) model, which is a general framework for specifying, estimating, and evaluating a wide variety of cognitive diagnosis models. The module contains a nontechnical introduction to diagnostic measurement, an introductory overview of the G‐DINA model, as well as common special cases, and a review of model‐data fit evaluation practices within this framework. We use the flexible GDINA R package, which is available for free within the R environment and provides a user‐friendly graphical interface in addition to the code‐driven layer. The digital module also contains videos of worked examples, solutions to data activity questions, curated resources, a glossary, and quizzes with diagnostic feedback.  相似文献   

对民国档案文件级整理工作的思索     

陈晓敏 《山西档案》2006,(1):35-37

在建国后五十多年时间里，档案工作在民国档案整理工作中，遵循档案形成的客观规律，依据全宗原则、利用原基础原则，对全国民国档案进行了案卷级整理工作，逐步建立了包括全宗目录、案卷目录、人名目录、地名目录等在内的民国档案目录体系，部分档案馆还建立了馆藏民国档案案卷级机读目录数据库。不过，随着民国档案开放力度增大，对档案内容信息的揭示提出了更高的要求，原有的民国档案整理成果已难满足现有的民国档案工作需要，对民国档案信息作进一步开发，即开展民国档案件级整理工作已逐渐被提上议事日程，但这项工作对我们来说是崭新的，我们需要对其必要性、和案卷级整理工作的衔接、应结合档案馆数字化工作开展以及在整理人员启用上如何谋求社会力量的支援等等问题加以认真思索。  相似文献   

Google应用技巧   总被引：5，自引：0，他引：5  

常春 《现代图书情报技术》2004,20(6):53-55

文章详细分析了网络搜索引擎Google 的功能特征, 讨论了在使用中存在的一些现象和问题。通过具体例证说明: 在进行组合查询时, 要对所有的查询词分别加引号; Google 在对中文繁简字体语义转换时, 有可能出现明显的错误; 搜索到的数据在同一范围内、在以小时为单位内也会出现巨大的变化; 以及在不同范围内, 搜索同一信息时, 随时间的不同, 搜索到的结果会有不同的排序。  相似文献   

COUNTER R5的新特性及对图书馆的影响     

侯景丽 《图书馆杂志》2018,(12):46-55

COUNTER是规范网络化电子资源使用统计报告数据处理、审核和提交的国际化标准,是图书馆电子资源使用量统计和评估的核心要素。目前COUNTER已经发布了最新版本R5,了解R5的新特性及与之前版本的不同对于图书馆的电子资源统计工作具有重要意义。本文拟从COUNTERR5的报告设置、报告的指标类型、数据类型、访问类型和其他完善报告的属性来解析R5,同时介绍R5对SUSHI收割的影响、"持续维护"的概念、R5发布对图书馆的影响和R5实施的重要时间节点,同时也对R5较之R4的发展和不同进行了比较和分析。COUNTERR5的主要关注点是一致性、清晰性和简单性,较之COUNTERR4有了明显的完善,同时包含了持续的维护过程,允许对代码进行更新而不必再引入一个全新的版本,解决了版本升级会对供应商和图书馆带来的各种时间和人员成本的影响。  相似文献   

Restorative Practice in New Zealand Schools: Social development through relational justice     

Wendy Drewery 《Educational Philosophy and Theory》2016,48(2):191-203

This article proposes that restorative justice practices (RJPs), as used in New Zealand schools, are better understood as an instrument of social development than a behaviour management practice. Concerns about the achievement of Māori students are relocated, from an individualised psychological and pedagogical problem to an interdisciplinary context of historical and social development. Social constructionist theory is suggested as a lens through which RJPs in schools may be seen as the intentional production of respectful social relationships, rather than as behaviour management. A restorative process has the productive capacity to restore healthy relational functioning, both for those who have been offended against and those who have offended. It is argued that the primary function of restorative justice in schools is not about resolving specific conflicts, but rather, about the production and maintenance of respectful relationship, which is the antithesis of colonised relationship. Such a position reflects accountability on a communal, rather than individualised basis, and accords with recent moves in the United Nations Development Programme to look at Human Development as building agentive capacity.  相似文献   

比较文学教学的四个关键词     

吴家荣 《安徽教育学院学报》2011,29(1):116-118

比较文学作为一门学科,内容丰富、学理性强。如何使学生真正了解比较文学学科的价值、意义,使他们正确运用比较文学原理、方法,深入开展文学研究,四个关键词至关重要,即：比较;影响;可比性;变异性。学生只有充分了解关键词的含义,切实掌握了关键词的运用,比较文学的教学才能收到事半功倍的成效。  相似文献   

清初画坛"四王"新论     

刘世军  朱晓玲 《江西教育学院学报》2003,24(5):113-116

长期以来人们对清初画派“四王”争论颇多，人们一直认为他们是复古主义者，形式主义者，只会临、摹、仿、抚四大本领，只会把古人丘壑搬来搬去组合画面。他们的出现阻碍了中国绘画的发展。本文作者将分三个专题为“四王”辩护，以见出“四王”的价值和意义。  相似文献   

社鼠、雷琼社鼠和针毛鼠染色体分类的研究   总被引：2，自引：0，他引：2  

江庆澜 《中山大学学报论丛》1995,(1)

社鼠、雷琼社鼠和针毛鼠都是山地栖息种类，它们染色体的2n数目和形态明显有别于同属的其他各种．体现出它们之间的亲缘关系较近，它们间的核型演化是通过罗伯逊易位和缺失途径，社鼠、雷琼社鼠和针毛鼠有着不同于属中其他种类的生态位，把它们另作一属会恰当些；社鼠和雷琼社鼠的地理分布有所不同．但染色体组型并不差异．认为它们间可能仅是毛色变异，而不存在两个亚种之分．  相似文献   

走出民主观念的五大误区     

杨金刚 《乌鲁木齐职业大学学报》2004,13(3):23-25,35

对民主观念的理解我们要走出以下五大误区:民主不是“为民求主”、“为民作主”,而是人民作主;民主不是多数压制少数,而是多数尊重和保护少数;民主不是否定个人,而是弘扬个人;民主不是只讲权利,而是也讲义务;民主不是追求最优的求全机制,而是保证满意的纠错机制。  相似文献