| 补充抗氧化剂对老年运动小鼠骨骼肌抗氧化水平的影响 |
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| 引用本文： | 卢健,陈彩珍,许永刚,赖荣兴.补充抗氧化剂对老年运动小鼠骨骼肌抗氧化水平的影响[J].体育学刊,2003,10(4):57-59. |
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| 作者姓名： | 卢健 陈彩珍 许永刚 赖荣兴 |
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| 作者单位： | 广州体育学院,科研所,广东,广州,510075 |
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| 基金项目： | 国家体育总局局管课题(编号:97060)，广东省高等学校基础研究课题(编号:9746) |
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| 摘 要： | 为了解抗氧化剂(维生素E、维生素C和硒)对老年运动小鼠抗氧化能力的影响，给老年运动小鼠补充抗氧化剂(每5mL饮用水中含VitE0．25IU，VitC 0．5mg、亚硒酸钠0．005mg)5个月，测定小鼠骨骼肌线粒体及胞浆抗氧化酶活性。结果表明，补充抗氧化剂后运动小鼠骨骼肌CuZnSOD及NnSOD活性下降。胞浆GSH-px活性明显升高，而线粒体GSH-px及胞浆Cat活性无显性变化，补充抗氧化剂的小鼠骨骼肌线粒体脂褐素含量明显降低。抗氧化剂可适度减轻运动鼠的氧化应激水平。
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| 关 键 词： | 抗氧化剂 运动小鼠 抗氧化酶 骨骼肌 |
| 文章编号： | 1006-7116(2003)04-0058-03 |
| 修稿时间： | 2002年12月5日 |
Effect of antioxidant on lipid peroxidation in skeletal muscle of exercise training aged mice |
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| LU Jian,CHEN Cai-zhen,XU Yong-gang,LAI Rong-xing.Effect of antioxidant on lipid peroxidation in skeletal muscle of exercise training aged mice[J].Journal of Physical Education,2003,10(4):57-59. |
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| Authors: | LU Jian CHEN Cai-zhen XU Yong-gang LAI Rong-xing |
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| Abstract: | To investigate the effect of antioxidant (Vitamin E, Vitamin C and Selenium) on the antioxidant ability of exercise training aged mice, the present experiment detected antioxidant enzymes activities in mitochondria and cytrol of skeletal muscle after antioxidant supplementation for 5 months. The results showed that compared with control group, CuZnSOD and Mn-SOD activities in mitochondria decreased, GSH - px in cytrol increased ,while GSH - px in mitochondria and Catalase in cytrol were no significant changes, and the level of Lipofuscin in mitochondria decreased significantly. The results suggested that the oxidant and antioxidant system were in a status of a dynamic equilibrium after antioxidant supplementation. |
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| Keywords: | antioxidant exercise mice antioxidant enzyme sketelal muscle |
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