Effect of cigarette smoking on serum lipid,lipoprotein and apolipoprotein levels in hypertensives receiving β-adrenoreceptor blocking drugs |
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| Authors: | Ananthakrishnan Ramani Sudhakar S Nayak A R Aroor G N Kundaje |
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| Institution: | 1. Department of Medicine, Kasturba Medical College, 129, K.M.C. Quarters, 576 119, Manipal, Karnataka, India
2. Clinical Biochemistry, Kasturba Medical College, 576 119, Manipal, Karnataka
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| Abstract: | Both cigarette smoking and propranolol administration significantly alter plasma lipid profile. We examined the relationship
of cigarette smoking and propranolol administration with fasting serum total cholesterol, triglyceride, lipoprotein cholesterol
subfractions (high density, low density, and very low density), Apo-A, Apo-B and ratios obtained from these variables in 42
hypertensive patients. Significantly lower values of HDL cholesterol, Apo-A and HDL-C/total cholesterol and Apo-A/Apo-B ratios
were observed in smokers taking propranolol than non-smokers not taking propranolol. Smokers who were not on propranolol also
had significantly lower values as compared to non-smokers. These findings suggest that smoking may be the more significant
factor responsible for alteration in lipid profile. |
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