Anti-allergic effects of ethanol extracts from brown seaweeds |
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| Authors: | Haider Samee Zhen-xing Li Hong Lin Jamil Khalid Yong-chao Guo |
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| Institution: | (1) Food Safety Laboratory, College of Food Science and Engineering, Ocean University of China, Qingdao, 266003, China;(2) Food and Marine Resources Research Centre, Pakistan Council of Scientific and Industrial Research (PCSIR) Laboratories Complex, Karachi, 75280, Pakistan |
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| Abstract: | Ethanol extracts of brown seaweeds from Pakistan and China were isolated and compared for their antiallergenic activities.
They included Sargassum tennerimum (ST) and Sargassum cervicorne (SC) from Pakistan, and Sargassum graminifolium turn (SG), Sargassum thunbergii (STH), and Laminaria japonica (LJ) from China. The ethanol extracts of these brown seaweeds were optimized at 85% (v/v) ethanol for the maximum yield of
phlorotannin, an inhibitor against hyaluronidase. Total phlorotannins contained in the crude extracts were measured as 1.71%
(SG), 0.74% (STH), 0.97% (LJ), 3.30% (SC), and 5.06% (ST). The 50% inhibitory concentrations (IC50) of Pakistani SC and ST
were 109.5 and 21 μg/ml, respectively, lower than those of Chinese SG, STH, and LJ (134, 269, and 148 μg/ml, respectively).
An antiallergic drug, disodium cromoglycate (DSCG), had an IC50=39 μg/ml, and a natural inhibitor of hyaluronidase, catechin, had an IC50=20 μg/ml. The IC50 of ST extract was found similar to that of catechin (21 vs 20 μg/ml) and lower than that of DSCG (21 vs 39 μg/ml). This suggests
that ST is a potent inhibitor of hyaluronidase, indicating a promising future development of natural antiallergic medicines
or functional foods.
Project supported by the Hi-Tech Research and Development Program (863) of China (No. 2006AA09Z427), and the National Natural
Science Foundation of China (Nos. 30800859 and 30871948) |
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| Keywords: | Anti-allergic activity Brown seaweed Ethanol extracts Hyaluronidase Phlorotannin |
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