Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

人体上下肢长预测方法的研究与应用     

田文秀 《山东体育学院学报》2004,20(3):60-61

人体生长发育过程中，具有非等比性和向心律的特点，在生长发育结束以前测评出的形态比例关系，不能直接说明成熟后的情况。通过对7～18岁儿童少年发育状况的调研，提出了人体上下肢长与身高比例关系的预测方法。  相似文献   

音乐对有氧耐力素质影响的研究   总被引：1，自引：0，他引：1  

洪显君 《成都体育学院学报》2002,28(2):95-96

有氧耐力是指运动员在供氧充足的情况下克服疲劳的能力，其训练目的在于增强有机体氧气运输系统的机能。将音乐引入有氧耐力训练，用呼吸频率变化等生理指标，对实验组和对照组在其提高幅度上进行实验分析，证明音乐有助于有氧耐力的提高。  相似文献   

改良小梁切除与传统小梁切除的疗效观察研究     

陈世会  黄胜 《铜仁职业技术学院学报》2006,(4)

目的:评价小梁切除术中改良巩膜瓣、睫状突定量小梁切除、不同缝合方式在术中术后的优缺点及远期疗效。方法120例(156眼)原发性青光眼随机分为4组:A组(传统术式组)30例(42眼);B组(可拆褥式缝线组)30例(40眼);C组(L形巩膜瓣小梁切除组)30例(34眼);D组(小切口睫状突定量小梁切除术组)3 0例(40眼),B.C.D组为改良术式组。比较4组术后浅前房、眼压和滤过泡情况。结果:浅前房发生率:A组26.119%(11/42),B组7.50%(3/40),C组2.94%(1/34),D组2.50%(1/40),改良术式组与传统术式组比较差异有板有统计学意义(P<0.01);随诊眼压:A组(14.65±4.30)mmHg,B组(1 3.87±3.60)m mHg,C组(15.58±3.20)mmHg,D组(14.50±3.15)mmHg,4组间差异无统计学意义(P>0.05);随诊功能性滤过泡A组76.19%(32/42),B组92.50%(37/40),C组97.05%(33/34),D组95.00%(38/40),传统小梁切除组与改良小梁切除组比较差异有统计学意义(P<0.05)。结论采用巩膜瓣可拆褥式缝合、L形巩膜瓣小梁切除、小切口睫状突定量小梁切除可大大降低术后浅前房的发生率,并能理想地控制眼压,提高术后视功能。  相似文献   

"优秀生心理综合症"及运动处方   总被引：1，自引：1，他引：0  

何新宏  安平 《体育成人教育学刊》2004,20(4):87-88

成绩优秀的学生往往存在一些特殊的心理问题，预防和消除优秀生的心理问题具有十分重要的意义。在进行体育教学和身体锻炼的同时，适当地运用运动处方，可以治疗优秀学生的心理疾病和消除心理障碍，促进优秀学生健康成长。  相似文献   

运动对呼吸链抗氧化能力的影响   总被引：1，自引：1，他引：0  

龚煦琳 《辽宁体育科技》2005,27(2):38-39

呼吸链是防御氧攻击的一道重要屏障，还原型CoQ10细胞色素c是呼吸链中抗氧化的重要物质；运动对呼吸链的抗氧化能力有重要影响。复合物Ⅰ活性与运动量、强度和时间密切相关；急性力竭运动可以使细胞色素c活性降低；辅酶Q的含量与自由基的产生呈线性相关。  相似文献   

Physical activity and nutrition guidelines to help with the fight against COVID-19     

Kayvan Khoramipour  Aref Basereh  Amirhoseein Ahmadi Hekmatikar  Lindy Castell  Ruheea Taskin Ruhee 《Journal of sports sciences》2021,39(1):101-107

ABSTRACT

As the world is witnessing the epidemic of coronavirus disease 2019, emerging genetics and clinical pieces of evidence suggest a similar immunopathology to those of severe acute respiratory syndrome and Middle East respiratory syndrome. Staying at home to prevent the spread of the virus and consequently being largely inactive is associated with unintended consequences. These can actually enhance the infection risk and exacerbate poor health conditions including impaired immune function. Physical activity is a feasible way of improving health, particularly physical and mental health in a time of social isolation. However, people with certain health conditions in these circumstances may need a special physical activity programme in addition to any exercise they may already be performing via online programmes. This review aims to provide practical guidelines during the COVID-19 quarantine period. We suggest performing aerobic, resistance training, respiratory muscle training and yoga in the healthy, and in those with upper respiratory tract illness, patients with lower respiratory tract illness should be restricted to respiratory muscle training and yoga. In addition, vitamins D and C, omega-3 fatty acids, and regular consumption of fruit and vegetables might be considered as nutritional aids to support the immune system in those affected by COVID-19.  相似文献   

Compensatory changes in physical activity and sedentary time in children and adolescents with cystic fibrosis     

Kelly A. Mackintosh  Nicola D. Ridgers  Melitta A. McNarry 《Journal of sports sciences》2019,37(13):1506-1511

Physical activity (PA) is a key element in Cystic Fibrosis (CF) treatment strategies, yet little is known as to whether activity compensation occurs. This study examined whether PA and/or sedentary time on one day were temporally associated with time spent in these intensities the following day in youth with CF. Time spent sedentary and in different PA intensities were objectively-measured for seven consecutive days in 50 youth (22 boys; 12.0 ± 2.7 years); 25 with mild-to-moderate CF and 25 age- and sex-matched controls. Multilevel analyses (day and child) were conducted using generalised linear latent and mixed models. On any given day, every additional 10 minutes spent in sedentary time or moderate-to-vigorous physical activity (MVPA) were associated with 1.9 (95%CI: ?3.6 to ?1.2) and 12.4 (95%CI: ?22.1 to ?2.9) minutes less sedentary time the following day, respectively. These temporal associations were also observed when split by group (3.1 vs. 1.9 minutes for healthy and CF, respectively). These findings indicate that youth do not compensate their PA, irrespective of disease status, between days, but may compensate their sedentary time between days. Experimental studies are warranted to fully elucidate whether compensatory responses to PA and sedentary time occur, which is fundamental for informing PA promotion strategies.  相似文献   

单向S-粗模糊集     

邱锦明  余文琼  刘墨德 《三明学院学报》2006,23(2):124-128

结合模糊集理论和单向S-粗集理论,基于动态系统提出了单向S-粗模糊集的概念、结构及其性质,对此进行了讨论并给出应用实例。  相似文献   

论英译汉中的常见错误与对策     

陈冬秀 《柳州师专学报》2004,19(4):51-55

分析了英译汉过程中的常见错误或问题(翻译综合症)，同时指出产生这些错误的原因，并在此基础上提出了解决问题的对策。  相似文献