From Genes to Environment: Using Integrative Genomics to Build a “Systems‐Level” Understanding of Autism Spectrum Disorders |
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| Authors: | Valerie W Hu |
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| Institution: | The George Washington University, School of Medicine and Health Sciences |
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| Abstract: | Autism spectrum disorders (ASD) are pervasive neurodevelopmental disorders that affect an estimated 1 in 110 individuals. Although there is a strong genetic component associated with these disorders, this review focuses on the multifactorial nature of ASD and how different genome‐wide (genomic) approaches contribute to our understanding of autism. Emphasis is placed on the need to study defined ASD phenotypes as well as to integrate large‐scale “omics” data in order to develop a “systems‐level” perspective of ASD, which in turn is necessary to allow predictions regarding responses to specific perturbations and interventions. |
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