Role of Cytokines in the Pathogenesis of Non-Alcoholic Fatty Liver Disease |
| |
| Authors: | Subir Kumar Das V Balakrishnan |
| |
| Institution: | (1) Department of Biochemistry, College of Medicine and JNM Hospital, WBUHS, Kalyani, Nadia, India;(2) Department of Gastroenterology, Amrita Institute of Medical Sciences, Ponekkara P.O., Cochin, 682 041, Kerala, India |
| |
| Abstract: | A number of factors are linked with non-alcoholic fatty liver diseases (NAFLD), a condition that ranges from clinically benign
fatty liver to its more severe form, non alcoholic steatohepatitis (NASH). In this study, we evaluated the role of cytokines
secreted from adipose tissue in the pathogenesis and progression of NAFLD. We also compared anthropometric profile, lipid
profile and insulin resistance data in 105 NAFLD patients with 77 normal subjects. These subjects showed a normal serum albumin
level, prothrombin time and renal function but elevated aminotransferases. Predisposing factors were diabetes mellitus (35%),
overweight (56%) and hyperlipidemia (44%). Insulin resistance (IR), determined by homeostasis model assessment (HOMA) was
confirmed in 70% patients with NAFLD and 42% patients fulfilled the minimum criteria for insulin resistance syndrome (IRS).
NAFLD patients showed elevated levels of pro-inflammatory cytokines tumor necrosis factor (TNF)-α, and interleukin (IL)-6,
while anti-inflammatory cytokines IL-4 level decreased and IL-10 level remain unchanged; however, TGF-β1 level elevated significantly
compared to normal subjects. While insulin level and HOMA-IR both were significantly positively correlated with BMI, waist-to-hip
ratio, total cholesterol, VLDL-cholesterol, triglyceride and TGF-β1; glucose, IL-6 and TNF-α levels were significantly positively
correlated with HOMA-IR only. In conclusion, pro-inflammatory cytokines play an important link between metabolic and liver
disorders in the fat accumulation, and thereby cause IR, inflammation and liver fibrosis. |
| |
| Keywords: | Insulin resistance Interleukin-6 Non-alcoholic fatty liver disease Transforming growth factor beta Tumor necrosis factor-alpha |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
