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目的探讨食管癌患者年龄、吻合位置与术后并发症发生率和死亡率的关系,以及新辅助化疗对食管癌手术切除率的影响。方法回顾性分析西安交通大学医学院第一医院肿瘤外科自1997年~2003年首诊收治、资料完整587例食管癌患者资料。结果不同年龄组手术切除率分别为91.2%、95.9%和97.7%(P>0.05);>70岁年龄组术后吻合口瘘发生率和术后死亡率均较其它组高(P<0.05)。胸膜顶部吻合口瘘发生率为16.67%,较其它位置吻合口瘘发生率明显高(颈部2.17%、弓上1.09%、弓后2.60%、弓下0),具有显著性差异(P=0.019)。III期食管癌患者行术前新辅助化疗组与未化疗组的手术切除率分别为96.92%和78.85%,具有显著差异(P<0.05),而术后吻合口瘘发生率和术后死亡率无明显差异(P=1.000)。结论术前新辅助化疗可提高食管癌手术的切除率并不增加术后并发症。年龄大并不完全是手术禁忌,高龄患者的手术应充分考虑患者的生理年龄。 相似文献
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目的:观察生姜泻心汤加减联合针灸防治恶性肿瘤化疗后呕吐反应的临床效果,为临床治疗提供新的经验。方法:选择68例恶性肿瘤化疗的患者,随机分为观察组和对照组各34例,观察组予生姜泻心汤联合针灸治疗,对照组应用昂丹司琼治疗。结果:观察组Ⅲ~Ⅳ度恶心呕吐发生率为41.18%,而对照组发生率为70.59%,两组差异有统计学意义(P0.05)。结论:生姜泻心汤联合针灸疗法可有效防治化疗后呕吐反应。 相似文献
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Yixin Hu Aili Chen Xinchang Zheng Jun Lu Hailong He Jin Yang Ya Zhang Pinpin Sui Jingyi Yang Fuhong He Yi Wang Peifang Xiao Xin Liu Yinmei Zhou Deqing Pei Cheng Cheng Raul C Ribeiro Shaoyan Hu Qian-fei Wang 《国家科学评论(英文版)》2019,6(3):469
Standard chemotherapy regimens for remission induction of pediatric acute myeloid leukemia (AML) are associated with significant morbidity and mortality. We performed a cohort study to determine the impact of reducing the intensity of remission induction chemotherapy on the outcomes of selected children with AML treated with a low-dose induction regimen plus granulocyte colony stimulating factor (G-CSF) (low-dose chemotherapy (LDC)/G-CSF). Complete response (CR) after two induction courses was attained in 87.0% (40/46) of patients receiving LDC/G-CSF. Post-remission therapy was offered to all patients, and included standard consolidation and/or stem cell transplantation. During the study period, an additional 94 consecutive children with AML treated with standard chemotherapy (SDC) for induction (80/94 (85.1%) of the patients attained CR after induction II, P = 0.953) and post-remission. In this non-randomized study, there were no significant differences in 4-year event-free (67.4 vs. 70.7%; P = 0.99) and overall (70.3 vs. 74.6%, P = 0.69) survival in the LDC/G-CSF and SDC cohorts, respectively. After the first course of induction, recovery of white blood cell (WBC) and platelet counts were significantly faster in patients receiving LDC/G-CSF than in those receiving SDC (11.5 vs. 18.5 d for WBCs (P < 0.001); 15.5 vs. 22.0 d for platelets (P < 0.001)). To examine the quality of molecular response, targeted deep sequencing was performed. Of 137 mutations detected at diagnosis in 20 children who attained hematological CR after two courses of LDC/G-CSF (n = 9) or SDC (n = 11), all of the mutations were below the reference value (variant allelic frequency <2.5%) after two courses, irrespective of the treatment group. In conclusion, children with AML receiving LDC/G-CSF appear to have similar outcomes and mutation clearance levels, but significantly lower toxicity than those receiving SDC. Thus, LDC/G-CSF should be further evaluated as an effective alternative to remission induction in pediatric AML. 相似文献
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文雪 《孝感职业技术学院学报》2021,(1):108-112
目的:研究CHOP及GRP78与复发性GBM的相关性。方法:采用Western blot检测CHOP及GRP78在初发及复发GBM组织中的表达;Real-time PCR检测GRP78在初发以及复发GBM组织中的表达。结果:CHOP及GRP78在初发GBM中表达上调,而在经过原发性肿瘤切除后接受放疗和替莫唑胺化疗的复发性GBM中增加尤为显著。结论:CHOP及GRP78在GBM发病机制中起重要作用,该分子有望成为GMB潜在的诊断及预后评估标志物。 相似文献
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王芳 《泰州职业技术学院学报》2010,10(5):42-43,68
目的探讨护理干预对肿瘤化疗患者心理问题的影响。方法应用化疗前中后期患者心理状况比较表对肿瘤化疗病人实施解释说服法,情绪转移法,暗示疗法等心理干预的前后心理状况进行评价。结果肿瘤化疗病人存在的心理问题在化疗前与化疗中比较有显著性差异（P〈0.05）。心理干预后症状明显改善,化疗前后比较（P〈0.01）。结论肿瘤化疗患者实施多层次的心理干预可清除不良心理反应,变消极心态为积极心态,配合治疗,提高生存质量。 相似文献
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Hatice Saracoglu Gulden Baskol Mevlut Baskol 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2021,31(3)
We reported macrolipasemia in a colon cancer patient during the chemotherapy period without any evidence of pancreatitis. A 52-year-old man formerly treated for papillary thyroid carcinoma had elevated a carcinoembryonic antigen (CEA) concentration in the latest control and was diagnosed with colon cancer. Xelox chemotherapy (oxaliplatin and capecitabine) protocol was planned for six months. Interestingly, the lipase activities gradually increased from 30 U/L to 434 U/L, and exceeded three times the upper limit of the reference range (13-60 U/L). There were no symptoms of pancreatitis, and the abdominal computed tomography (CT) scan was also normal. Polyethylene glycol (PEG) recovery % values of serum samples gradually decreased and were 27% in the recent sample before the end of chemotherapy. Interestingly, the serum lipase activity fell a month after chemotherapy, and PEG recovery % increased (39%). We considered the following possibilities: (1) macrolipasemia due to chemotherapy drugs, (2) macrolipasemia due to antibodies against chemotherapy drugs. 相似文献
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LuDa－yong CAOJing－yi 《上海大学学报(英文版)》2001,5(2):164-170
Sialic acids (neuraminic cids)are a special series of 9-carbon ring negatively charged carbohydrates,which has been found to be selectively changed in malignant cells from structures(both synthesis and structure modifications)to functions(up and down regulation in cells),Sialic acids,in single forms or conjugates.have been systematically studied both in lab and in clinics by GC,GCMS,NMR,HPTLC,HPLC and other modern analytical means.Sialic acids and related conjugates are predicted to be used in cancer diagnosis,cancer prognostic forecasting,designing of cancer chemotherapy regimens,uncovering carcinogenetic processes and neoplasm metastasis.Tumor cell regulative system and pathways are correlated with sialic acids,which can be applied to prognostic evaluation of cancer patients,and antimetastatic chemotherapy by sialic acid derivatives and analogues,Searching for new biological characteristics of sialic acids in cells have also been extensively studied these days.In this paper,main stream discoveries and advancements are provided.also discussions of possible mechanisms and hypotheses are invoked. 相似文献
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目的探讨FolFox4与XElox方案一线治疗晚期大肠癌的临床疗效及不良反应。方法将晚期大肠癌患者64例随机分为两组：FolFox4组采用L—OHP85mg／m2,CF200mg／m2,5-FU1000mg／m2,2周重复1次,28d为一周期;XElox组采用L—OHP130mg／m2、每2周1次,Xeloda1800mg／（m2·d）,21d为一周期。两组都化疗164周期,记录疗效与治疗期间毒副反应。结果FolFox4组总有效率56．3％（18／32）,中位缓解期7．5月,中位生存期11月;Xelox组总有效率46．9％（15／32）,中位缓解期、中位生存期分别为7．0月、9．5月。两组在客观疗效以及中位缓解期、中位生存期方面均无显著性差异。结论FolFox4与XElox方案一线疗效晚期大肠癌客观疗效中位缓解期及中位生存期比较无显著性差异,两组毒副反应均较轻,作为一线治疗晚期大肠癌两方案均可作为首选方案, 相似文献
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