| 反丁烯二酸单苄酯的合成及抑菌活性研究 |
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| 引用本文： | 陈素艳,欧光南,周常义.反丁烯二酸单苄酯的合成及抑菌活性研究[J].闽江学院学报,2010,31(2):115-119. |
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| 作者姓名： | 陈素艳 欧光南 周常义 |
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| 作者单位： | 1. 集美大学生物工程学院,福建,厦门,361005;厦门大学化学与化学工程学院,福建,厦门,361001
2. 集美大学生物工程学院,福建,厦门,361005 |
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| 基金项目： | 福建省自然科学基金计划资助项目(2006J0262);;厦门市科技项目(3502Z20073027) |
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| 摘 要： | 以顺丁烯二酸酐和苯甲醇为原料，经过单酯化和异构化两步得到反丁烯二酸单苄酯，并考察异构温度、异构时间、异构剂用量对产率的影响．结果表明反丁烯二酸单苄酯最佳工艺条件为：顺丁烯二酸酐：苯甲醇为1．1：1（摩尔比）、反应温度为90℃、时间为20min、异构温度为90℃、异构时间为2h、异构剂无水三氯化铝为0．7g（顺丁烯二酸酐9．2wt％），产率为65．5％．FT／IR和NMR袁征结果表明，反丁烯二酸单苄酯的结构与理论预测一致；生物学活性实验证实该化合物对细菌、真菌具有显著的抑菌杀菌作用，有望开发成为新型抑菌剂．
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| 关 键 词： | 反丁烯二酸单苄酯 合成 押茵活性 |
Synthesis and antimicrobial activity of mono-benzyl fumarate |
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| CHEN Su-yan,OU Guang-nan,ZHOU Chang-yi.Synthesis and antimicrobial activity of mono-benzyl fumarate[J].Journal of Minjiang University,2010,31(2):115-119. |
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| Authors: | CHEN Su-yan OU Guang-nan ZHOU Chang-yi |
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| Institution: | 1.Department of Biological Engineering;Jimei University;Xiamen;Fujian 361021;China;2.Department of Chemistry and Chemical Engineering;Xiamen University;Fujian 361005;China |
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| Abstract: | The mono-benzyl fumarate was synthesized by two-step： esterification and isomerization. The results showed that the optimum conditions for mono-benzyl fumarate were ： molar ratio of maleic anhydride to benzyl alcohol 1.1： 1, reaction temperature 90 ℃, reaction time 20 minutes and then isomerized in the presence of 0.7 g aluminum chloride anhydrous for 2 h at 90 ℃ with the yield of 65.5%. FT/IR and NMR showed that all the characterization data were consistent with the expected compositions and structures. Antimicrobial activity against bacteria, fungus were studied,The result showed that mono-benzyl fumarate had strong antibacterial activity and could be used as antimicrobial sterilization. |
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| Keywords: | mono-benzyl fumarate synthesis antimicrobial activity |
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