| 胆管癌中p27Kip1、VEGF的表达、意义及相互关系 |
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| 引用本文： | 吴兴茂,廖玉巍,张铭琏.胆管癌中p27Kip1、VEGF的表达、意义及相互关系[J].河北北方学院学报(医学版),2003,20(2):6-8. |
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| 作者姓名： | 吴兴茂 廖玉巍 张铭琏 |
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| 作者单位： | 1. 中国医科大学第二临床学院普外科,110004
2. 沈阳民航医院,110043 |
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| 摘 要： | 目的 :探讨 p2 7Kip1、VEGF在胆管癌中的表达及相互关系。 方法 :采用免疫组化技术检测 32例胆管癌标本中p2 7Kip1及VEGF的表达。结果 :p2 7Kip1、VEGF在胆管癌和正常胆管组织中的阳性表达率分别为 5 6 .2 5 %和 11.1% (P <0 .0 1) ;81.2 5 %和 33.3% (P <0 .0 1)。p2 7Kip1、VEGF在胆管癌中的表达具有相关性 (P <0 .0 5 ) ,与分化程度、转移水平有关 ,与大小、生存期无关。结论 :p2 7Kip1、VEGF在胆管癌中高表达 ,p2 7Kip1、VEGF与胆管癌的发生、发展有关。
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| 关 键 词： | 胆管癌 p27Kip1 VEGF 免疫组织化学 |
| 文章编号： | 1005-8796(2003)-02-06-03 |
Study on the expression and the relationship between p27Kip1(Kinase inhibitor protei n1) and VEGF(Vascular Endothelial Growth Factor) in human cholangiocarcinoma |
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| Wu Xingmao,Liao Yuwei,Zhang Minglian,et al..Study on the expression and the relationship between p27Kip1(Kinase inhibitor protei n1) and VEGF(Vascular Endothelial Growth Factor) in human cholangiocarcinoma[J].Journal of Hebei North University:Medical Edition,2003,20(2):6-8. |
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| Authors: | Wu Xingmao Liao Yuwei Zhang Minglian |
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| Institution: | Wu Xingmao,Liao Yuwei,Zhang Minglian,et al. Department of Surgeory,The No.2 Clinical Hospital of China Medical University. |
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| Abstract: | Objective : To study on the expression and the relationship between p27Kip1 and VEGF in human cholangiocarcinoma by immunohistochemical staining . Methods: The expression of p27Kip1 and VEGF was detected in 32 cases of cholangiocarcinoma by immunochemical technique. Results: The positive expression rate of p27Kip1 and VEGF in human cholangiocarcinoma and normal tissues was 56.25% and 11.1% (P<0.01);81.25% and 33.3%(P<0.01),respectively.The expression of p27Kip1 and VEGF in human cholangiocarcinoma was relative and has relationship with the differential types and transplantation,but no relationship with survival period and size.Conclusion:The expression of p27Kip1 and VEGF has the relationship with the occurence and development of human cholangiocarcinoma. |
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| Keywords: | Cholangiocarcinoma p27Kip1 VEGF Immunohistochemistry |
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