| 低氧诱导因子与乳腺癌转移 |
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| 作者姓名： | Zhao-ji LIU Gregg L.SEMENZA Hua-feng ZHANG |
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| 作者单位： | CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Biology,School of Life Sciences, University of Science and Technology of China;Johns Hopkins University School of Medicine,Baltimore, MD 21205, USA |
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| 基金项目： | Project supported partially by the National Basic Research Program (973) of China，the Na-tional Natural Science Foundation of China，the Research Fund for the Doctoral Program of Higher Education of China，the Fundamental Research Funds for the Central Universities in China;and the‘1000 Youth Talent Program’ by the Chinese Government for Hua-feng ZHANG |
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| 摘 要： | 概肿瘤，特别是实体瘤，其内部微环境处于一种低氧或缺氧的状态，肿瘤的这种低氧微环境将诱导活化低氧诱导因子（HIF-1）信号通路。HIF-1信号通路在乳腺癌的转移中发挥着重要的作用。乳腺癌的转移涉及肿瘤细胞的浸润、进入血管、通过血液循环迁移、到达远端毛细血管内壁、穿透血管壁进入新的器官以及在新的部位形成转移灶等步骤，过程非常复杂。本文重点围绕 HIF-1在转移各个步骤中的作用进行综述。
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| 关 键 词： | 乳腺癌 低氧诱导因子 肿瘤转移 |
Hypoxia-inducible factor 1 and breast cancer metastasis |
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| Zhao-ji LIU,Gregg L.SEMENZA,Hua-feng ZHANG.Hypoxia-inducible factor 1 and breast cancer metastasis[J].Journal of Zhejiang University Science,2015(1):32-43. |
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| Authors: | Zhao-ji LIU Gregg L SEMENZA Hua-feng ZHANG |
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| Institution: | 1. CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Biology, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China
2. Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA |
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| Abstract: | |
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| Keywords: | Breast cancer Hypoxia-inducible factor 1 (HIF-1) Metastasis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
