Paraoxonase activity and antibodies to oxidized-LDL in chronic renal failure patients on renal replacement therapy |
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| Authors: | P R Krishnaswamy Anjali Rao W Murali H Sudarshan Ballal |
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| Institution: | (1) Department of Biochemisitry, Kasturba Medical College, Manipal, Kamataka;(2) Manipal Hospital, No. 98, Rustom bagh, Airport Road, 560 003 Banglore, Karanata |
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| Abstract: | Serum paraoxonase (PON1) and antibodies to oxidized-LDL (anti ox-LDL) were measured in chronic renal failure subjects on renal
replacement therapy such as hemodialysis (HD) peritoneal dialysis (PD) and transplantation (Txp). Paraoxonase activity was
significantly lower in HD and PD group (P<0.001) than in control subjects. In transplant patients, paraoxonase activity was
not significantly different from that of controls. Antibodies to ox-LDL was significantly higher in HD, PD and Transplant
patients (P<0.0001) compared to control subjects. High titers of antibodies were observed in the HD group compared to the
PD and Transplant subjects. A decrease in paraoxonase activity and high titers of Antibodies to ox-LDL in the dialysis group
suggest a decreased cardio protective effect of HDL and enhanced risk of premature cardiovascular complications. Whereas in
case of transplant subjects, there seems to be restoration of PON1 activity, but elevated levels of anti-oxLDL could still
be a potential atherogenic factor. Hence, we propose that estimation of these two parameters can be used as a useful index
to measure the cardiac risk in the above patient category |
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| Keywords: | Atherosclerosis HDL-cholesterol dialysis oxidative stress transplantation |
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