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Objective: The aim of this paper is to compare the propofol concentration in plasma and cerebrospinal fluid (CSF) in patients
scheduled for intracranial tumor removal and anaesthetized using propofol as part of a total intravenous anaesthesia technique.
Methods: Twenty-seven patients (ASA I–II) scheduled for elective intracranial tumor removal were studied. Anesthesia was induced
with 2 mg/kg propofol for 5 min and infused at 10 mg/(kg·h) for 5 min and then stopped. CSF and arterial blood were collected
simultaneously before infusion of propofol and at different time points after infusion of propofol according to bispectral
index (BIS) values. Concentrations of propofol in plasma and CSF were measured by HPLC with fluorescence detection. The correlation
coefficient and regression equation between plasma and CSF concentration of propofol were worked out by linear simple regression.
Results: The propofol CSF concentration that we measured was 1.46% of the plasma concentration. The coefficient of relation
between plasma and CSF concentration was 76.7%. Conclusions: The propofol CSF concentration was positively correlated with
and much lower than the plasma concentration. Discrepancies may result from high plasma protein binding of propofol, intracranial
pathology and sampling volume.
Project supported by Startup Foundation for Introducing Talent of Zhejiang University, China 相似文献
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PubMed中麻醉学研究文献计量学分析 总被引：3，自引：0，他引：3
目的:对麻醉学研究文献进行计量分析,以确定其文献增长规律和发展趋势,为研究麻醉学相关课题提供依据。方法:登录www.ncbi.nlm.nih.gov/Pubmed(PubMed数据库)后用"anaesthesia(麻醉学)"检索"从1866/01/01到2009/12/31"文献量(每5年),例如:Search(″1866/01/01″[Publication Date]:″2009/12/31″[Publication Date])AND(anaesthesia),数据库中文献的语言分布和神经神经科学主要杂志刊载的文献量,并在此基础上分别检索各时间段,即:≤1900/12/31,1901/01/01-1905/12/31,1906/01/01-1910/21/31,……2001/01/01-2005/12/31,2006/01/01-2009/12/31各时段文献量,以及1956年以来中文麻醉学每5年文献量。根据科学文献增长规律的理论,对所得数据进行分析。结果:截止2009年底累计收录麻醉学文献281 326篇。根据PubMed数据库文献类型,包括Review(21 710篇),RandomizedControlled Trial(22 528篇),Practice Guideline(339篇),Meta-Analysis(439篇),Letter(21 635篇),Editorial(3 429篇),ClinicalTrial(31 581篇),Others(180 665篇)。PubMed中收录麻醉学文献分为PubMed Central(10 170篇),MEDLINE(269 162篇)和其他(1 994篇);根据Journal Groups分为Nursingjournals 4 258篇,Dental journals 10 974篇,Core clinical journals 63 371篇,其他202 723篇;与Humans相关文献191 900篇,Animals相关文献63 371篇,其他202 723篇。1966-2005年40年中文献量增多近似直线(y=5180.5x+3685.8,R2=0.9458)。PubMed收录中文麻醉学文献从1956年开始,1986年后明显上升,但其方程接近幂指数(y=4.0874e0.4279x,R2=0.7497)。麻醉学文献以英语为主(221 727/281 326,78.81%),中文发表的文献量排在第9位(2 309/281 327,0.82%)。PubMed中24种麻醉学相关期刊(SCI收录期刊)收录文献95 155篇(32.66%)。结论:PubMed中麻醉学研究文献以英文为主,文献量逐年缓慢递增,1966年以来文献量增加近似直线(y=5180.5x+3685.8),说明麻醉学研究在最近半个世纪以来一直处于较为热门阶段。 相似文献
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目的观察咪达唑仑预防腰-硬联合麻醉下妇科手术后恶心呕吐的效果。方法腰-硬联合麻醉妇科手术患者90例,随机分为M（咪达唑仑）组、G（格拉斯琼）组和NS组,手术结束时分别静注咪迭唑仑2mg,格拉斯琼3rag和生理盐水3ml,10min后开始硬膜外自控镇痛（PCEA）,观察病人术后24h内恶心呕吐和镇静情况。结果NS组患者恶心呕吐总发生率（56．7％）显著高于其他两组（P〈0．01）,M组（32．3％）和G组（24．1％）差异无统计学意义（P〉0．05）。术后2h时M组镇静程度高于C组和NS组（P〈0．05）,但Ramsay评分均未超过3分;4h时3组病人镇静程度相近。结论腰-硬联合麻醉下行妇科手术的病人手术结束时静脉注射咪达唑仑2mg可以有效预防术后恶心呕吐,其效果和格拉斯琼3mg相似,且未表现出明显的镇静作用。 相似文献
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INTRODUCTION The specific morphologic properties of choroidal epithelium and the existence of a cerebrospinal fluid(CSF)pathway for drug distribution to the central nervous system(CNS)suggest that the choroid plexus-CSF route may be more significant than pre-viously thought for drug delivery to the brain(Ghersi-Egea and Strazielle,2001).There is limitedl d l d-n d information about the CSF pharmacokinetics of propofol in humans(Engdahl et al.,1998;Dawid-owicz et al.,2001a).Propofol… 相似文献
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