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The polyadenylation code: a unified model for the regulation of mRNA alternative polyadenylation 总被引：3，自引：2，他引：1
The majority of eukaryotic genes produce multiple mRNA isoforms with distinct 3′ ends through a process called mRNA alternative polyadenylation (APA). Recent studies have demonstrated that APA is dynamically regulated during development and in response to environmental stimuli. A number of mechanisms have been described for APA regulation. In this review, we attempt to integrate all the known mechanisms into a unified model. This model not only explains most of previous results, but also provides testable predictions that will improve our understanding of the mechanistic details of APA regulation. Finally, we briefly discuss the known and putative functions of APA regulation. 相似文献
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知识工作背景下,传统以控制为导向的绩效评价系统明显不适应当前快速反应和工作自主要求的组织策略。而现有研究拘泥于结构化设计,缺乏对不同情境下绩效评价有效性的探讨。本文借鉴传统机制设计理论,在满足员工参与约束、激励相容约束的基础上引入承诺约束,构建了一个权变而动态的激励－绩效模型,并据此分离出三种情境下的最优绩效评价系统模式。本文证明,社会控制及自我约束与绩效控制之间存在反向替代关系,在企业与知识员工之间建立关系型心理契约,通过愿景引导、文化熏陶、自我主导等手段,能够深度挖掘员工创造力、组织凝聚力、团队协同力等隐性价值驱动因素,促进企业在更高层面上创造价值。 相似文献
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James Heather 《Assessment & Evaluation in Higher Education》2010,35(6):647-660
In recent times, plagiarism detection software has become popular in universities and colleges, in an attempt to stem the tide of plagiarised student coursework. Such software attempts to detect any copied material and identify its source. The most popular such software is Turnitin, a commercial system used by thousands of institutions in more than 100 countries. Here, we show how to fix a loophole in Turnitin's current plagiarism detection process. We demonstrate that, in its current incarnation, one can easily create a document that passes the plagiarism check regardless of how much copied material it contains; we then show how to improve the system to avoid such attacks. 相似文献
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针对小灵通这种基于“落后”技术的产品，分析了其商业化价值。小灵通拥有强大的商业化能力，显著地提升了我国两大语音通信市场特别是移动电话市场的价值，其对消费者福利的年均贡献达到近百亿元。鉴于我国居民的实际收入水平增速较慢，小灵通的绿色环保特征及其与固定电话的捆绑关系，预期小灵通还会有更长的生命周期。 相似文献
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